欢迎来到 CSNpharm! 产品仅用于科研!
首页 Compound Arrays 促销产品
400-920-2911 sales@csnpharm.cn    

ERK

ERK

货号 产品名 CAS号 信息
CSN16763 XMD8-92 1234480-50-2 XMD8-92 is an inhibitor of ERK5/BMK1. The Kd values for BMK1, DCAMKL2, PLK4 and TNK1 are 80 nM, 190 nM, 600 nM and 890 nM respectively.
CSN17855 XMD17-109 1435488-37-1 XMD17-109 is a specific ERK-5 inhibitor with an EC50 4.2 μM in HEK293 cells.
CSN18540 VX-11e 896720-20-0 VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
CSN25710 TMCB 905105-89-7 TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM.
CSN13154 Tauroursodeoxycholate Sodium 35807-85-3 Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells.
CSN21082 MK-8353 1184173-73-6 MK-8353, also known as SCH900353, is a potent and orally active ERK1/2 inhibitor and anticancer drug candidate currently being developed by Schering-Plough. MK-8353 exhibited comparable potency with SCH772984 across various preclinical cancer models.
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN13064 FR 180204 865362-74-9 FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 μM and 0.14 μM respectively and has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
CSN26645 SKI V 24418-86-8 for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].
CSN17601 ERK5-IN-1 1234479-76-5 ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.
CSN18045 DEL-22379 181223-80-3 DEL-22379 inhibits ERK dimerization with IC50 of 0.5 μM.
CSN24804 BCI-215   1245792-67-9 BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells. BCI-215 induced rapid and sustained phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in the absence of reactive oxygen species, and its toxicity was partially rescued by inhibition of p38 but not JNK or ERK.
CSN27196 BAY-885   2307249-33-6 BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM.
CSN21221 AG-126 118409-62-4 AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM.
<< PREV 1 NEXT >>