ErbB

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Pathway
ADC ADC Linker ADC Linker with Payload ADC Toxin
Anti-infection Antibacterial Antifungal Antiparasitic Antiviral CCR CMV Dengue Virus Filovirus HBV HCV HHV HIV HIV Integrase HIV Protease HRV HSV Influenza Virus LpxC Neuraminidase NNRTI NRTI NS2B-NS3 Protease Orthopoxvirus Prion Reverse Transcriptase RSV SARS-CoV SQLE β-lactamase FCoV 3CLpro M2 proton channel Antiprotozoal Viral MTase PLP GraR
Apoptosis Apoptosis Inducer Bcl-2 Caspase c-Myc c-RET DAPK IAP MDM2 p53 PD-1/PD-L1 PERK PKD Survivin Thymidylate Synthase TNF-alpha G0/G1 switch protein 2 MDM2/PROTAC Mcl-1 (stapled peptide) Bim (stapled peptide) Bcl-2 (stapled peptide) p53/MDM2 (stapled peptide)
Autophagy Autophagy CXCR LRRK2 ULK SPHK PPT mitoNEET TFEB
Cell Cycle APC Aurora Kinase BUB Casein Kinase CDK Chk c-Myc CRISPR/Cas9 CRM1 DHFR DNA/RNA Synthesis DYRK eIF G-quadruplex Haspin Kinase HSF HSP IRE1 Kinesin LIMK Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p21 PAK PD-1/PD-L1 PERK PLK PPAR PTEN RAD51 Rho ROCK Wee1 FOXM1 MKLP Cdc25 TACC DOCK Clathrin MARP Lats kinase
Cytoskeleton Akt Arp2/3 Complex Dynamin FAK Gap Junction Protein HSP Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK PKC Selectin Wnt β-catenin Spastin Gap Junction MLCK TACC
DNA Damage ATM/ATR DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK HDAC MTH1 PARP Sirtuin Telomerase Topoisomerase HDR OGG ATAD5
Endocrinology/Hormones 5 Alpha Reductase ACE Androgen Receptor Aromatase ERR Glucocorticoid Receptor GPCR Opioid Receptor Progesterone Receptor Renin TPO Thyroid Hormone Receptor
Epigenetics AMPK Aurora Kinase CECR2 DNA Methyltransferase Epigenetic Reader Domain HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PAD PARP Pim PKC Sirtuin TET MBD-containing protein EZH2 (stapled peptide) HES FTO
GPCR/G Protein Adenosine Receptor Adiponectin Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRTH2 CXCR Dopamine Receptor Endothelin Receptor GHSR Glucagon Receptor GNRH Receptor GPCR Guanylate Cyclase Hedgehog Histamine Receptor Imidazoline Receptor LPA Receptor LPL Receptor LTR mGluR Motilin Receptor MT Receptor Neuropeptide Y Receptor Neurotensin Receptor NK Receptor NMUR Opioid Receptor OX Receptor P2Y Receptor PAFR PAR PKA Prostaglandin Receptor Ras RGS SGLT Sigma Receptor SSTR TSH Receptor Urotensin Receptor Vasopressin Receptor HDR More >>
Immunology/Inflammation CCR Complement System COX CRTH2 CXCR FLAP Histamine Receptor IFNAR IL Receptor IRAK LTR MALT1 MyD88 NADPH Oxidase NLR NOS Nrf2 PD-1/PD-L1 PGE Synthase ROS SIK STING Thrombopoietin Receptor TLR LTA4H Calcineurin Complement Receptor IL Immunology & Inflammation Related IRF3 MIF S100A9 TSPO cGAS macrophage/microglia NFAT FPR CYPA CD80 Scavenger receptor NOT CD28-B7 Endorphin LanC-like protein S100β PG Synthase XBP1
JAK/STAT Signaling EGFR JAK Pim STAT
LIF/Stat3 LIF
MAPK/ERK Pathway ERK JNK KLF MEK MLK MNK p38 MAPK Raf RSK MAP4K4 AP-1
Membrane Transporter/Ion Channel AMPAR ATPase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT1 HCN Channel MAT MCT Na+/Ca2+ Exchanger Na+/K+ ATPase NBC NKCC NMDAR Oct P2X Receptor P-gp Potassium Channel Proton Pump SGLT Sodium Channel TRPV URAT1 VDAC EAAT1 IBAT TRP Channel AChR SLC Glutamate transporter UCP ENT GABA transporter Glycine transporter Kainate receptor ABC Transporter ANT AKK1 Efflux pump Clathrin Piezo OCTN
