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Epigenetic Reader Domain
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN28467 | VZ185 | 2306193-61-1 | VZ185 is a potent, fast, and selective VHL based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively. |
| CSN26644 | PROTAC BRD4-binding moiety 1 | 2101200-10-4 | PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1]. |
| CSN22252 | KG-501 | 18228-17-6 | KG-501 is histochemical substrate of alkaline phosphatases and can inhibit CREB-CBP interaction. |
| CSN28535 | HJB97 | 2093391-24-1 | HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively). |
| CSN26642 | GSK9311 HCl | 2253733-09-2 | GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1]. |
| CSN22423 | GSK1379725A | 1802251-00-8 | GSK1379725A is an inhibitor of Brd4 and a selective BPTF ligand (Kd=2.8 μM). |
| CSN20806 | CeMMEC1 | 440662-09-9 | CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 with Kd of 1.8 µM and IC50 of 0.9 µM. |
| CSN27738 | CBP/EP300-IN-1 | 2443789-32-8 | CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor. |
| CSN21392 | AT6 | 2098836-50-9 | AT6 is a PROTAC targeting on Brd4. |
