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HDAC

HDAC

货号 产品名 CAS号 信息
CSN20461 WT-161 1206731-57-8 WT161 selectively inhibits HDAC6 that exhibits effective anti-tumor activities in multiple myeloma.
CSN22526 Tucidinostat 1616493-44-7 Tucidinostat is an inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor with IC50s of 95, 160, 67 and 78 nM, espectively.
CSN18859 TMP195 1314891-22-9 TMP195 is an inhibitor of class IIa histone deacetylase (HDAC) with IC50 of 15 nM - 59 nM for HDAC4, 5, 7 and 9.
CSN24808 Tinostamustine HCl 1793059-58-1 Tinostamustine is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. It is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents.
CSN16416 Theophylline 58-55-9 Theophylline is a natural product present in tea and cocoa, working as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
CSN22927 TH34 2196203-96-8 TH34 is a potent HDAC6/8/10 inhibitor that induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.
CSN21182 SR-4370 1816294-67-3 SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.
CSN24467 SIS17 2374313-54-7 SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2.
CSN18796 RGFP966 Racemate 1396841-57-8 RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.
CSN18493 Resminostat 864814-88-0 Resminostat is a potent inhibitor of HDAC1/3/6 (IC50=43-72 nM) and less potent to HDAC8 with IC50 of 877 nM.
CSN22942 Remetinostat 946150-57-8 Remetinostat, also called SHP-141, is an inhibitor of HDAC with antineoplastic activity.
CSN18839 Quisinostat dihydrochloride 875320-31-3 Quisinostat 2HCl is a second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11, greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7.
CSN21402 Pomiferin 572-03-2 Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM).
CSN18939 Pimelic Diphenylamide 106 (analog) 2070015-24-4 Pimelic diphenylamide 106 Analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity. Pimelic Diphenylamide 106 is a class I HDAC inhibitor, demonstrating no activity against class II HDACs. 106 is a slow, tight-binding inhibitor of HDACs 1, 2, and 3 with preference toward HDAC3 with Ki of approximately 14 nm, 15 times lower than the Ki for HDAC1.
CSN23161 HDAC6-IN-7 956154-63-5 NCT-14b is a selective HDAC6 inhibitor. It inhibits cell growth of α-positive MCF-7 breast cancer cells treated with estrogen but not untreated cells.
CSN32427 Nanatinostat 1256448-47-1 Nanatinostat is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC).
CSN27756 MPI_5a 1259296-46-2 MPI-5a is an effective and selective inhibitor of HDAC6 with IC50 value of 36nM.
CSN22961 MC1742 1776116-74-5 MC 1742 is a potent class I and IIb HDAC inhibitor with IC50s of 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively.
CSN24175 JAK/HDAC-IN-1 2284621-75-4 JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor with improved antiproliferative and proapoptotic activities over SAHA and ruxolitinib in several hematological cell lines.
CSN18800 HPOB 1429651-50-2 HPOB is a selective inhibitor of HDAC6 with IC50 of 56 nM.
CSN21244 SKLB-23bb 1815580-06-3 HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively
CSN22299 HDAC6 Degrader 9c 2235382-05-3 HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.
CSN26516 HDAC-IN-4 1252003-13-6 HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].
CSN20245 HDAC Inhibitor C4j 2098896-13-8 HDAC inhibitor C4j is a potent HDAC inhibitor in the cellular HDAC assay, revealed remarkable chemosensitizing properties and enhanced the cisplatin sensitivity of the cisplatin-resistant head-neck cancer cell line Cal27CisR by almost sevenfold. Furthermore, 4j almost completely reversed the cisplatin resistance in Cal27CisR.
CSN20189 ACY-957 1609389-52-7 HDAC inhibitor C001 is an inhibitor of HDACs with IC50 of 4 nM (HDAC1), 15 nM (HDAC2), 114 nM (HDAC3), and can increase Gata2 expression, which may be useful in treatment of Gata2-deficiency-associated diseases, including leukemia and other blood cell disorders.
CSN51392 Elevenostat 1454902-97-6 Elevenostat is a putative specific inhibitor of HDAC11, which has been shown to deacetylate the transcription factor FoxP3 in T cells.
CSN18647 Droxinostat 99873-43-5 Droxinostat is an inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively.
CSN18556 Domatinostat 910462-43-0 Domatinostat is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
CSN18820 Crotonoside 1818-71-9 Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.
CSN20226 CM-272 1846570-31-7 CM-272 is a potent, selective and reversible dual small molecule against G9a and DNMTs activity.
CSN20614 Ivaltinostat 936221-33-9 CG200745 is a hydroxamate-based pan-histone deacetylase inhibitor.
CSN20569 BRD3308 1550053-02-5 BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs.
CSN22725 BRD 9757 1423058-85-8 BRD 9757 is a potent and selective HDAC6 inhibitor with IC50 of 30 nM.
CSN22724 BRD 4354 315698-07-8 BRD 4354 is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively.
CSN24145 BRD 4354 ditrifluoroacetate 2444837-63-0 BRD 4354 Ditrifluoroacetate is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively.
CSN21754 Biphenyl-4-sulfonyl chloride 1623-93-4 Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation.
CSN19745 Apicidin 183506-66-3 Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells.
CSN27278 ACY-775   1375466-18-4 ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.
CSN23643 4-Phenylbutyric acid 1821-12-1 4-Phenylbutanoic acid is an inhibitor of HDAC which can regulate gene transcription with anti-tumor and neuroprotective effects.
CSN19518 4-Hydroxybenzoic acid 99-96-7 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties.
CSN29552 1-Naphthohydroxamic acid 6953-61-3 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation.
CSN19744 (R)-Sulforaphane 142825-10-3 (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer.
CSN50095 Trichostatin A 122292-85-7
CSN68780 Sulforaphane 4478-93-7
CSN29070 Pivanex 122110-53-6
CSN34624 RTS-V5 2285346-31-6
CSN36392 Biotinyl tyramide 41994-02-9
CSN84963 HDAC6-IN-6 2413603-10-6
CSN85088 HDAC6-IN-5 2413603-15-1
CSN85620 AChE/HDAC-IN-1 2414053-06-6
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