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Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).

Glycine transporter

货号 产品名 CAS号 信息
CSN15699 Sarcosine 107-97-1 Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation.
CSN27664 PF0346275 1173239-39-8 PF-03463275 is a centrally penetrant, orally available, selective, and competitive inhibitor of GlyT1 (glycine transporter-1) with Ki of 11.6 nM. 
CSN23002 NFPS 405225-21-0 NFPS is a selective, non-transportable inhibitor of GlyT1 with IC50s of 2.8 and 9.8 nM for hGlyT1, rGlyT1.
CSN19019 LY2365109 HCl 1779796-27-8 LY2365109 is a selective inhibitor of GlyT1 with IC50 of 15.8 nM.
CSN18458 Bitopertin R-Enantiomer 845614-12-2 Bitopertin R-enantiomer is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.
CSN22690 ASP 2535 374886-51-8 ASP 2535 is a potent and selective GlyT1 inhibitor with IC50 of 92 nM.
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