Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family. In the brain, EAATs remove glutamate from the synaptic cleft and extrasynaptic sites via glutamate reuptake into glial cells and neurons, while VGLUTs move glutamate from the cell cytoplasm into synaptic vesicles. Glutamate transporters also transport aspartate and are present in virtually all peripheral tissues, including the heart, liver, testes, and bone. They exhibit stereoselectivity for L-glutamate but transport both L-aspartate and D-aspartate.
|CSN25809||MPDC||159262-32-5||MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter.|
|CSN25717||DL-TBOA||205309-81-5||DL-TBOA is a competitive and non-transportable blocker of excitatory amino acid transporters with IC50 values of 70, 6, 6, 4.4 and 3.2 μM for EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5 respectively.|
|CSN22753||Direct Blue 1||2610-05-1||Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles and also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 0.81 μM.|
|CSN22086||7-Chlorokynurenic acid sodium salt||1263094-00-3||7-Chlorokynurenic acid sodium salt is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with Ki of 0.59 μM.|
|CSN25716||rel-(3aR,6R,6aR)-3-Oxohexahydro-2H-pyrrolo[3,4-d]isoxazole-6-carboxylic acid||227619-65-0||(±)-HIP-B is non-competitive excitatory amino acid transporter (EAAT) blocker.|
|CSN25715||rel-(3aR,4S,6aR)-3-Oxohexahydro-2H-pyrrolo[3,4-d]isoxazole-4-carboxylic acid||227619-64-9||(±)-HIP-A is a non-competitive blocker of excitatory amino acid transporter (EAAT).|