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Histone Methyltransferase
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN13507 | Menin-MLL inhibitor MI-2 | 1271738-62-5 | MI-2 can inhibits menin-MLL interaction with IC50 of 446 ± 28 nM. |
CSN13635 | GSK126 | 1346574-57-9 | GSK126 is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, > 1000-fold selective for EZH2 over 20 other human methyltransferases. |
CSN13673 | EPZ004777 | 1338466-77-5 | EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates > 1,200-fold selectivity for DOT1L over all other tested PMTs. |
CSN13684 | EPZ004777 HCl | 1380316-03-9 | EPZ004777 HCl is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM in a cell-free assay. |
CSN13909 | N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide | 1403254-99-8 | EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity with Ki value of 2.5±0.5 nM. |
CSN12593 | C-7280948 | 587850-67-7 | C-7280948 is an inhibitor of PRMT1. |
CSN18961 | BRD9539 | 1374601-41-8 | BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50. |
CSN13838 | BRD4770 | 1374601-40-7 | BRD4770 is an inhibitor of histone methyltransferase G9a with IC50 of 6.3 μM and it can induce cell senescence. |
CSN22360 | BIX-01338 hydrate | 1228184-65-3 | BIX-01338 hydrate is a histone lysine methyltransferase inhibitor. |
CSN13910 | Amodiaquine 2HCl Dihydrate | 6398-98-7 | Amodiaquine 2HCl is an inhibitor of histamine N-methyltransferase inhibitor with antimalarial and anti-inflammatory activities. |
CSN12600 | AMI-1 | 20324-87-2 | AMI-1 is an inhibitor of protein arginine N-methyltransferases (PRMTs) with IC50 of 8.8 μM for PRMT1 via blocking peptide-substrate binding. |
CSN13890 | 3-Deazaneplanocin A HCl | 120964-45-6 | 3-Deazaneplanocin A HCl is a cyclopentanyl analog of 3-deazaadenosine that potently interferes with SAH, a component of the methionine cycle, which causes cellular SAH levels to increase, thus repressing the activity of S-adenosyl-l-methionine–dependent histone lysine methyltransferase activity. |