Glucokinase | Metabolic Enzyme| CSNpharm

Glucokinase

Glucokinase
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货号	产品名	CAS号	信息
CSN18191	RO-28-1675	300353-13-3	Ro 28-1675 is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 μM.
CSN22238	PF-04991532	1215197-37-7	PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
CSN26253	Nerigliatin	1245603-92-2	PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 μM, which is under development for the treatment of type 2 diametes mellitus.
CSN26447	MK-0941	1137916-97-2	MK-0941 mesylate is a glucokinase activator (GKA) potentially for the treatment of type 2 diabetes. MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood.
CSN16830	Globalagliatin	1234703-40-2	LY2608204 is an activator of glucokinase (GK) with EC50 of 42 nM.
CSN22830	GKA50	851884-87-2	GKA 50 is a potent glucokinase activator with EC50 of 33 nM.
CSN20177	Dorzagliatin	1191995-00-2	Dorzagliatin is a glucokinase activator on glucose metabolism.
CSN21071	AMG-3969	1361224-53-4	AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity.
CSN19038	AM-2394	1442684-77-6	AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.