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Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).

Glycine transporter

货号 产品名 CAS号 信息
CSN22250 Tilapertin 1000690-85-6 Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
CSN15699 N-Methylglycine 107-97-1 Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation.
CSN27664 rel-N-(3-Chloro-4-fluorobenzyl)-1-methyl-N-(((1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl)methyl)-1H-imidazole-4-carboxamide 1173239-39-8 PF-03463275 is a centrally penetrant, orally available, selective, and competitive inhibitor of GlyT1 (glycine transporter-1) with Ki of 11.6 nM. 
CSN23002 (Rac)-ALX 5407 405225-21-0 NFPS is a selective, non-transportable inhibitor of GlyT1 with IC50s of 2.8 and 9.8 nM for hGlyT1, rGlyT1.
CSN19019 LY2365109 HCl 1779796-27-8 LY2365109 is a selective inhibitor of GlyT1 with IC50 of 15.8 nM.
CSN22951 LY 2365109 hydrochloride 868265-28-5 LY 2365109 HCl is a potent and selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 15.8 nM.
CSN18458 Bitopertin (R enantiomer) 845614-12-2 Bitopertin R-enantiomer is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.
CSN13569 (S)-(4-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)(5-(methylsulfonyl)-2-((1,1,1-trifluoropropan-2-yl)oxy)phenyl)methanone 845614-11-1 Bitopertin is a noncompetitive inhibitor of glycine reuptake with IC50 of 25 nM.
CSN22690 ASP2535 374886-51-8 ASP 2535 is a potent and selective GlyT1 inhibitor with IC50 of 92 nM.
CSN10295 Amoxapine 14028-44-5 Amoxapine, a tricyclic dibenzoxazepine antidepressant, inhibits GLYT2a transport activity with IC50 of 92 μM.
CSN22675 ALX-5407 hydrochloride 200006-08-2 ALX 5407 HCl is a selective non-transportable inhibitor of the glycine transporter GlyT1 with IC50 of 3 nM for human GlyT1c.
CSN25812 (R)-2-(Methyl(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)amino)acetic acid 372198-97-5
CSN79211 Opiranserin HCl 1440796-75-7
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