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HDAC

HDAC

货号 产品名 CAS号 信息
CSN19743 Sulforaphane Racemate 4478-93-7 Sulforaphane, a natural product isolated and purified from the seeds of Brassica oleracea L. var. botrytis L. with neuroprotective, anti-inflammatory and antitumor effects, inhibits TPA-induced NF-κB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKα and NAK-IKKβ.
CSN24467 SIS17 2374313-54-7 SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2.
CSN17747 RGFP966 1357389-11-7 RGFP966 is specific inhibitor of HDAC3 with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM (measured by enzymatic activity of recombinant human HDACs).
CSN18796 RGFP966 Racemate 1396841-57-8 RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.
CSN21402 Pomiferin 572-03-2 Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM).
CSN18083 Givinostat HCl 199657-29-9 Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.
CSN18647 Droxinostat 99873-43-5 Droxinostat is an inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively.
CSN17366 BRD73954 1440209-96-0 BRD73954 is a selective inhibitor of HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively.
CSN21754 Biphenyl-4-sulfonyl Chloride 1623-93-4 Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation.
CSN17336 Belinostat 866323-14-0 Belinostat is a pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors.
CSN19745 Apicidin 183506-66-3 Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells.
CSN27278 ACY-775   1375466-18-4 ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.
CSN23643 4-Phenylbutanoic acid 1821-12-1 4-Phenylbutanoic acid is an inhibitor of HDAC which can regulate gene transcription with anti-tumor and neuroprotective effects.
CSN19518 4-Hydroxybenzoic Acid 99-96-7 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties.
CSN29552 1-Naphthohydroxamic acid 6953-61-3 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation.
CSN19744 (R)-Sulforaphane 142825-10-3 (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer.
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