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Hedgehog
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12427 | Vismodegib | 879085-55-9 | Vismodegib is an inhibitor of hedgehog pathway with IC50 of 3 nM and also inhibits P-gp (IC50 = 3.0 μM). |
| CSN18358 | Veratramine | 60-70-8 | Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells for it is an analog of cyclopamine. |
| CSN19183 | SANT-1 | 304909-07-7 | SANT-1 can directly bind to Smoothened (Smo) receptor with Kd of 1.2 nM. It also exhibits inhibition of Smo agonist effects (IC50 = 20 nM). |
| CSN17420 | RU-SKI 43 | 1043797-53-0 | RU-SKI 43 is a small molecule inhibitor of Hhat (Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. |
| CSN19164 | RU-SKI 43 hydrochloride | 1782573-67-4 | RU-SKI 43 HCl is a small molecule inhibitor of Hhat (Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. |
| CSN10046 | Mebendazole | 31431-39-7 | Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations. |
| CSN13124 | JK184 | 315703-52-7 | JK184 is a hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. |
| CSN20410 | Hedgehog Inhibitor C15h | 1616368-12-7 | Hedgehog inhibitor C15h displays a potent hedgehog-inhibitory activity with an IC50 of 0.050 nM. |
| CSN26661 | Glabrescione B | 65893-94-9 | Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2]. |
| CSN19162 | Ciliobrevin A | 302803-72-1 | Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM. |
| CSN22696 | AY 9944 | 366-93-8 | AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling. |
| CSN25227 | 20(S)-Hydroxycholesterol | 516-72-3 | 20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells. |
