Epigenetic Reader Domain

Epigenetic Reader Domain
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货号	产品名	CAS号	信息
CSN26644	PROTAC BRD4-binding moiety 1	2101200-10-4	PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1].
CSN22252	KG-501	18228-17-6	KG-501 is histochemical substrate of alkaline phosphatases and can inhibit CREB-CBP interaction.
CSN28535	HJB97	2093391-24-1	HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).
CSN26642	GSK9311 HCl	2253733-09-2	GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].
CSN22423	GSK1379725A	1802251-00-8	GSK1379725A is an inhibitor of Brd4 and a selective BPTF ligand (Kd=2.8 μM).
CSN20806	CeMMEC1	440662-09-9	CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 with Kd of 1.8 µM and IC50 of 0.9 µM.
CSN27738	CBP/EP300-IN-1	2443789-32-8	CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.