欢迎来到CSNpharm!产品仅用于科研!

400-920-2911 sales@csnpharm.cn

0

Histone Demethylase

Histone Demethylase

货号 产品名 CAS号 信息
CSN51373 PFI-90 53995-62-3 PFI-90 is a selective inhibitor of histone demethylase (KDM3B).
CSN26407 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one 2514-30-9 PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM. PBIT also inhibits JARID1A and JARID1C with IC50 values of 6 and 4.9 μM, respectively[1].
CSN21075 NCGC00244536 2003260-55-5 NCGC00244536 is a selective inhibitor of KDM4A with IC50 of 10 nM.
CSN27531 L-2-Hydroxyglutaric acid disodium 63512-50-5 L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
CSN13708 JIB-04 199596-05-9 JIB-04 is a selective inhibitor of jumonji histone demethylase with IC50s of 230/340/855/445/435/1100, and 290 nM for JARID1A/JMJD2E/JMJD3/JMJD2A/JMJD2B/JMJD2C, and JMJD2D, respectively.
CSN12941 IOX1 5852-78-8 IOX1 is the broad-spectrum inhibitor of 2OG oxygenases and its IC50 for KDM4A/KDM3A and KDM4C/KDM6B/KDM2A/KDM4E are 0.6/0.1 μM and 0.6 μM/1.6 μM/1.8 μM/2.3 μM.
CSN19201 GSK-LSD1 2HCl 1821798-25-7 GSK-LSD1 2HCl is a selective LSD1 inhibitor with IC50 of 16 nM.
CSN19181 GSK-J4 HCl 1797983-09-5 GSK-J4 HCl is selective inhibitor of jumonji H3K27 demethylase. It can attenuate lipopolysaccharide (LPS)-induced proinflammatory cytokine production.
CSN16348 GSK-J4 1373423-53-0 GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor and attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release).
CSN19243 CPI-455 HCl 2095432-28-1 CPI-455 HCl is an inhibitor of KDM5. It can elevate global levels of H3K4 trimethylation (H3K4me3) and decrease the number of DTPs in multiple cancer cell line models.
CSN21279 AS-8351 796-42-9 AS8351 is a selective inhibitor of histone demethylase KDM5B (JARID1B) via competing for the chelated iron KDM5B needs and it can act as an iron chelator.
<< PREV 1 2 NEXT >>
联系
我们