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HDAC
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19743 | Sulforaphane Racemate | 4478-93-7 | Sulforaphane, a natural product isolated and purified from the seeds of Brassica oleracea L. var. botrytis L. with neuroprotective, anti-inflammatory and antitumor effects, inhibits TPA-induced NF-κB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKα and NAK-IKKβ. |
| CSN24467 | SIS17 | 2374313-54-7 | SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2. |
| CSN17747 | RGFP966 | 1357389-11-7 | RGFP966 is specific inhibitor of HDAC3 with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM (measured by enzymatic activity of recombinant human HDACs). |
| CSN18796 | RGFP966 Racemate | 1396841-57-8 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC. |
| CSN21402 | Pomiferin | 572-03-2 | Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM). |
| CSN18083 | Givinostat HCl | 199657-29-9 | Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
| CSN18647 | Droxinostat | 99873-43-5 | Droxinostat is an inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively. |
| CSN17366 | BRD73954 | 1440209-96-0 | BRD73954 is a selective inhibitor of HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. |
| CSN21754 | Biphenyl-4-sulfonyl Chloride | 1623-93-4 | Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation. |
| CSN17336 | Belinostat | 866323-14-0 | Belinostat is a pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. |
| CSN19745 | Apicidin | 183506-66-3 | Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells. |
| CSN27278 | ACY-775 | 1375466-18-4 | ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM. |
| CSN23643 | 4-Phenylbutanoic acid | 1821-12-1 | 4-Phenylbutanoic acid is an inhibitor of HDAC which can regulate gene transcription with anti-tumor and neuroprotective effects. |
| CSN19518 | 4-Hydroxybenzoic Acid | 99-96-7 | 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties. |
| CSN29552 | 1-Naphthohydroxamic acid | 6953-61-3 | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation. |
| CSN19744 | (R)-Sulforaphane | 142825-10-3 | (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer. |
