Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).
|CSN15699||Sarcosine||107-97-1||Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation.|
|CSN27664||PF0346275||1173239-39-8||PF-03463275 is a centrally penetrant, orally available, selective, and competitive inhibitor of GlyT1 (glycine transporter-1) with Ki of 11.6 nM.|
|CSN23002||NFPS||405225-21-0||NFPS is a selective, non-transportable inhibitor of GlyT1 with IC50s of 2.8 and 9.8 nM for hGlyT1, rGlyT1.|
|CSN19019||LY2365109 HCl||1779796-27-8||LY2365109 is a selective inhibitor of GlyT1 with IC50 of 15.8 nM.|
|CSN18458||Bitopertin R-Enantiomer||845614-12-2||Bitopertin R-enantiomer is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.|
|CSN22690||ASP 2535||374886-51-8||ASP 2535 is a potent and selective GlyT1 inhibitor with IC50 of 92 nM.|