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Flavonoids

Flavonoids

货号 产品名 CAS号 信息
CSN19343 Tricin 520-32-1 Tricin, a natural product isolated and purified from the herb of Avena sativa, is evaluated as a type of tyrosinase inhibitor, exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis, and is with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication.
CSN19343 Tricin 520-32-1 Tricin, a natural product isolated and purified from the herb of Avena sativa, is evaluated as a type of tyrosinase inhibitor, exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis, and is with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication.
CSN12091 Tiliroside 20316-62-5 Tiliroside, a natural product isolated and purified from the herbs of Agrimonia pilosa Ledeb.
CSN14056 Tephrosin 76-80-2 Tephrosin, a natural product isolated and purified from the herbs of Derris robusta, may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2, and exerts antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells.
CSN14599 Salvigenin 19103-54-9 Salvigenin, a natural product isolated and purified from the roots of Salvia japonica, with antitumor and immunomodulatory effects, reduces tumor cell growth in RIN cell line, and also inhibits the growth of tumor tissue in vivo.
CSN20945 Robustaflavone 49620-13-5 Robustaflavone is a naturally occurring biflavanoid isolated from rhus succedanea, it can be act as an inhibitor of hepatitis B virus replication.
CSN12572 Rhoifolin 17306-46-6 Rhoifolin, a natural product isolated and purified from the leaves of Turpinia arguya Seem, hows monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines, and may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.
CSN16618 Quercitrin 522-12-3 Quercitrin, a natural product isolated and purified from the herb of Apocynum venetum L.
CSN20977 Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside 60778-02-1 Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside is a natural product from desurainia sophia.
CSN11777 Procyanidin A2 41743-41-3 Procyanidin A2, a natural product isolated and purified from the rhizomes of Belamcanda chinensis (L.) DC., blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression, and has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO.
CSN19384 Pinostrobin 480-37-5 Pinostrobin, a natural product isolated and purified from the herbs of Cajanus cajan with anti-inflammatory, cytotoxic, anti-hemorrhagic and analgesic activities, exerts a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis, and can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 ug/mL.
CSN19325 Orobol 480-23-9 Orobol, a natural product isolated and purified from the herb of Wisteria sinensis, has sensitization effect may be by mitochondrial alterations in these cells, produces cisplatin sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway, and regulate PX sensitivity by reciprocally altering the proportion of tubulin isotype expression and PX-induced apoptotic signaling.
CSN19874 Orientin 28608-75-5 Orientin, a natural product isolated and purified from the herbs of Polygonum orientale Linn., is a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway, protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases, has neuroprotection effect by the intracellular mediation of caspase activity and may alleviate cognitive deficits and oxidative stress in AD mice and can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.
CSN20967 Nepitrin 569-90-4 Nepitrin is isolated from salvia plebeia R.Br. with antioxidant activity.
CSN22079 Quercetin-3-O-glucuronide 22688-79-5 Miquelianinis a metabolite of quercetin and a type of natural flavonoid which blocks β2-adrenergic signaling.
CSN21052 Methylophiopogonone B 74805-89-3 Methylophiopogonone B is a natural product from ophiopogon japonicus.
CSN14398 Medicarpin 32383-76-9 Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand.
CSN14313 Licoricidin 30508-27-1 Licoricidin, a natural product isolated and purified from the roots of Glycyrrhiza uralensis., inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis., and also blocks UVA-induced photoaging via ROS scavenging,this activity converges to limit the activity of MMP-1, suggests that licoricidin may be considered as an active ingredient in topically applied anti-ageing formulations.
CSN22080 Kuwanon A 62949-77-3 Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.) and inhibits nitric oxide production with IC50 of 10.5 μM.
CSN21038 Flemiphilippinin D 99119-72-9 Kushenol E can be found in the roots of sophora flavescens Ait. With significant antioxidant potentials.
CSN13417 Kaempferol 3-O-Arabinoside 5041-67-8 Kaempferol 3-O-arabinoside is a natural product isolated and purified from the roots of Ligusticum jeholense Nakai et Kitag displaying cytotoxic and high antioxidant activity.
CSN14309 Juglanin 5041-67-8 Juglanin, a natural product isolated and purified from the herbs of Phymatopteris hastate with antioxidant activity, shows protective effects on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats, and can lead to G2/M phase arrest, induce apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells, it may be a promising candidate for development of anti-tumor drugs targeting breast cancer.
CSN14616 Isoangustone A 129280-34-8 Isoangustone A, a natural product isolated and purified from the roots of Licorice with antitumor activity, induces G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma and shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
CSN16383 Hesperetin 520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN19988 Herbacetin 527-95-7 Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.
