Fms-like Tyrosine Kinase 3 | Protein Tyrosine Kinase/RTK| CSNpharm

FLT3

FLT3
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货号	产品名	CAS号	信息
CSN13941	TCS 359	301305-73-7	TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM.
CSN20533	SU-5614	1055412-47-9	SU-5614 is an inhibitor of FLT3. In Ba/F3 and AML cell lines expressing a constitutively activated FLT3, SU-5614 exhibits significant cell growth inhibition and cell cycle arrest.
CSN18820	Crotonoside	1818-71-9	Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.
CSN18365	AST-487	630124-46-8	AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
CSN22654	5'-Fluoroindirubinoxime	861214-33-7	5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) with IC50 of 15 nM.