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HSP

HSP

货号 产品名 CAS号 信息
CSN27850 YUM70   423145-35-1 YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.
CSN18335 VER-49009 558640-51-0 VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.
CSN20344 TRC051384 HCl 1333327-56-2 TRC051384 is an inducer of heat shock protein Hsp70. it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity.
CSN20345 TRC051384 867164-40-7 TRC051384 is a inducer of Hsp70.
CSN22232 Pimitespib 1260533-36-5 TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.
CSN18482 Retaspimycin Hydrochloride 857402-63-2 Retaspimycin HCl is the HCl salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities.
CSN18943 PU-H 71 HCl 2095432-24-7 PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM.
CSN17514 PF-04929113 Mesylate 1173111-67-5 PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM.
CSN32496 PEN-866 1472614-83-7 PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor.
CSN12794 Palmitic acid 57-10-3 Palmitic acid, a natural product isolated and purified from the herbs of Atractylodes macrocephala Koidz., induces down-regulation of APOM expression and anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism. Palmitic acid has a significant impact on proliferation and differentiation of NSCs in vitro and may be useful for elucidating the role of SFAs in regulating NSCs fate in physiological and pathological settings.Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
CSN32424 Onalespib lactate 1019889-35-0 Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor.
CSN26243 Nonactin 6833-84-7 Nonactin is a cyclic ionophore and part of the macrotetrolide antibiotics family that selectively binds K+ and NH4+. When exposed to erythrocytes, it causes erythrocyte shrinkage and subsequent erythrocyte membrane scrambling.
CSN17387 ML346 100872-83-1 ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
CSN21425 MKT-077 147366-41-4 MKT-077 (FJ-776) is a water-soluble rhodacyanine dye with antitumor activity. It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53.
CSN22959 Macbecin 73341-72-7 Macbecin I is a Hsp90 inhibitor with IC50 of 2 μM.
CSN18942 KRIBB11 342639-96-7 KRIBB11 is an inhibitor of heat shock factor (HSF) inhibitor, with IC50 of 1.2 μM.
CSN17321 KNK437 218924-25-5 KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
CSN22600 JG-98 1456551-16-8 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
CSN32437 Icapamespib 1000999-96-1 Icapamespib is a heat shock protein 90 (HSP90) inhibitor.
CSN26677 HM03 500565-15-1 HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].
CSN19076 HA15 1609402-14-3 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
CSN24783 Grp94 Inhibitor-1   2234897-35-7 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1].
CSN22828 Gedunin 2753-30-2 Gedunin is a Hsp90 inhibitor and exhibits anticancer and antimalarial activity.
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN25416 Ethoxyquin 91-53-2 Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).
CSN22799 EC144 911397-80-3 EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM.
CSN18944 Debio 0932 1061318-81-7 Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).
CSN27185 Col003   328565-16-8 Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix.
CSN19190 CH5138303 959763-06-5 CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
CSN22743 CCT018159 171009-07-7 CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM.
CSN22011 Bimoclomol 130493-03-7 Bimoclomol is a heat shock protein coinducer, used for treatment of cardiovascular diseases.
CSN26678 Arimoclomol 289893-25-0 Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP).
CSN18941 Apoptozole 1054543-47-3 Apoptozole is an inhibitor of heat shock protein 70 (HSP70) and Hsc70. It induces caspase-dependent apoptosis.
CSN26679 AMP-PCP 3469-78-1 AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].
CSN18284 Alvespimycin hydrochloride 467214-21-7 Alvespimycin HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.
CSN17209 Tanespimycin 75747-14-7 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
CSN27737 HSP27 inhibitor J2 2133499-85-9
CSN28855 KBU2046 1143863-69-7
CSN33105 DDO-5936 2355377-13-6
CSN40473 Herbimycin A 70563-58-5
CSN41771 AMP-PCP disodium 7414-56-4
CSN42078 Conglobatin 72263-05-9
CSN50103 KU-32 956498-70-7
CSN50284 Cemdomespib 1450642-92-8
CSN73281 SNX-0723 1073969-18-2
CSN104139 (5-(4-Fluorobenzyl)-2,4-dihydroxyphenyl)(isoindolin-2-yl)methanone 2134571-29-0
CSN106186 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine xhydrate 1202865-65-3
CSN106195 9-Butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine 352519-21-2
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