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HCV
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17404 | cis-Lomibuvir | 1026785-59-0 | VX-222 is a potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. |
CSN17357 | Velpatasvir | 1377049-84-7 | Velpatasvir is an inhibitor of hepatitis C virus nonstructural protein 5A (NS5A) (genotype 1 (GT1) to GT6 replicons). |
CSN16632 | VCH-916 | 1200133-34-1 | VCH-916 is a nonnucleoside HCV NS5B polymerase inhibitor. |
CSN12417 | Telaprevir | 402957-28-2 | Telaprevir is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease (Ki=7 nM, genotype 1a NS3-4A protease). |
CSN16292 | Tegobuvir | 1000787-75-6 | Tegobuvir is a non-nucleoside nonstructural protein (NS)5B polymerase inhibitor. |
CSN16060 | Simeprevir | 923604-59-5 | Simeprevir is an inhibitor of HCV NS3/4A protease with Ki of 0.36 nM and EC50 of 7.8 nM against viral replication. |
CSN17086 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide | 36791-04-5 | Ribavirin blocks nucleic acid synthesis and inhibits both RNA and DNA viruses. Ribavirin is a nucleoside antimetabolite antiviral agent. |
CSN16818 | Mericitabine | 940908-79-2 | R7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes. |
CSN13187 | R-1479 | 478182-28-4 | R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). |
CSN17374 | PSI-7976 | 1190308-01-0 | PSI-7976, the isomer of PSI-7977, is an inhibitor of HCV RNA replication in the HCV replicon assay (EC50=1.07 μM). |
CSN12940 | 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 863329-66-2 | PSI-6206, the deaminated derivative of PSI-6130, is a selective inhibitor of HCV NS5B polymerase and the EC50 for inhibition of HCV replicon is > 100 μM. |
CSN13063 | PSI-6130 | 817204-33-4 | PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase. |
CSN11747 | Peretinoin | 81485-25-8 | Peretinoin, an acyclic retinoid, can alter lipid metabolism and inhibit HCV RNA amplification and virus release. |
CSN15768 | Paritaprevir | 1216941-48-8 | Paritaprevir is an inhibitor of NS3-4A serine protease that may be used for treatment of hepatitis C. |
CSN15769 | Methyl ((S)-1-((S)-2-((4-((2S,5S)-1-(4-(tert-butyl)phenyl)-5-(4-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidine-2-carboxamido)phenyl)pyrrolidin-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate | 1258226-87-7 | Ombitasvir is inhibitor of hepatitis C virus protein NS5A with EC50s of 0.82 pM to 19.3 pM against HCV genotypes 1 to 5. |
CSN16559 | Nesbuvir | 691852-58-1 | Nesbuvir is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. |
CSN13898 | Grazoprevir | 1350514-68-9 | MK-5172 inhibits Hepatitis C virus NS3/4a protease with Ki of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. |
CSN13833 | Ledipasvir | 1256388-51-8 | Ledipasvir is the hepatitis C virus NS5A inhibitor with EC50 of 34 pM and 4 pM against GT1a and GT1b replicon. |
CSN17900 | Ledipasvir (diacetone) | 1502655-48-2 | Ledipasvir diacetone is an inhibitor of the hepatitis C virus NS5A protein and is an experimental drug for the treatment of hepatitis C. |
CSN17341 | Ledipasvir (acetone) | 1441674-54-9 | Ledipasvir acetone is the ingredient of ledipasvir which is inhibitor of hepatitis C virus NS5A with EC50 values of 34 pM and 4 pM against GT1a and GT1b replicon. |
CSN14312 | Ladanein | 10176-71-3 | Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins. |
CSN12990 | Methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate | 1009119-64-5 | Daclatasvir is a first-in-class, highly-selective oral HCV NS5A inhibitor. |
CSN12832 | Daclatasvir 2HCl | 1009119-65-6 | Daclatasvir 2HCl is a selective HCV NS5A inhibitor with EC50 of 9 pM - 50 pM. |
CSN10665 | Clemizole HCl | 1163-36-6 | Clemizole HCl is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM. |
CSN12581 | Boceprevir | 394730-60-0 | Boceprevir is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection. |
CSN17310 | Asunaprevir | 630420-16-5 | Asunaprevir is an inhibitor of hepatitis C virus (HCV) NS3 protease. |
CSN13704 | Dasabuvir | 1132935-63-7 | ABT-333 is an inhibitor of the RNA-dependent RNA polymerase with IC50 range from 2.2 nM to 10.7 nM. |