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ERK

ERK

货号 产品名 CAS号 信息
CSN16763 XMD8-92 1234480-50-2 XMD8-92 is an inhibitor of ERK5/BMK1. The Kd values for BMK1, DCAMKL2, PLK4 and TNK1 are 80 nM, 190 nM, 600 nM and 890 nM respectively.
CSN17855 XMD17-109 1435488-37-1 XMD17-109 is a specific ERK-5 inhibitor with an EC50 4.2 μM in HEK293 cells.
CSN18540 VX-11e 896720-20-0 VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent.
CSN15784 Ulixertinib 869886-67-9 Ulixertinib is a potent and reversible ERK1/ERK2 inhibitor with IC50 of < 0.3 nM for ERK2.
CSN23392 Ulixertinib hydrochloride 1956366-10-1 Ulixertinib HCl, the salt of ulixertinib, is a reversible inhibitor of ERK1/ERK2. It can inhibit cell proliferation.
CSN25204 trans-Zeatin 1637-39-4 trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
CSN25710 TMCB 905105-89-7 TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM.
CSN13154 Tauroursodeoxycholate sodium 35807-85-3 Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells.
CSN13643 SCH772984 942183-80-4 SCH772984 is a specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
CSN13112 Orcinol glucoside 21082-33-7 Sakakin, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn, can improve depressive behaviour in chronic unpredictable mild stress (CUMS) rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.
CSN33183 Rineterkib 1715025-32-3 Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.
CSN33184 Rineterkib hydrochloride 1715025-34-5 Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.
CSN17141 Pluripotin 839707-37-8 Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. It maintains embryonic stem cell (ESC) self-renewal.
CSN11644 Pachymic acid 29070-92-6 Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties.
CSN26520 Mps1-IN-1 dihydrochloride 1883548-93-3 Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1].
CSN21082 MK-8353 1184173-73-6 MK-8353, also known as SCH900353, is a potent and orally active ERK1/2 inhibitor and anticancer drug candidate currently being developed by Schering-Plough. MK-8353 exhibited comparable potency with SCH772984 across various preclinical cancer models.
CSN20623 Temuterkib 1951483-29-6 LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM.
CSN24745 Longdaysin 1353867-91-0 Longdaysin inhibited CKIδ, CKIα, ERK2 and CDK7 with IC50 values of 8.8, 5.6, 52, and 29μM, respectively. The EC50 values of longdaysin for CKIδ and CKIα in the cell-based PER1 degradation assay were 9.7 and 9.2μM, respectively.
CSN22441 KO-947 1695533-89-1 KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors.
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN16271 Ravoxertinib 1453848-26-4 GDC-0994 is highly selective for ERK1 and ERK2, with IC50 of 1.1 nM and 0.3 nM, respectively.
CSN19017 Ravoxertinib hydrochloride 2070009-58-2 GDC-0994 HCl is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively.
CSN13064 FR 180204 865362-74-9 FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 μM and 0.14 μM respectively and has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
CSN26645 SKI V 24418-86-8 for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].
CSN24288 ERK5-IN-2 1888305-96-1 ERK5-IN-2 is a selective ERK5 inhibitor with IC50 value of 0.82 μM.
CSN17601 ERK5-IN-1 1234479-76-5 ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.
CSN18045 DEL-22379 181223-80-3 DEL-22379 inhibits ERK dimerization with IC50 of 0.5 μM.
CSN13519 Corynoxeine 630-94-4 Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation, and is a useful and prospective compound in the prevention and treatment for vascular diseases.
CSN22365 CC-90003 1621999-82-3 CC-90003 is an irreversible inhibitor of ERK 1/2 with antitumor activity.
CSN20512 Cafestol 469-83-0 Cafestol is a bioactive substance isolated and extracted from coffee with potential medical uses.
CSN24804 BCI-215   1245792-67-9 BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells. BCI-215 induced rapid and sustained phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in the absence of reactive oxygen species, and its toxicity was partially rescued by inhibition of p38 but not JNK or ERK.
CSN27196 BAY885   2307249-33-6 BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM.
CSN21094 Tizaterkib 2097416-76-5 AZD0364 is an ERK1 and​/or ERK2 kinase for the treatment of cancer.
CSN22695 AX-15836 2035509-96-5 AX 15836 is a potent and selective ERK5 inhibitor with IC50 of 8 nM.
CSN27671 ASTX029   2095719-92-7 ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity.
CSN19016 APS-2-79 2002381-25-9 APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
CSN21221 AG126 118409-62-4 AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM.
CSN64535 Pamoic acid disodium 6640-22-8
CSN68211 GSK143 1240390-27-5
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