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Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22250 | Tilapertin | 1000690-85-6 | Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1). |
| CSN15699 | Sarcosine | 107-97-1 | Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation. |
| CSN27664 | PF-03463275 | 1173239-39-8 | PF-03463275 is a centrally penetrant, orally available, selective, and competitive inhibitor of GlyT1 (glycine transporter-1) with Ki of 11.6 nM. |
| CSN23002 | (Rac)-ALX 5407 | 405225-21-0 | NFPS is a selective, non-transportable inhibitor of GlyT1 with IC50s of 2.8 and 9.8 nM for hGlyT1, rGlyT1. |
| CSN19019 | LY2365109 hydrochloride | 1779796-27-8 | LY2365109 is a selective inhibitor of GlyT1 with IC50 of 15.8 nM. |
| CSN22951 | LY 2365109 HCl | 868265-28-5 | LY 2365109 HCl is a potent and selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 15.8 nM. |
| CSN18458 | Bitopertin (R enantiomer) | 845614-12-2 | Bitopertin R-enantiomer is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM. |
| CSN13569 | Bitopertin | 845614-11-1 | Bitopertin is a noncompetitive inhibitor of glycine reuptake with IC50 of 25 nM. |
| CSN22690 | ASP2535 | 374886-51-8 | ASP 2535 is a potent and selective GlyT1 inhibitor with IC50 of 92 nM. |
| CSN10295 | Amoxapine | 14028-44-5 | Amoxapine, a tricyclic dibenzoxazepine antidepressant, inhibits GLYT2a transport activity with IC50 of 92 μM. |
| CSN22675 | ALX 5407 hydrochloride | 200006-08-2 | ALX 5407 HCl is a selective non-transportable inhibitor of the glycine transporter GlyT1 with IC50 of 3 nM for human GlyT1c. |
| CSN25812 | (R)-2-(Methyl(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)amino)acetic acid | 372198-97-5 | |
| CSN79211 | Opiranserin hydrochloride | 1440796-75-7 |