Metabolic Enzyme Adenosine Deaminase AhR ALDH Aldose Reductase Aminopeptidase ATP Citrate Lyase Carbonic Anhydrase Cathepsin CETP COMT CPA Decarboxylase Dehydrogenase DGAT DHFR Elastase Enolase FAAH FABP Factor Xa FAS Ferroptosis FXR Glucokinase GLUT1 GSNOR GST Hexokinase HIF HIV Integrase HMGCR HSP Hydroxylase IDH IDO Lipase Lipoxygenase LXR MAO Mineralocorticoid Receptor NAE NAMPT Neprilysin P450 PAI-1 PDE PDHK PGC-1α Phospholipase More >>
Neuronal Signaling AChE AMPAR Amyloid-β CaMK CGRP Receptor COMT COX DAT Dopamine Receptor FAAH GABA Receptor GlyT1 Histamine Receptor Imidazoline Receptor MAO mGluR MT Receptor NK Receptor NMDAR Opioid Receptor OX Receptor P2X Receptor P-gp Secretase SSRIs Substance P Choline Cholinesterase Enkephalinase Glucosylceramide Synthase NET PSD-95 RAGE SERT 5-HT Receptor AChR Adenosine Kinase Adrenergic Receptor Proprotein convertases QC AQP4 CHT GABA transporter Glycine transporter Kainate receptor Endorphin
PI3K/Akt/mTOR Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN RSK FOXO PHLPP PDK
Protease Caspase Cysteine Protease DPP4 Glutaminase HIV Protease MMP Proteasome Secretase Ser/Thr Protease Tyrosinase Aspartic Protease NEP 3CLpro DPP2 SUMO
Protein Tyrosine Kinase/RTK Ack1 ALK BMX Kinase BTK c-FMS c-Kit c-Met/HGFR c-RET DDR1/DDR2 Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 HER2 IGF-1R Insulin Receptor ITK PDGFR PKA PTK Pyk2 Ros1 Src Syk TAM Receptor Tie-2 Trk Receptor VEGFR BRK Bcr-Abl MERTK FGF Tec ErbB
TGF-beta/Smad Bcr-Abl PKC TGF-beta Receptor TGF-beta Smad MARP
Stem Cells/Wnt BMI-1 Casein Kinase ERK Gli GSK-3 Hedgehog JAK MST Notch PKA PORCN ROCK Secretase sFRP-1 Smo STAT Wnt YAP β-catenin CREB β-catenin (stapled peptide) Notch (stapled peptide) PKA/AKAP (stapled peptide) LIN28 MARP LRH-1
Ubiquitin APC DUB E1/E2/E3 Enzyme NAE p97 Proteasome MDM2 SUMO FBXO
Phosphatase
NF-κB HDAC IKK MALT1 NF-κB Nrf2 PPAR RIP Kinase TAK1
Biochemical Reagent Intermediate and Others Biochemical Assay Reagent Dye Reagent
PROTAC E1/E2/E3 Enzyme Multikinase/PROTAC Others
Stapled Peptide Mcl-1 (stapled peptide) β-catenin (stapled peptide) EZH2 (stapled peptide) SOS1/KRAS (stapled peptide) Notch (stapled peptide) PKA/AKAP (stapled peptide) Beclin 1 (stapled peptide) Bim (stapled peptide) Bcl-2 (stapled peptide) p53/MDM2 (stapled peptide) RAP1/TRF2 (stapled peptide) Rab (stapled peptide) VDR (stapled peptide) β-arrestin/β-adaptin (stapled peptide)
Others Phosphorylase SRPK VDA Anti-ulcer Cancer Stem Cells CD73 CerK Choline Kinase Diuretic ECE FANCJ Fer/FerT FPP synthase Fucosyltransferase Galectin-3 GBF1 GCase HPPD Importin β Insecticide ITPKA LAT1 MLKL MPO MPTP MTTP Muscle Relaxant NMD NO Synthesis Nur77 Osteoclasts/Bone/Osteogenesis OxPhos PCSK9 PFKFB3 PIN1 PKG Platelet PME-1 Protein Synthesis Rev-ErbA SQS SREBP Sweetener Tgase Urease XOR Chelating Agent CAR Legumain More >>

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The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. The ErbB protein family consists of 4 members: ErbB-1, also named epidermal growth factor receptor (EGFR); ErbB-2, also named HER2 in humans and neu in rodents; ErbB-3, also named HER3; ErbB-4, also named HER4.

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