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GSK-3
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN26734 | VP3.15 dihydrobromide | 1281681-33-1 | VP3.15 Dihydrobromide is a novel dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor. |
CSN15707 | TWS119 | 601514-19-6 | TWS119 is inhibitor of glycogen synthase kinase-3β with IC50 of 30 nM. |
CSN16043 | Tideglusib | 865854-05-3 | Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively. |
CSN19500 | TDZD-8 | 327036-89-5 | TDZD-8, the derivative of thiadiazolidinone, is a selective inhibitor of GSK-3. It inhibits GSK-3β with IC50 of 2 μM. |
CSN23157 | TCS2002 | 1005201-24-0 | TCS-2002 is a Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. |
CSN16568 | SB 415286 | 264218-23-7 | SB-415286 is an ATP-competitive inhibitor of GSK3α/GSK3β with IC50 of 78 nM and Ki of 31 nM. |
CSN12268 | SB 216763 | 280744-09-4 | SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP. |
CSN23154 | TC-G 24 | 1257256-44-2 | Potent and selective GSK-3β inhibitor |
CSN18355 | LY2090314 | 603288-22-8 | LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively. |
CSN67023 | Lithium Chloride | 7447-41-8 | Lithium directly inhibits GSK3 by competitive binding for magnesium (Mg2+), disrupting the catalytic functioning of GSK3. Lithium also indirectly inhibits GSK3 by increasing serine phosphorylation, through P13K-mediated phosphorylation/activation of Akt. |
CSN22886 | Lithium carbonate | 554-13-2 | Lithium Carbonate inhibits GSK-3 in vivo. |
CSN11250 | Kenpaullone | 142273-20-9 | Kenpaullone is an ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 0.4 µM), CDK2/cyclin A (IC50 = 0.68 µM), CDK5/p25 (IC50 = 0.85 µM), lymphocyte kinase (IC50 = 0.47 µM) , and GSK-3β (C50 = 0.23 μM). |
CSN11201 | Indirubin-3'-monoxime | 160807-49-8 | Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). |
CSN17487 | IM-12 | 1129669-05-1 | IM-12 is a GSK-3β inhibitor with IC50 of 53 nM. |
CSN23173 | 3-((6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenol bis(2,2,2-trifluoroacetate) | 1507095-58-0 | GSK-3β inhibitor; induces neuronal differentiation in ESCs |
CSN27222 | GSK-3β inhibitor 2 | 1702428-31-6 | GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease . |
CSN18354 | GSK-3 inhibitor 1 | 603272-51-1 | GSK-3 inhibitor 1 is a potent GSK-3 inhibitor. |
CSN24803 | GNF4877 | 2041073-22-5 | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively |
CSN24779 | EHT 1610 | 1425945-60-3 | EHT 5372 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively. |
CSN17624 | CP21R7 | 125314-13-8 | CP21R7 is a slective inhibitor of GSK-3β. |
CSN13470 | Laduviglusib | 252917-06-9 | CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, exhibiting > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
CSN19176 | Laduviglusib monohydrochloride | 1797989-42-4 | CHIR-99021 HCl is HCl of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM and shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. |
CSN19149 | Laduviglusib trihydrochloride | 1782235-14-6 | CHIR-99021 3HCl is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, showing > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
CSN20636 | CHIR 98024 | 556813-39-9 | CHIR-98014 is a reversible inhibitor of GSK3α and GSK3β with IC50 of 0.65 nM and 0.58 nM, respectively. |
CSN23355 | CHIR-98014 | 252935-94-7 | CHIR-98014 (CT98014) is highly selective aminopyrimidine-derivatived inhibitor of GSK-3 with IC50 of 650nM and 580nM for GSK-3 and GSK-3(measured by kinase assays), respectively, and exhibits >1000-fold selectivity for GSK-3 over closely related kinases, such as cdc2. |
CSN16227 | BIO-acetoxime | 667463-85-6 | BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM. |
CSN16080 | GSK 3 Inhibitor IX | 667463-62-9 | BIO is an inhibitor of GSK-3 and CDK1–cyclinB complex. The IC50s of GSK-3αβ, CDK1, CDK5 are 5 nM, 320 nM and 83 nM, respectively. |
CSN13082 | Bikinin | 188011-69-0 | Bikinin acts as an ATP-competitive inhibitor of arabidopsis GSK-3 and effective activator of brassinosteroid (BR) signaling. |
CSN13894 | AZD2858 | 486424-20-8 | AZD2858 is an inhibitor of GSK-3 with IC50 of 68 nM that can inhibit the tau phosphorylation of S396 site and activate Wnt signaling pathway. |
CSN16226 | AZD1080 | 612487-72-6 | AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2. |
CSN15984 | AR-A014418 | 487021-52-3 | AR-A014418 is a selective inhibitor of GSK3β with IC50 of 104 ± 27 nM. |
CSN26521 | (Z)-SKI V | 927429-51-4 | and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1]. |
CSN22657 | A 1070722 | 1384424-80-9 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor with Ki of 0.6 nM for GSK-3α and GSK-3β. |
CSN27603 | 9-ING-41 | 1034895-42-5 | 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β. |
CSN23598 | 5-Bromoindole | 10075-50-0 | 5-bromoindole is an inhibitor of glycogen synthase kinase 3 (GSK-3), it can be used as important pharmaceutical chemical intermediate. |
CSN18742 | 1-Azakenpaullone | 676596-65-9 | 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, > 100-fold selectivity over CDK1/cyclin B and CDK5/p25. |
CSN78105 | ZLWH-23 | 2765251-12-3 | |
CSN84227 | ABC1183 | 1042735-18-1 |