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FAK

FAK

货号 产品名 CAS号 信息
CSN17077 Y15 4506-66-5 Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.
CSN20842 Solanesol 13190-97-1 Solanesol is a C45 isoprenoid alcohol, it is the most abundant lipid in tobacco leaves and may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke.
CSN28454 PROTAC FAK degrader 1 2301916-69-6 PROTAC FAK degrader 1 is a selective and potent PROTAC targeting on Fak with DC50 value of 3nM. It was generated by linking defactinib and VHL ligand.
CSN16593 PND-1186 1061353-68-1 PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.
CSN16483 PF-573228 869288-64-2 PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK phosphorylation on Tyr(397) with an IC(50) of 30-100 nM.
CSN16016 PF-562271 717907-75-0 PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN19192 PF-562271 hydrochloride 939791-41-0 PF-562271 HCl is the HCl salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN13737 PF-562271 besylate 939791-38-5 PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN13426 PF-431396 717906-29-1 PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.
CSN13117 NVP-TAE 226 761437-28-9 NVP-TAE 226 is a potent FAK inhibitor with IC50 of 5.5 nM, modestly potent to Pyk2 (IC50=3.5 nM) and 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
CSN26520 Mps1-IN-1 dihydrochloride 1883548-93-3 Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1].
CSN18810 GSK2256098 1224887-10-8 GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
CSN28517 1-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-N-(4-((4-(((2-(N-methylmethylsulfonamido)pyridin-3-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazole-4-carboxamide 2271035-37-9 FC-11 is a potent FAK-targeting PROTAC. FC-11 showed a rapid and reversible FAK degradation with a picomolar of DC50 in various cell lines in vitro, which imply that FAK-PROTACs could be useful as expand tools for studying functions of FAK in biological system and as potential therapeutic agents.
CSN26649 FAK inhibitor 5 1426683-30-8 FAK inhibitor 5 (compound 2) is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range[1].
CSN17445 Defactinib 1073154-85-4 Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.
CSN17446 Defactinib hydrochloride 1073160-26-5 Defactinib HCl is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.
CSN16907 CEP-37440 1391712-60-9 CEP-37440 is a potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma).
CSN23887 BI-4464 1227948-02-8 BI-4464 is a ATP competitive inhibitor of focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM.
CSN64533 Solanesol 13190-97-1
CSN51388 AMP-945 1393653-34-3
CSN51420 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(1-(tetrahydro-2H-pyran-4-yl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 2196186-84-0
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