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FAK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17077 | Y15 | 4506-66-5 | Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK. |
| CSN20842 | Solanesol | 13190-97-1 | Solanesol is a C45 isoprenoid alcohol, it is the most abundant lipid in tobacco leaves and may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke. |
| CSN28454 | PROTAC FAK degrader 1 | 2301916-69-6 | PROTAC FAK degrader 1 is a selective and potent PROTAC targeting on Fak with DC50 value of 3nM. It was generated by linking defactinib and VHL ligand. |
| CSN16593 | PND-1186 | 1061353-68-1 | PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM. |
| CSN16483 | PF-573228 | 869288-64-2 | PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK phosphorylation on Tyr(397) with an IC(50) of 30-100 nM. |
| CSN16016 | PF-562271 | 717907-75-0 | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| CSN19192 | PF-562271 hydrochloride | 939791-41-0 | PF-562271 HCl is the HCl salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| CSN13737 | PF-562271 besylate | 939791-38-5 | PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| CSN13426 | PF-431396 | 717906-29-1 | PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4. |
| CSN13117 | NVP-TAE 226 | 761437-28-9 | NVP-TAE 226 is a potent FAK inhibitor with IC50 of 5.5 nM, modestly potent to Pyk2 (IC50=3.5 nM) and 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. |
| CSN26520 | Mps1-IN-1 dihydrochloride | 1883548-93-3 | Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1]. |
| CSN18810 | GSK2256098 | 1224887-10-8 | GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
| CSN28517 | FC-11 | 2271035-37-9 | FC-11 is a potent FAK-targeting PROTAC. FC-11 showed a rapid and reversible FAK degradation with a picomolar of DC50 in various cell lines in vitro, which imply that FAK-PROTACs could be useful as expand tools for studying functions of FAK in biological system and as potential therapeutic agents. |
| CSN26649 | FAK inhibitor 5 | 1426683-30-8 | FAK inhibitor 5 (compound 2) is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range[1]. |
| CSN17445 | Defactinib | 1073154-85-4 | Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway. |
| CSN17446 | Defactinib hydrochloride | 1073160-26-5 | Defactinib HCl is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway. |
| CSN16269 | CTX-0294885 | 1439934-41-4 | CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen. |
| CSN16907 | CEP-37440 | 1391712-60-9 | CEP-37440 is a potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma). |
| CSN23887 | BI-4464 | 1227948-02-8 | BI-4464 is a ATP competitive inhibitor of focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM. |
| CSN64533 | Solanesol | 13190-97-1 | |
| CSN51388 | AMP-945 | 1393653-34-3 | |
| CSN51420 | APG-2449 | 2196186-84-0 |
