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GSK-3
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19500 | TDZD-8 | 327036-89-5 | TDZD-8, the derivative of thiadiazolidinone, is a selective inhibitor of GSK-3. It inhibits GSK-3β with IC50 of 2 μM. |
| CSN16568 | SB-415286 | 264218-23-7 | SB-415286 is an ATP-competitive inhibitor of GSK3α/GSK3β with IC50 of 78 nM and Ki of 31 nM. |
| CSN12268 | SB-216763 | 280744-09-4 | SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP. |
| CSN22886 | Lithium Carbonate | 554-13-2 | Lithium Carbonate inhibits GSK-3 in vivo. |
| CSN11250 | Kenpaullone | 142273-20-9 | Kenpaullone is an ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 0.4 µM), CDK2/cyclin A (IC50 = 0.68 µM), CDK5/p25 (IC50 = 0.85 µM), lymphocyte kinase (IC50 = 0.47 µM) , and GSK-3β (C50 = 0.23 μM). |
| CSN11201 | Indirubin-3'-Monoxime | 160807-49-8 | Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). |
| CSN17487 | IM-12 | 1129669-05-1 | IM-12 is a GSK-3β inhibitor with IC50 of 53 nM. |
| CSN18354 | GSK-3 Inhibitor 1 | 603272-51-1 | GSK-3 inhibitor 1 is a potent GSK-3 inhibitor. |
| CSN24803 | GNF4877 | 2041073-22-5 | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively |
| CSN17624 | CP21R7 | 125314-13-8 | CP21R7 is a slective inhibitor of GSK-3β. |
| CSN13470 | CHIR-99021 | 252917-06-9 | CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, exhibiting > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
| CSN19176 | CHIR-99021 HCl | 1797989-42-4 | CHIR-99021 HCl is HCl of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM and shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. |
| CSN19149 | CHIR-99021 3HCl | 1782235-14-6 | CHIR-99021 3HCl is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, showing > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
| CSN20636 | CHIR-98024 | 556813-39-9 | CHIR-98014 is a reversible inhibitor of GSK3α and GSK3β with IC50 of 0.65 nM and 0.58 nM, respectively. |
| CSN16227 | BIO-Acetoxime | 667463-85-6 | BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM. |
| CSN16080 | BIO | 667463-62-9 | BIO is an inhibitor of GSK-3 and CDK1–cyclinB complex. The IC50s of GSK-3αβ, CDK1, CDK5 are 5 nM, 320 nM and 83 nM, respectively. |
| CSN13082 | Bikinin | 188011-69-0 | Bikinin acts as an ATP-competitive inhibitor of arabidopsis GSK-3 and effective activator of brassinosteroid (BR) signaling. |
| CSN15984 | AR-A014418 | 487021-52-3 | AR-A014418 is a selective inhibitor of GSK3β with IC50 of 104 ± 27 nM. |
| CSN26521 | (Z)-SKI V | 927429-51-4 | and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1]. |
| CSN23598 | 5-Bromoindole | 10075-50-0 | 5-bromoindole is an inhibitor of glycogen synthase kinase 3 (GSK-3), it can be used as important pharmaceutical chemical intermediate. |
| CSN18742 | 1-Azakenpaullone | 676596-65-9 | 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, > 100-fold selectivity over CDK1/cyclin B and CDK5/p25. |
