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Histamine Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25848 | Zolantidine dimaleate | 104076-39-3 | Zolantidine dimaleate is a selective and brain penetrating H2 receptor antagonist. |
| CSN25862 | VUF 8430 dihydrobromide | 100130-32-3 | VUF 8430 dihydrobromide is a full agonist of histamine H4 receptor with pKi of 7.5 and pEC50 of 7.3. |
| CSN21872 | Triprolidine HCl | 6138-79-0 | Triprolidine Hydrochloride is the first generation histamine H1 antagonist used in allergic rhinitis. |
| CSN25841 | Trans-Triprolidine HCl | 550-70-9 | Trans-Triprolidine hydrochloride is a potent H1 receptor antagonist. |
| CSN25844 | Tiotidine | 69014-14-8 | Tiotidine is antagonist of histamine H2-receptor with negligible activity against H1- and H3- receptors. |
| CSN26513 | SUN-1334H (HCl) | 607736-84-5 | SUN-1334H is a histamine H1 receptor antagonist potentially for the treatment of allergic conjunctivitis and allergic rhinitis |
| CSN21826 | Rocastine | 91833-77-1 | Rocastine is a selective antagonist of nonsedative H1 antagonist for antihistamines. |
| CSN26180 | PU-02 | 313984-77-9 | PU-02 is an antagonist of serotonin (5-HT) receptor subtype 5-HT3. |
| CSN17113 | Promethazine HCl | 58-33-3 | Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor. |
| CSN25855 | Nα-Methylhistamine 2HCl | 16503-22-3 | Nα-Methylhistamine dihydrochloride is H2R agonist that acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and it dose dependently stimulated cAMP productions in CHO-H2R cells. |
| CSN11591 | Nylidrin HCl | 849-55-8 | Nylidrin HCl was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices. |
| CSN21744 | Niperotidine | 84845-75-0 | Niperotidine is an antagonist of histamine H2-receptor. |
| CSN11531 | Nedocromil | 69049-73-6 | Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma. |
| CSN14575 | Marmin | 14957-38-1 | Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro. |
| CSN25851 | Impentamine dihydrobromide | 149629-70-9 | Impentamine dihydrobromide is highly selective antagonist of histamine H3 receptor with pA2 of 8.4. |
| CSN25847 | Ici162,846 | 84545-30-2 | ICI 162,846 is a potent histamine H2 receptor antagonist. |
| CSN25852 | GT 2016 | 152241-24-2 | GT 2016 is a high affinity antagonist of H3 receptor with Ki of 43.8 nM. |
| CSN22023 | FRG8701 | 108498-50-6 | FRG-8701 is a new Histamine H2-receptor antagonist with IC50 of ranging from 0.25 to 0.43 μM. |
| CSN21734 | FPL59360 | 85118-44-1 | FPL59360, a anti-asthmatic compound, is histamine I receptor antagonist that prevents exercise-induced asthma. |
| CSN24500 | Emedastine | 87233-61-2 | Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (Ki = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM). |
| CSN25845 | Dimaprit 2HCl | 23256-33-9 | Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration. |
| CSN22139 | Cipralisant | 213027-19-1 | Cipralisant is a potent and selective histamine H3 receptor antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor; Cipralisant has entered in clinical trials for the treatment of attention-deficit hyperactivity disorder. |
| CSN26664 | Cimetidine sulfoxide | 54237-72-8 | Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1]. |
| CSN26201 | Chloropyramine HCl | 6170-42-9 | Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer. |
| CSN25269 | Bromazine HCl | 1808-12-4 | Bromazine hydrochloride is an antagonist of histamine H1 receptor. |
| CSN22167 | BMY-25271 | 78441-82-4 | BMY-25271 is a histamine H2 receptor antagonist. |
| CSN25225 | Betahistine | 5638-76-6 | Betahistine is a histamine analog and H1 receptor agonist. |
| CSN24137 | Bepotastine | 125602-71-3 | Bepotastine is a non-sedating and selective antagonist of the histamine 1 (H1) receptor. |
| CSN24556 | AR-R 17779 hydrochloride | 178419-42-6 | AR-R 17779 hydrochloride is a selective alpha7 nicotinic agonist with Ki value of 190 nM for rat. |
| CSN22242 | Antihistamine-1 | 1186430-60-3 | Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. |
| CSN25846 | Amthamine dihydrobromide | 142457-00-9 | Amthamine dihydrobromide is a highly selective agonist of H2 receptor. |
| CSN25843 | Aminopotentidine | 140873-26-3 | Aminopotentidine is antagonist of H2 with KB value of 220 nM. |
| CSN21455 | Acrivastine | 87848-99-5 | Acrivastine, an H1-receptor antagonist, is a second-generation antihistamine. |
| CSN23462 | 5-Hydroxyindole-3-acetic acid | 54-16-0 | 5-Hydroxyindole-3-acetic acid (5-HIAA), the major metabolite of serotonin, is a histamine H1 receptor antagonist and can be used to treat allergies. |
| CSN25863 | 4-Methylhistamine 2HCl | 36376-47-3 | 4-Methylhistamine dihydrochloride is a high affinity agonist of H4 receptor with Ki of 7 nM. |
| CSN25840 | 2-(Pyridin-2-yl)ethanamine dihydrochloride | 3343-39-3 | 2-Pyridylethylamine dihydrochloride is an agonist of histamine H1 receptor that produces vasoconstriction. |
| CSN24562 | (S)-(+)-Dimethindene maleate | 136152-65-3 | (S)-(+)-Dimethindene maleate is a subtype-selective M2 muscarinic receptor antagonist with pKi of 7.78 and is also a H1 histamine receptor antagonist with pKi of 7.48. |
| CSN25856 | (R)-(-)-α-Methylhistamine 2HBr | 868698-49-1 | (R)-(-)-α-Methylhistamine dihydrobromide is a very potent agonist of H3 receptor with Kd of 50.3 nM that crosses the blood-brain barrier and inhibits histamine synthesis and release at nanomolar concentrations. |
