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Hedgehog
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18358 | Veratramine | 60-70-8 | Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells for it is an analog of cyclopamine. |
| CSN19183 | SANT-1 | 304909-07-7 | SANT-1 can directly bind to Smoothened (Smo) receptor with Kd of 1.2 nM. It also exhibits inhibition of Smo agonist effects (IC50 = 20 nM). |
| CSN10046 | Mebendazole | 31431-39-7 | Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations. |
| CSN13124 | JK184 | 315703-52-7 | JK184 is a hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. |
| CSN19162 | Ciliobrevin A | 302803-72-1 | Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM. |
| CSN25227 | 20(S)-Hydroxycholesterol | 516-72-3 | 20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells. |