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Histone Demethylase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17182 | OG-L002 | 1357302-64-7 | OG-L002 is a selective inhibitor of LSD1 with IC50 of 20 nM. |
| CSN13837 | ML324 | 1222800-79-4 | ML324 is an inhibitor of JMJD2 demethylase with IC50 of 920 nM with antiviral activity. |
| CSN27531 | L-2-Hydroxyglutaric acid disodium | 63512-50-5 | L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. |
| CSN13708 | JIB-04 | 199596-05-9 | JIB-04 is a selective inhibitor of jumonji histone demethylase with IC50s of 230/340/855/445/435/1100, and 290 nM for JARID1A/JMJD2E/JMJD3/JMJD2A/JMJD2B/JMJD2C, and JMJD2D, respectively. |
| CSN12941 | IOX1 | 5852-78-8 | IOX1 is the broad-spectrum inhibitor of 2OG oxygenases and its IC50 for KDM4A/KDM3A and KDM4C/KDM6B/KDM2A/KDM4E are 0.6/0.1 μM and 0.6 μM/1.6 μM/1.8 μM/2.3 μM. |
| CSN19201 | GSK-LSD1 2HCl | 1821798-25-7 | GSK-LSD1 2HCl is a selective LSD1 inhibitor with IC50 of 16 nM. |
| CSN19181 | GSK-J4 HCl | 1797983-09-5 | GSK-J4 HCl is selective inhibitor of jumonji H3K27 demethylase. It can attenuate lipopolysaccharide (LPS)-induced proinflammatory cytokine production. |
| CSN13832 | GSK-J1 | 1373422-53-7 | GSK-J1 is a H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM for JMJD3 (KDM6B) and UTX (KDM6A), respectively. |
| CSN19243 | CPI-455 HCl | 2095432-28-1 | CPI-455 HCl is an inhibitor of KDM5. It can elevate global levels of H3K4 trimethylation (H3K4me3) and decrease the number of DTPs in multiple cancer cell line models. |
| CSN21279 | AS-8351 | 796-42-9 | AS8351 is a selective inhibitor of histone demethylase KDM5B (JARID1B) via competing for the chelated iron KDM5B needs and it can act as an iron chelator. |
