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HMGCR

HMGCR

货号 产品名 CAS号 信息
CSN19944 Swertiamarin 17388-39-5 Swertiamarine is a naturally occuring secoiridoid glycoside which could inhibit HMG-CoA reductase activity.
CSN19036 SR12813 126411-39-0 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
CSN11928 Simvastatin acid ammonium 139893-43-9 Simvastatin ammonium is an HMG-CoA reductase inhibitor.
CSN11927 Simvastatin 79902-63-9 Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia.
CSN11865 Rosuvastatin 287714-41-4 Rosuvastatin is a synthetic and highly effective statin-class HMG-CoA reductase inhibitor with IC50 of 11 nM.
CSN12558 Rosuvastatin Calcium 147098-20-2 Rosuvastatin Calcium is a competitive and synthetic HMG-CoA reductase inhibitor with IC50 value of 11 nM.
CSN12298 Pravastatin sodium 81131-70-6 Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 5.6 μM.
CSN12933 Pravastatin 81093-37-0 Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
CSN11236 Pitavastatin 147511-69-1 Pitavastatin is a potent HMG-CoA reductase inhibitor and inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in a human liver cancer cell line (HepG2).
CSN11738 Pitavastatin Calcium 147526-32-7 Pitavastatin Calcium is a potent and competitive inhibitor of HMG-CoA reductase with Ki value of 1.7nM, which can block cholesterol synthesis.
CSN22122 Monacolin J 79952-42-4 Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
CSN11434 Mevastatin 73573-88-3 Mevastatin is the first discovered statin-class HMG-CoA reductase inhibitor used as a cholesterol-lowering agent isolated from Penicillium citinium.
CSN19379 Meglutol 503-49-1 Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
CSN11335 Lovastatin 75330-75-5 Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite.
CSN13091 Fluvastatin sodium 93957-55-2 Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM.
CSN12947 Fluvastatin 93957-54-1 Fluvastatin inhibits HMG-CoA reductase activity with IC50 of 8 nM.
CSN10667 Clinofibrate 30299-08-2 Clinofibrate is a HMG-CoA reductase inhibitor with IC50 value of 470 μM which can reduce plasma cholesterol levels and shows antihyperlipidemic effects.
CSN26676 Cerivastatin sodium 143201-11-0 Cerivastatin, also known as BAY-w-6228, and Rivastatin, is a statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s. Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis. During postmarketing surveillance, 52 deaths were reported in patients using Cerivastatin, mainly from rhabdomyolysis and its resultant renal failure.
CSN15642 β-Amyrin acetate 1616-93-9 beta-Amyrin acetrate, a natural cannabinoid receptor isolated and purified from the herbs of Alstonia boone, shows significant HMG-CoA-reductase and sEH inhibitory activities.
CSN27522 Atorvastatin lactone 125995-03-1 Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
CSN12529 Atorvastatin 134523-00-5 Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.
CSN12530 Atorvastatin hemicalcium salt 134523-03-8 Atorvastatin Hemicalcium is a potent HMG-CoA reductase inhibitor with IC50 value of 8 nM.
CSN11493 alpha-Asarone 2883-98-9 alpha-Asarone is a naturally occuring inhibitor of both HMG-CoA reductase (IC50 = 3 mM) and certain isoforms of the cytochrome P450 superfamily of enzymes (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively), with neuroprotective, anti-oxidative, anticonvulsive and cognitive enhancing action.
CSN29521 (3S,5R)-Fluvastatin sodium 94061-81-1 (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
CSN75676 S-2E 155730-92-0
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