CSN14614 Glabrene 60008-03-9 Glabrene, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with estrogen-like activity, can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC), exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that it may serve as candidates for skin-lightening agents.
CSN14614 Glabrene 60008-03-9 Glabrene, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with estrogen-like activity, can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC), exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that it may serve as candidates for skin-lightening agents.
CSN15649 Gallocatechin Gallate 5127-64-0 Gallocatechin gallate is a natural product isolated and purified from the herbs of Celastrus orbiculatus with strong antioxidative activity, can decrease osteoclastogenesis at 20 mM, it has positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations, have anti-diabetic effects by increasing sensitivity of insulin, and gallocatechin gallate is more active than epigallocatechin gallate.
CSN10136 Farrerol 24211-30-1 Farrerol is a natural product isolated and purified from the leaves of Rhododendron dauricum L.
CSN19340 Eupatorin 855-96-9 Eupatorin, a natural product isolated and purified from the herbs of Eupatorium semiserratum, inhibits cell proliferation in human tumor cells, has meaningful anti-inflammatory property which may be utilized in the development of anti-inflammatory treatments, and induces cell death imediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation.
CSN14294 Dalbergioidin 30368-42-4 Dalbergioidin, a natural product isolated and purified from the roots of Parochetus communis with tyrosinase inhibitory activity with an IC50 of 20 mM, shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism, protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, and ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.
CSN20844 Camelliaside A 135095-52-2 Camelliaside A is a flavonol triglycoside isolated from seeds of Camellia sinensis.
CSN14837 Boeravinone B 114567-34-9 Boeravinone B is a natural product isolated and purified from the roots of Boerhaavia coccinea, exhibits significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model ,and is an efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S.
CSN10276 Amentoflavone 1617-53-4 Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM.
CSN11242 Afzelin 482-39-3 Afzelin is a natural product isolated and purified from the herbs of thesium chinense Turcz.
CSN14057 8-Prenylnaringenin 53846-50-7 8-Prenylnaringenin is a phytoestrogen isolated and purified from the herbs of Humulus lupulus with the highest estrogenic activity, shows slight activity in this assay but significant activity by immunostaining, improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle, and has more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein.
CSN14303 8-Prenylkaempferol 28610-31-3 8-Prenylkaempferol, a natural product isolated and purified from the roots of Sophora flavescens, is an effective agent for attenuating pro-inflammatory NO induction, induces differentiation/maturation of MC3T3-E1 osteoblasts by BMP-2/p38/Runx2 pathways, and may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and IRF-3 and in part by interfering with IκB degradation which subsequently decreases NF-κB translocation.
CSN20926 8-Hydroxyapigenin 41440-05-5 8-Hydroxyapigenin is a flavone found in cupuaçu (Theobroma grandiflorum) and in the liverwort marchantia berteroana.
CSN25205 7-Hydroxyflavone 6665-86-7 7-Hydroxyflavone is a flavonoid isolated from M. indica, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway .
CSN13049 5,7-Dihydroxychromone 31721-94-5 5,7-Dihydroxychromone, a natural product isolated and purified from the bark of Garcinia cambogia., exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal, and induces the translocation of Nrf2 to the nucleus and increases Nrf2/ARE binding activity which results in the up-regulation of the expression of Nrf2-dependent antioxidant genes, including HO-1, NQO1, and GCLc.
CSN12257 2'-Hydroxygenistein 1156-78-1 2'-hydroxygenistein, a natural product isolated and purified from the roots of Lupinus mutabilis with antifungal activity, exhibits greater antiproliferative effects in MCF-7 human breast cancer cells than does genistein, and shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B.
CSN13377 2'-Hydroxydaidzein 7678-85-5 2'-Hydroxydaidzein is an isoflavonoid phytoalexin isolated and purified from the herbs of Crotalaria pallida.
CSN13384 2',3,5,6',7-Pentahydroxyflavanone 80366-15-0 2',3,5,6',7-Pentahydroxyflavanone is a natural product isolated and purified from the roots of Scutellaria baicalensis Georgi which can inhibit the histamine release from rat mast cells induced by compound 48/80.
CSN27563 (±)-Naringenin 67604-48-2 (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
CSN14006 (-)-Maackiain 2035-15-6 (-)-Maackiain is a phytoalexin isolated and purified from the flowers of Maackia amurensis Rupr.et Maxim., shows significant growth inhibitory action on the growth of the human lymphoblastoid cell lines Molt and Raji.
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