Hedgehog | GPCR/G Protein|Stem Cells/Wnt| CSNpharm

Hedgehog

Hedgehog
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货号	产品名	CAS号	信息
CSN18358	Veratramine	60-70-8	Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells for it is an analog of cyclopamine.
CSN19183	SANT-1	304909-07-7	SANT-1 can directly bind to Smoothened (Smo) receptor with Kd of 1.2 nM. It also exhibits inhibition of Smo agonist effects (IC50 = 20 nM).
CSN10046	Mebendazole	31431-39-7	Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations.
CSN13124	JK184	315703-52-7	JK184 is a hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.
CSN19162	Ciliobrevin A	302803-72-1	Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM.
CSN22696	AY 9944 2HCl	366-93-8	AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling.
CSN25227	20(S)-Hydroxycholesterol	516-72-3	20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells.