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Epigenetic Reader Domain

Epigenetic Reader Domain

货号 产品名 CAS号 信息
CSN28467 VZ185 2306193-61-1 VZ185 is a potent, fast, and selective VHL based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively.
CSN26644 PROTAC BRD4-binding moiety 1 2101200-10-4 PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1].
CSN22252 KG-501 18228-17-6 KG-501 is histochemical substrate of alkaline phosphatases and can inhibit CREB-CBP interaction.
CSN28535 HJB97 2093391-24-1 HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).
CSN26642 GSK9311 HCl 2253733-09-2 GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].
CSN22423 GSK1379725A 1802251-00-8 GSK1379725A is an inhibitor of Brd4 and a selective BPTF ligand (Kd=2.8 μM).
CSN20806 CeMMEC1 440662-09-9 CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 with Kd of 1.8 µM and IC50 of 0.9 µM.
CSN27738 CBP/EP300-IN-1 2443789-32-8 CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
CSN21392 AT6 2098836-50-9 AT6 is a PROTAC targeting on Brd4.
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