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HDAC
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN16689 | Sodium 2-propylpentanoate | 1069-66-5 | Valproic acid sodium is a histone deacetylase (HDAC) inhibitor (IC50=10 μM in Hela cell, 24h) has an anticancer effect. |
CSN13138 | 2-Propylpentanoic acid | 99-66-1 | Valproic acid is a histone deacetylase (HDAC) inhibitor with IC50 of 10 μM in Hela cell with anticancer effect. It can be used in the treatment of epilepsy and bipolar disorder. |
CSN17250 | UF010 | 537672-41-6 | UF010 is a selective inhibitor of HDAC3, 2, 1 and 8 with IC50s of 0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM, respectively. |
CSN17162 | Tubastatin A | 1252003-15-8 | Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more). |
CSN13649 | Tubastatin A HCl | 1310693-92-5 | Tubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more). |
CSN16346 | Tubacin | 537049-40-4 | Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. |
CSN15899 | TMP269 | 1314890-29-3 | TMP269 is an inhibitor of class IIa HDAC with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. |
CSN15949 | Tasquinimod | 254964-60-8 | Tasquinimod allosterically inhibits HDAC4 signalling with antiangiogenic and antineoplastic activities. It is a quinoline-3-carboxamide linomide analogue. |
CSN13123 | Scriptaid | 287383-59-9 | Scriptaid is an inhibitor of HDAC with greater effect on acetylated H4. |
CSN13835 | Santacruzamate A | 1477949-42-0 | Santacruzamate A is an inhibitor of HDAC2 with IC50 of 119 pM. |
CSN13496 | Romidepsin | 128517-07-7 | Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. |
CSN17747 | RGFP966 | 1357389-11-7 | RGFP966 is specific inhibitor of HDAC3 with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM (measured by enzymatic activity of recombinant human HDACs). |
CSN17367 | N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide | 1215493-56-3 | RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
CSN17533 | Resminostat HCl | 1187075-34-8 | Resminostat HCl is a potent inhibitor of HDAC1/3/6 (IC50=43-72 nM) and less potent to HDAC8 with IC50 of 877 nM. |
CSN13881 | Remodelin | 949912-58-7 | Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10. |
CSN13126 | Quisinostat | 875320-29-9 | Quisinostat is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1. |
CSN15971 | Pyroxamide | 382180-17-8 | Pyroxamide is an inhibitor of histone deacetylase (HDAC) which potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. |
CSN13125 | PTACH | 848354-66-5 | PTACH is a SAHA-based inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM. |
CSN16063 | Pracinostat | 929016-96-6 | Pracinostat is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6 and has no activity against the class III isoenzyme SIRT I. |
CSN16486 | Pimelic Diphenylamide 106 | 937039-45-7 | Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively. |
CSN16819 | PCI-34051 | 950762-95-5 | PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. |
CSN15819 | Abexinostat | 783355-60-2 | PCI-24781 is a pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. |
CSN12908 | (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide | 404950-80-7 | Panobinostat is a broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. |
CSN17253 | NKL 22 | 537034-15-4 | NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM. |
CSN15915 | Nexturastat A | 1403783-31-2 | Nexturastat A is a selective inhibitor of HDAC6 with IC50 of 5 nM. |
CSN16017 | N-(2-Aminophenyl)-4-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)benzamide | 726169-73-9 | Mocetinostat is an inhibitor of HDAC1 (IC50 = 0.15 μM), HDAC2 (IC50 = 0.29 μM) and HDAC3 (IC50 = 1.66 μM). |
CSN16038 | MC1568 | 852475-26-4 | MC1568 is a selective inhibitor of class II (IIa) histone deacetylas (HDAC II) with IC50 of 220 nM. |
CSN12888 | M344 | 251456-60-7 | M344 is HDAC inhibitor with IC50 of 100 nM and can induce cell differentiation. |
CSN17824 | LMK-235 | 1418033-25-6 | LMK235 is a HDAC inhibitor of human HDAC4 and HDAC5 with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR). |
CSN16577 | Givinostat HCl monohydrate | 732302-99-7 | ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
CSN16989 | HDAC-IN-7 | 743420-02-2 | HDAC-IN-7 is an analogue of Chidamide. Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8, also inhibiting HDAC10/11 (IC50=78/432 nM) and showing no inhibition on HDAC4/5/7/9/6 (IC50> 30 μM). |
CSN17395 | HDAC-IN-3 | 1018673-42-1 | HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor. |
CSN17612 | (E)-3-(4-((E)-3-(3-Fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide | 1239610-44-6 | HDAC-IN-1 is a chemical analog of MC 1568, which is a potent and selective class IIa HDACs inhibitor. |
CSN18301 | Givinostat | 497833-27-9 | Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively. |
CSN18083 | Givinostat HCl | 199657-29-9 | Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
CSN12566 | 3,4,5-Trihydroxybenzoic acid | 149-91-7 | Gallic acid is an organic acid that found in a variety of foods and herbs with effective antioxidant activity. |
CSN16783 | Sodium hydrogen bis(2-propylpentanoate) | 76584-70-8 | Divalproex sodium is a HDAC inhibitor used in the treatment for epilepsy. |
CSN15774 | Dacinostat | 404951-53-7 | Dacinostat is a HDAC inhibitor with IC50 of 32 nM which can activate the p21 promoter. |
CSN16258 | Fimepinostat | 1339928-25-4 | CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. |
CSN13794 | Citarinostat | 1316215-12-9 | Citarinostat selectively inhibits HDAC6 with IC50 of 4 nM. It can also inhibit HDAC3 (IC50 = 76 nM). |
CSN12488 | 4-Acetamido-N-(2-aminophenyl)benzamide | 112522-64-2 | CI-994 is an inhibitor of HDAC1 with IC50 of 0.57 μM with anti-tumor effect. It can cause G1 cell cycle arrest. |
CSN13836 | CAY10603 | 1045792-66-2 | CAY10603 is a selective inhibitor of HDAC6 with IC50 of 2 pM. |
CSN17366 | BRD73954 | 1440209-96-0 | BRD73954 is a selective inhibitor of HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. |
CSN17249 | BML-210 | 537034-17-6 | BML-210 is the HDAC inhibitor, and its mechanism of action has not been characterized. |
CSN17264 | BG45 | 926259-99-6 | BG45 is a selective inhibitor for HDAC3 with IC50 of 289 nM. |
CSN17336 | (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide | 866323-14-0 | Belinostat is a pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. |
CSN13429 | AR-42 | 935881-37-1 | AR-42 is an inhibitor of HDAC with IC50 30 nM. |
CSN17328 | ACY-738 | 1375465-91-0 | ACY-738 inhibits HDAC6 with IC50 value of 1.7 nM. |
CSN13744 | Ricolinostat | 1316214-52-4 | ACY-1215 is a selective HDAC6 inhibitor with IC50 of 5 nM, being > 10-fold selective for HDAC6 than HDAC1/2/3 (IC50 = 58, 48, and 51 nM) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. |
CSN17531 | Domatinostat tosylate | 1186222-89-8 | 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes (NO HDAC8) with IC50s of 1.2/1.12/0.57 μM for HDAC1/2/3, demonstrating high selectivity over ClassIIa/IIb/III HDACs. |