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FXR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN13148 | Turofexorate isopropyl | 629664-81-9 | WAY-362450 is an agonist of farnesoid X receptor (FXR) with EC50 of 4 nM. WAY-362450 is used to the treatment of dyslipidemia. |
| CSN26168 | Vonafexor | 1192171-69-9 | Vonafexor is a farnesoid X receptor agonist. |
| CSN23688 | Tropifexor | 1383816-29-2 | Tropifexor is a potent agonist of FXR with EC50 of 0.26 nM. |
| CSN26485 | Tauro-β-muricholic acid sodium | 145022-92-0 | Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3]. |
| CSN15954 | T0901317 | 293754-55-9 | T0901317 is a selective agonist for LXR and FXR with EC50 of 50 nM and 5 μM, respectively. |
| CSN26448 | PX20606 trans racemate | 1268244-85-4 | PX20606, also known as PX-102, is a FXR agonist. PX20606 induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. PX20606 demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species. |
| CSN12883 | Obeticholic acid | 459789-99-2 | Obeticholic acid is a selective FXR agonist with EC50 of 99 nM and it has anticholestatic activity. |
| CSN21073 | Nidufexor | 1773489-72-7 | Nidufexor is a potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders. |
| CSN23776 | LY2562175 | 1103500-20-4 | LY2562175 is a selective and partial FXR agonist with EC50 of 193 nM. |
| CSN17377 | INT-767 | 1000403-03-1 | INT-767 is a potent agonist for both FXR (mean EC50, 30 nM by PerkinElmer AlphaScreen assay) and TGR5 (mean EC50, 630 nM by time resolved-fluorescence resonance energy transfer). |
| CSN11129 | GW 4064 | 278779-30-9 | GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). |
| CSN25374 | Guggulsterone | 95975-55-6 | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. |
| CSN15997 | Fexaramine | 574013-66-4 | Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. |
| CSN28427 | (Z)-Guggulsterone | 39025-23-5 | (Z)-Guggulsterone is a broad spectrum steroid receptor ligand and an antagonist of FXR with antiseptic, antirheumatic and anti-inflammatory activity in vivo. |
| CSN22796 | DY268 | 1609564-75-1 |
