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HDAC
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16416 | Theophylline | 58-55-9 | Theophylline is a natural product present in tea and cocoa, working as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. |
| CSN22927 | TH34 | 2196203-96-8 | TH34 is a potent HDAC6/8/10 inhibitor that induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. |
| CSN24467 | SIS17 | 2374313-54-7 | SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2. |
| CSN17747 | RGFP966 | 1357389-11-7 | RGFP966 is specific inhibitor of HDAC3 with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM (measured by enzymatic activity of recombinant human HDACs). |
| CSN18796 | RGFP966 Racemate | 1396841-57-8 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC. |
| CSN21402 | Pomiferin | 572-03-2 | Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM). |
| CSN32427 | Nanatinostat | 1256448-47-1 | Nanatinostat is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC). |
| CSN18647 | Droxinostat | 99873-43-5 | Droxinostat is an inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively. |
| CSN18820 | Crotonoside | 1818-71-9 | Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML. |
| CSN21754 | Biphenyl-4-sulfonyl Chloride | 1623-93-4 | Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation. |
| CSN19745 | Apicidin | 183506-66-3 | Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells. |
| CSN23643 | 4-Phenylbutanoic acid | 1821-12-1 | 4-Phenylbutanoic acid is an inhibitor of HDAC which can regulate gene transcription with anti-tumor and neuroprotective effects. |
| CSN19518 | 4-Hydroxybenzoic Acid | 99-96-7 | 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties. |
| CSN29552 | 1-Naphthohydroxamic acid | 6953-61-3 | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation. |
| CSN19744 | (R)-Sulforaphane | 142825-10-3 | (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer. |
| CSN50095 | (-)-Trichostatin | 122292-85-7 | |
| CSN29070 | (Pivaloyloxy)methyl butyrate | 122110-53-6 |
