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GPCR

GPCR

货号 产品名 CAS号 信息
CSN25826 Zaprinast 37762-06-4 Zaprinast is selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).
CSN21886 Urotensin II (114-124), Human 251293-28-4 Urotensin II (114-124), human is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
CSN23913 TUG-1375 2247372-59-2 TUG-1375 is a free fatty acid receptor 2 (FFA2/GPR43) inhibitor with pKi of 6.69.
CSN23156 TC-O 9311 444932-31-4 TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM[1].
CSN24454 GPR39-C3 1621175-65-2 TC-G 1008 is a selective GPR39 agonist with EC50 value of 0.8 nM.
CSN25830 TC-G 1001 494191-73-0 TC-G 1001 is an agonist of GPR35.
CSN21830 Secretin (28-54), Human 108153-74-8 Secretin (28-54) (human) is an endogenous 27-amino acid gastrointestinal hormone and neuropeptide that regulates secretion from the stomach, pancreas, and liver.
CSN25229 SBI-115   882366-16-7 SBI-115 is a GPBAR1 (TGR5) antagonist.
CSN26356 Sb-756050 447410-57-3 SB756050 is an agonist of selective TGR5 and has the potential treatment of type 2 diabetes.
CSN26345 SB-657510 474960-44-6 SB-657510 is a selective urotensin II (UII) receptor antagonist with Ki value of 61 nM.
CSN51366 PW0787 2624131-45-7 PW0787 is an orally bioavailable, brain-penetrant, potent, and selective GPR52 agonist.
CSN25831 Prosaptide TX14(A) 196391-82-9 Prosaptide TX14(A) is a potent GPR37L1 and GPR37 agonist with EC50 values of 5 and 7 nM, respectively.
CSN24134 PMX 53 219639-75-5 PMX 53 is a potent C5a receptor antagonist.
CSN25834 PEN (rat) 569364-13-2 PEN (rat), a proSAAS-derived neuropeptide, is an agonist of endogenous peptide GPR83.
CSN25833 PEN (mouse) 1236955-25-1 PEN (mouse) is an endogenous peptide GPR83 agonist.
CSN25835 PEN (human) 597578-70-6 PEN (human) is agonist of endogenous peptide GPR83.
CSN25828 Pamoic acid disodium salt 6640-22-8 Pamoic acid disodium salt is agonist of GPR35, it can induce GPR35 internalization and activate ERK1/2 with EC50 values of 22 and 65 nM respectively.
CSN34909 ONC212 1807861-48-8 ONC212 is a fluorinated ONC201 analog. It was identified as activator of an orphan GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor.
CSN25832 Ogerin 1309198-71-7 Ogerin is a selective allosteric modulator of GPR68 with pEC50 of 6.83.
CSN25819 MS 21570 65373-29-7 MS 21570 is an antagonist of GPR171 with IC50 of 220 nM.
CSN25822 5-Methacrylamidoisophthalic acid 73912-52-4 MS 15203 is a selective GPR171 partial agonist with EC50 of 90 nM.
CSN25825 ML 194 264233-05-8 ML 194 is a competitive and reversible antagonist of the orphan receptor GPR35 with Ki of 12.8 nM.
CSN25824 ML 145 1164500-72-4 ML 145 is a selective antagonist of the GPR35 orphan receptor with IC50 of 20.1 nM.
CSN23711 MCHr1 Antagonist 1 391610-37-0 MCHr1 antagonist 1 is a selective antagonist of MCH1 receptor with Kb of 1 nM and Ki of 4 nM at human MCHR1, may be used to reduce the body mass.
CSN22054 Kisspeptin-10 374675-21-5 Kisspeptin-10 is a potent endogenous agonist for GPR54 and used as a vasoconstrictor and an angiogenesis inhibitor.
CSN25201 Hyodeoxycholic acid 83-49-8 Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
CSN33106 GPR35 antagonist 1 354126-20-8 GPR35 antagonist 1 is a GPR35 antagonist with IC50 value of 0.55μM.
CSN25587 g15 1161002-05-6 G15 is a high-affinity and selective GPER receptor antagonist with Ki value of 20nM.
CSN26204 FTBMT 1358575-02-6 FTBMT is a selective GPR52 agonist with an EC50 of 75 nM. It demonstrates antipsychotic-like and procognitive effects in rodents and has revealed a potential therapeutic agent for schizophrenia.
CSN25392 Deoxycholic acid sodium salt 302-95-4 Deoxycholic acid sodium salt is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
CSN44136 DA-1241 1914136-10-9 DA-1241 is a first-in-class GPR119 agonist which improved glucose control in patients with type 2 diabetes in US Phase 1b study.
CSN33237 CLP-3094 312749-73-8 CLP-3094 is a selective and potent GPR142 antagonist. It is also a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor.
CSN25821 BigLEN (rat) 369377-66-2 BigLEN (rat) is an agonist of GPR171 with EC50 of 1.6 nM.
CSN25820 BigLEN (mouse) 501036-69-7 BigLEN (mouse) is an agonist of GPR171.
CSN29508 N-acetyl-S-farnesyl-L-Cysteine 135304-07-3 Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.
CSN20400 AEZS-108 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN21960 A-779 159432-28-7 A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor.
CSN25414 3-chloro-5-hydroxybenzoic Acid 53984-36-4 3-chloro-5-hydroxybenzoic Acid is a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity.
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