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HSP
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN27850 | YUM70 | 423145-35-1 | YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. |
CSN18335 | VER-49009 | 558640-51-0 | VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. |
CSN20344 | TRC051384 HCl | 1333327-56-2 | TRC051384 is an inducer of heat shock protein Hsp70. it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. |
CSN20345 | TRC051384 | 867164-40-7 | TRC051384 is a inducer of Hsp70. |
CSN22232 | Pimitespib | 1260533-36-5 | TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively. |
CSN18482 | Retaspimycin Hydrochloride | 857402-63-2 | Retaspimycin HCl is the HCl salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. |
CSN18943 | PU-H 71 HCl | 2095432-24-7 | PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM. |
CSN17514 | PF-04929113 Mesylate | 1173111-67-5 | PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM. |
CSN32496 | PEN-866 | 1472614-83-7 | PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor. |
CSN12794 | Palmitic acid | 57-10-3 | Palmitic acid, a natural product isolated and purified from the herbs of Atractylodes macrocephala Koidz., induces down-regulation of APOM expression and anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism. Palmitic acid has a significant impact on proliferation and differentiation of NSCs in vitro and may be useful for elucidating the role of SFAs in regulating NSCs fate in physiological and pathological settings.Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. |
CSN32424 | (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone (S)-2-hydroxypropanoate | 1019889-35-0 | Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor. |
CSN26243 | Nonactin | 6833-84-7 | Nonactin is a cyclic ionophore and part of the macrotetrolide antibiotics family that selectively binds K+ and NH4+. When exposed to erythrocytes, it causes erythrocyte shrinkage and subsequent erythrocyte membrane scrambling. |
CSN17387 | ML346 | 100872-83-1 | ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay. |
CSN21425 | MKT-077 | 147366-41-4 | MKT-077 (FJ-776) is a water-soluble rhodacyanine dye with antitumor activity. It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53. |
CSN22959 | Macbecin | 73341-72-7 | Macbecin I is a Hsp90 inhibitor with IC50 of 2 μM. |
CSN18942 | KRIBB11 | 342639-96-7 | KRIBB11 is an inhibitor of heat shock factor (HSF) inhibitor, with IC50 of 1.2 μM. |
CSN17321 | KNK437 | 218924-25-5 | KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. |
CSN22600 | JG-98 | 1456551-16-8 | JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. |
CSN32437 | Icapamespib | 1000999-96-1 | Icapamespib is a heat shock protein 90 (HSP90) inhibitor. |
CSN26677 | HM03 | 500565-15-1 | HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1]. |
CSN19076 | HA15 | 1609402-14-3 | HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. |
CSN24783 | Grp94 Inhibitor-1 | 2234897-35-7 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. |
CSN22828 | Gedunin | 2753-30-2 | Gedunin is a Hsp90 inhibitor and exhibits anticancer and antimalarial activity. |
CSN13554 | Eupalinolide B | 877822-41-8 | Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC. |
CSN25416 | Ethoxyquin | 91-53-2 | Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90). |
CSN22799 | EC144 | 911397-80-3 | EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM. |
CSN18944 | Debio 0932 | 1061318-81-7 | Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L). |
CSN27185 | Col003 | 328565-16-8 | Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix. |
CSN19190 | CH5138303 | 959763-06-5 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
CSN22743 | CCT018159 | 171009-07-7 | CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM. |
CSN22011 | Bimoclomol | 130493-03-7 | Bimoclomol is a heat shock protein coinducer, used for treatment of cardiovascular diseases. |
CSN26678 | Arimoclomol | 289893-25-0 | Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). |
CSN18941 | Apoptozole | 1054543-47-3 | Apoptozole is an inhibitor of heat shock protein 70 (HSP70) and Hsc70. It induces caspase-dependent apoptosis. |
CSN26679 | AMP-PCP | 3469-78-1 | AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1]. |
CSN18284 | Alvespimycin hydrochloride | 467214-21-7 | Alvespimycin HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
CSN17209 | Tanespimycin | 75747-14-7 | 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
CSN27737 | HSP27 inhibitor J2 | 2133499-85-9 | |
CSN28855 | KBU2046 | 1143863-69-7 | |
CSN33105 | DDO-5936 | 2355377-13-6 | |
CSN40473 | Herbimycin A | 70563-58-5 | |
CSN41771 | AMP-PCP disodium | 7414-56-4 | |
CSN42078 | Conglobatin | 72263-05-9 | |
CSN50103 | KU-32 | 956498-70-7 | |
CSN50284 | Cemdomespib | 1450642-92-8 | |
CSN73281 | SNX-0723 | 1073969-18-2 | |
CSN104139 | (5-(4-Fluorobenzyl)-2,4-dihydroxyphenyl)(isoindolin-2-yl)methanone | 2134571-29-0 | |
CSN106186 | 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine xhydrate | 1202865-65-3 | |
CSN106195 | 9-Butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine | 352519-21-2 |