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Histone Demethylase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN51373 | PFI-90 | 53995-62-3 | PFI-90 is a selective inhibitor of histone demethylase (KDM3B). |
| CSN26407 | 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one | 2514-30-9 | PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM. PBIT also inhibits JARID1A and JARID1C with IC50 values of 6 and 4.9 μM, respectively[1]. |
| CSN21075 | NCGC00244536 | 2003260-55-5 | NCGC00244536 is a selective inhibitor of KDM4A with IC50 of 10 nM. |
| CSN27531 | L-2-Hydroxyglutaric acid disodium | 63512-50-5 | L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. |
| CSN13708 | JIB-04 | 199596-05-9 | JIB-04 is a selective inhibitor of jumonji histone demethylase with IC50s of 230/340/855/445/435/1100, and 290 nM for JARID1A/JMJD2E/JMJD3/JMJD2A/JMJD2B/JMJD2C, and JMJD2D, respectively. |
| CSN12941 | IOX1 | 5852-78-8 | IOX1 is the broad-spectrum inhibitor of 2OG oxygenases and its IC50 for KDM4A/KDM3A and KDM4C/KDM6B/KDM2A/KDM4E are 0.6/0.1 μM and 0.6 μM/1.6 μM/1.8 μM/2.3 μM. |
| CSN19201 | GSK-LSD1 2HCl | 1821798-25-7 | GSK-LSD1 2HCl is a selective LSD1 inhibitor with IC50 of 16 nM. |
| CSN19181 | GSK-J4 HCl | 1797983-09-5 | GSK-J4 HCl is selective inhibitor of jumonji H3K27 demethylase. It can attenuate lipopolysaccharide (LPS)-induced proinflammatory cytokine production. |
| CSN16348 | GSK-J4 | 1373423-53-0 | GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor and attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). |
| CSN10740 | Daminozide | 1596-84-5 | Daminozide is a histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM). |
| CSN19243 | CPI-455 HCl | 2095432-28-1 | CPI-455 HCl is an inhibitor of KDM5. It can elevate global levels of H3K4 trimethylation (H3K4me3) and decrease the number of DTPs in multiple cancer cell line models. |
| CSN21279 | AS-8351 | 796-42-9 | AS8351 is a selective inhibitor of histone demethylase KDM5B (JARID1B) via competing for the chelated iron KDM5B needs and it can act as an iron chelator. |
| CSN75278 | 8-Hydroxyquinoline-5-carboxylic acid | 5852-78-8 |
