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GSK-3

GSK-3

货号 产品名 CAS号 信息
CSN26734 VP3.15 dihydrobromide 1281681-33-1 VP3.15 Dihydrobromide is a novel dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor.
CSN15707 TWS119 601514-19-6 TWS119 is inhibitor of glycogen synthase kinase-3β with IC50 of 30 nM.
CSN16043 Tideglusib 865854-05-3 Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.
CSN19500 TDZD-8 327036-89-5 TDZD-8, the derivative of thiadiazolidinone, is a selective inhibitor of GSK-3. It inhibits GSK-3β with IC50 of 2 μM.
CSN23157 TCS2002 1005201-24-0 TCS-2002 is a Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.
CSN16568 SB 415286 264218-23-7 SB-415286 is an ATP-competitive inhibitor of GSK3α/GSK3β with IC50 of 78 nM and Ki of 31 nM.
CSN12268 SB 216763 280744-09-4 SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP.
CSN23154 TC-G 24 1257256-44-2 Potent and selective GSK-3β inhibitor
CSN18355 LY2090314 603288-22-8 LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
CSN67023 Lithium Chloride 7447-41-8 Lithium directly inhibits GSK3 by competitive binding for magnesium (Mg2+), disrupting the catalytic functioning of GSK3. Lithium also indirectly inhibits GSK3 by increasing serine phosphorylation, through P13K-mediated phosphorylation/activation of Akt.
CSN22886 Lithium carbonate 554-13-2 Lithium Carbonate inhibits GSK-3 in vivo.
CSN11250 Kenpaullone 142273-20-9 Kenpaullone is an ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 0.4 µM), CDK2/cyclin A (IC50 = 0.68 µM), CDK5/p25 (IC50 = 0.85 µM), lymphocyte kinase (IC50 = 0.47 µM) , and GSK-3β (C50 = 0.23 μM).
CSN11201 Indirubin-3'-monoxime 160807-49-8 Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM).
CSN17487 IM-12 1129669-05-1 IM-12 is a GSK-3β inhibitor with IC50 of 53 nM.
CSN23173 TWS119 Trifluoroacetate 1507095-58-0 GSK-3β inhibitor; induces neuronal differentiation in ESCs
CSN27222 GSK-3β inhibitor 2 1702428-31-6 GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease .
CSN18354 GSK-3 inhibitor 1 603272-51-1 GSK-3 inhibitor 1 is a potent GSK-3 inhibitor.
CSN24803 GNF4877   2041073-22-5 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively
CSN24779 EHT 1610 1425945-60-3 EHT 5372 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively.
CSN17624 CP21R7 125314-13-8 CP21R7 is a slective inhibitor of GSK-3β.
CSN13470 Laduviglusib   252917-06-9 CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, exhibiting > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
CSN19176 Laduviglusib monohydrochloride 1797989-42-4 CHIR-99021 HCl is HCl of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM and shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.
CSN19149 Laduviglusib trihydrochloride 1782235-14-6 CHIR-99021 3HCl is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, showing > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
CSN20636 CHIR 98024 556813-39-9 CHIR-98014 is a reversible inhibitor of GSK3α and GSK3β with IC50 of 0.65 nM and 0.58 nM, respectively.
CSN23355 CHIR-98014 252935-94-7 CHIR-98014 (CT98014) is highly selective aminopyrimidine-derivatived inhibitor of GSK-3 with IC50 of 650nM and 580nM for GSK-3 and GSK-3(measured by kinase assays), respectively, and exhibits >1000-fold selectivity for GSK-3 over closely related kinases, such as cdc2.
CSN16227 BIO-acetoxime 667463-85-6 BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM.
CSN16080 GSK 3 Inhibitor IX 667463-62-9 BIO is an inhibitor of GSK-3 and CDK1–cyclinB complex. The IC50s of GSK-3αβ, CDK1, CDK5 are 5 nM, 320 nM and 83 nM, respectively.
CSN13082 Bikinin 188011-69-0 Bikinin acts as an ATP-competitive inhibitor of arabidopsis GSK-3 and effective activator of brassinosteroid (BR) signaling.
CSN13894 AZD2858 486424-20-8 AZD2858 is an inhibitor of GSK-3 with IC50 of 68 nM that can inhibit the tau phosphorylation of S396 site and activate Wnt signaling pathway.
CSN16226 AZD1080 612487-72-6 AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
CSN15984 AR-A014418 487021-52-3 AR-A014418 is a selective inhibitor of GSK3β with IC50 of 104 ± 27 nM.
CSN26521 (Z)-SKI V 927429-51-4 and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1].
CSN22657 A 1070722 1384424-80-9 A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor with Ki of 0.6 nM for GSK-3α and GSK-3β.
CSN27603 9-ING-41 1034895-42-5 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
CSN23598 5-Bromoindole 10075-50-0 5-bromoindole is an inhibitor of glycogen synthase kinase 3 (GSK-3), it can be used as important pharmaceutical chemical intermediate.
CSN18742 1-Azakenpaullone 676596-65-9 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, > 100-fold selectivity over CDK1/cyclin B and CDK5/p25.
CSN78105 ZLWH-23 2765251-12-3
CSN84227 ABC1183 1042735-18-1
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