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ERK
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN16763 | XMD8-92 | 1234480-50-2 | XMD8-92 is an inhibitor of ERK5/BMK1. The Kd values for BMK1, DCAMKL2, PLK4 and TNK1 are 80 nM, 190 nM, 600 nM and 890 nM respectively. |
CSN17855 | XMD17-109 | 1435488-37-1 | XMD17-109 is a specific ERK-5 inhibitor with an EC50 4.2 μM in HEK293 cells. |
CSN18540 | VX-11e | 896720-20-0 | VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent. |
CSN15784 | Ulixertinib | 869886-67-9 | Ulixertinib is a potent and reversible ERK1/ERK2 inhibitor with IC50 of < 0.3 nM for ERK2. |
CSN23392 | Ulixertinib hydrochloride | 1956366-10-1 | Ulixertinib HCl, the salt of ulixertinib, is a reversible inhibitor of ERK1/ERK2. It can inhibit cell proliferation. |
CSN25204 | trans-Zeatin | 1637-39-4 | trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation. |
CSN12111 | Tomatidine | 77-59-8 | Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. |
CSN25710 | TMCB | 905105-89-7 | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM. |
CSN13154 | Tauroursodeoxycholate sodium | 35807-85-3 | Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells. |
CSN13643 | SCH772984 | 942183-80-4 | SCH772984 is a specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
CSN13112 | Orcinol glucoside | 21082-33-7 | Sakakin, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn, can improve depressive behaviour in chronic unpredictable mild stress (CUMS) rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus. |
CSN33183 | Rineterkib | 1715025-32-3 | Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. |
CSN33184 | Rineterkib hydrochloride | 1715025-34-5 | Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. |
CSN17141 | Pluripotin | 839707-37-8 | Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. It maintains embryonic stem cell (ESC) self-renewal. |
CSN11644 | Pachymic acid | 29070-92-6 | Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties. |
CSN26520 | Mps1-IN-1 dihydrochloride | 1883548-93-3 | Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1]. |
CSN21082 | MK-8353 | 1184173-73-6 | MK-8353, also known as SCH900353, is a potent and orally active ERK1/2 inhibitor and anticancer drug candidate currently being developed by Schering-Plough. MK-8353 exhibited comparable potency with SCH772984 across various preclinical cancer models. |
CSN20623 | Temuterkib | 1951483-29-6 | LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM. |
CSN24745 | Longdaysin | 1353867-91-0 | Longdaysin inhibited CKIδ, CKIα, ERK2 and CDK7 with IC50 values of 8.8, 5.6, 52, and 29μM, respectively. The EC50 values of longdaysin for CKIδ and CKIα in the cell-based PER1 degradation assay were 9.7 and 9.2μM, respectively. |
CSN22441 | KO-947 | 1695533-89-1 | KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors. |
CSN14412 | Hirsutenone | 41137-87-5 | Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM. |
CSN16271 | Ravoxertinib | 1453848-26-4 | GDC-0994 is highly selective for ERK1 and ERK2, with IC50 of 1.1 nM and 0.3 nM, respectively. |
CSN19017 | Ravoxertinib hydrochloride | 2070009-58-2 | GDC-0994 HCl is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively. |
CSN13064 | FR 180204 | 865362-74-9 | FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 μM and 0.14 μM respectively and has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively. |
CSN26645 | SKI V | 24418-86-8 | for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2]. |
CSN24288 | ERK5-IN-2 | 1888305-96-1 | ERK5-IN-2 is a selective ERK5 inhibitor with IC50 value of 0.82 μM. |
CSN17601 | ERK5-IN-1 | 1234479-76-5 | ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM. |
CSN18045 | DEL-22379 | 181223-80-3 | DEL-22379 inhibits ERK dimerization with IC50 of 0.5 μM. |
CSN13519 | Corynoxeine | 630-94-4 | Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation, and is a useful and prospective compound in the prevention and treatment for vascular diseases. |
CSN22365 | CC-90003 | 1621999-82-3 | CC-90003 is an irreversible inhibitor of ERK 1/2 with antitumor activity. |
CSN20512 | Cafestol | 469-83-0 | Cafestol is a bioactive substance isolated and extracted from coffee with potential medical uses. |
CSN24804 | BCI-215 | 1245792-67-9 | BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells. BCI-215 induced rapid and sustained phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in the absence of reactive oxygen species, and its toxicity was partially rescued by inhibition of p38 but not JNK or ERK. |
CSN27196 | BAY885 | 2307249-33-6 | BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM. |
CSN21094 | Tizaterkib | 2097416-76-5 | AZD0364 is an ERK1 and/or ERK2 kinase for the treatment of cancer. |
CSN22695 | AX-15836 | 2035509-96-5 | AX 15836 is a potent and selective ERK5 inhibitor with IC50 of 8 nM. |
CSN27671 | ASTX029 | 2095719-92-7 | ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity. |
CSN19016 | APS-2-79 | 2002381-25-9 | APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. |
CSN21221 | AG126 | 118409-62-4 | AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. |
CSN64535 | Pamoic acid disodium | 6640-22-8 | |
CSN68211 | GSK143 | 1240390-27-5 |