欢迎来到CSNpharm!产品仅用于科研!

400-920-2911 sales@csnpharm.cn

0

Inflammation/Immunology

货号 产品名 CAS号 信息
CSN19878 20(R)-Ginsenoside Rh2 112246-15-8 20(R)-Ginsenoside Rh2 has anticancer effects and can increase inchoate apoptotic rate, reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells. It is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey..
CSN19682 GSK2982772 1622848-92-3 GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.
CSN19926 Irigenin 548-76-5 Irigenin is a naturally occuring O-methylated isoflavone.
CSN20178 Mogroside III-E 88901-37-5 Mogroside IIIE a naturally occuring cucurbitane glycoside which can attenuate gestational diabetes mellitus through activating of AMPK signaling pathway in mice.
CSN20186 PRT-060318 1194961-19-7 PRT-060318 is an inhibitor of Syk with IC50 of 4 nM. It is used to treat heparin-induced thrombocytopenia (HIT).
CSN20354 SC-560 188817-13-2 SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo.
CSN20447 VUF10460 1028327-66-3 VUF 10460 is a selective agonist of histamine H4 receptor with pKi of 8.22.
CSN20518 KIN1148 1428729-56-9 KIN1148 is an IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.
CSN20371 Docosahexaenoic Acid 6217-54-5 Docosahexaenoic acid, an endogenous omega-3 fatty acid, acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR).
CSN20408 LY2955303 1433497-19-8 LY2955303 is a selective antagonist of RAR-gamma with Ki of 1.09 nM that used to treatm osteoarthritis pain.
CSN20384 Mofezolac 78967-07-4 Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation.
CSN19948 Roburic acid 6812-81-3 Roburic acid, a natural product isolated and purified from the roots of Gentiana macrophylla, inhibits COX-1 and COX-2.
CSN20259 CU-CPT17e 2109805-75-4 CU-CPT17e is a multi-Toll-like receptor (TLR3/8/9) agonist with proinflammatory and anticancer activities.
CSN19864 C16-PAF 74389-68-7 PAF (C16) is an endogenous platelet-activating factor (PAF) and ligand for PAF receptors.
CSN19826 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile 906673-33-4 AN-2898 is a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection.
CSN20272 27-Hydroxycholesterol 20380-11-4 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
CSN20407 TLR7 agonist 2 1642857-69-9 TLR7 agonist C54 is a potent and selective TLR7 agonist which effectively induces a transient interferon stimulated gene (ISG) response in mice and cynomolgus monkeys, and demonstrates th potential for the immunotherapy of hepatitis B virus.
CSN19767 BMS-935177 1231889-53-4 BMS-935177 is a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases.
CSN19738 Seletalisib 1362850-20-1 Seletalisib is a potent and selective PI3 kinase inhibitor, which may be useful for the treatment of immune-inflammatory diseases, such as psoriasis amd primary Sjogren's syndrome.
CSN20270 G2013 1986-15-8 G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells.
CSN20405 IMM-H004 1456807-80-9 IMM-H004 is a potent inhibitor of BV2 microglia activation, protecting PC12 cells and primary neurons against indirect toxicity mediated by exposure to conditioned medium (CM) from LPS-treated BV2 cells.
CSN20435 GPR4 antagonist 1 1197879-16-5 GPR4 antagonist C39c shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain.
CSN19750 Telratolimod 1359993-59-1 MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors.
CSN19735 RP-001 HCl 1781880-34-9 RP001 is a sphingosine-1-phosphate receptor 1 agonist which inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung.
CSN19685 PF-00956980 1262832-74-5 PF-956980 is a FGF1 receptor antagonist, a PDGF receptor modulator, an Flt3 tyrosine kinase modulator, and a VEGF antagonist used as immunosuppressive agent.
CSN19687 PF-06263276 1421502-62-6 PF-06263276 is a potent and selective pan-JAK inhibitor which is suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
CSN20369 PHD-1 Inhibitor C53 2009345-20-2 PHD-1 inhibitor C53 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and B/P 0.21).
CSN20370 PHD-1 Inhibitor C54 2009344-53-8 PHD-1 inhibitor C54 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and B/P 0.03).
CSN20170 Mitochonic acid 35 1611470-23-5 MA-35 is an indole compound attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways.
CSN20419 GSK-2245035 maleate 1325212-97-2 GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity.
CSN20511 Vitacoxib 1374128-90-1 Vitacoxib is an imidazole derivative and a COX-2 selective inhibitor to be marketed for veterinary use as nonsteroidal anti-inflammatory drugs.
CSN20367 PHD-1-IN-1 2009343-14-8 PHD-1 inhibitor C17 is an early lead compound of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
CSN20267 JAK Inhibitor C35 1400687-19-5 JAK inhibitor C6 is a potent dual JAK1/3 inhibitor providing exceptional biochemical potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2.
CSN20368 PHD-1 Inhibitor C39 2009343-19-3 PHD-1 inhibitor C39 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability.
CSN20526 U-74389G 153190-29-5 U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.
CSN20258 PI3Kδ-IN-1 1911564-39-0 PI3Kδ inhibitor C52 is a potent, selective, and efficacious PI3Kδ inhibitor with improved Caco-2 permeability, reduced Caco-2 efflux, reduced hERG PC activity, and increased selectivity profile while maintaining potency in the CD69 hWB assay, and is very potent in PK/PD assays and highly efficacious in a mouse collagen-induced arthritis model.
CSN20296 Poseltinib 1353552-97-2 Poseltinib is a tyrosine kinase inhibitor of Bruton's tyrosine kinase (BTK).
CSN20297 BMS-986142 1643368-58-4 BMS-986142 is a potent, selective, reversible BTK inhibitor. BMS-986142 shows BTK IC50 = 0.5nM and human WB IC50 = 90 nM.
CSN20329 Imrecoxib 395683-14-4 Imrecoxib is a selective COX-2 inhibitor.
CSN20320 Hjp272 1072467-37-8 HJP272, an endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury.
CSN20299 Cbs-3595 452056-93-8 CBS-3595 is a dual p38α MAPK/PDE-4 inhibitor with activity against TNFα -related diseases.
CSN20312 Rimacalib 215174-50-8 SMP-114 is a CaMKII inhibitor with oral bioavailability and mediates the reduction SR Ca(2+) leak and arrhythmogenic cellular correlates.
CSN20279 Tanimilast 1239278-59-1 CHF-6001 is a PDE4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration.
CSN20301 ADAMTS Inhibitor C7 1607004-34-1 ADAMTS inhibitor C7 is an inhibitor of aggrecanase 1 and 2 (ADAMTS-4 and ADAMTS-5) had good oral pharmacokinetics in rats and showed efficacy in a rat chemical model of os-teoarthritis.
CSN20290 Roflupram 1093412-18-0 Roflupram is a phosphodiesterase 4 inhibitior which suppresses inflammasome activation through autophagy in microglial cells.
CSN20542 1-((3aR,12aR)-2-((4-Chlorophenyl)sulfonyl)-5-((R)-1-hydroxypropan-2-yl)-6-oxo-2,3,3a,4,5,6,7,12a-octahydro-1H-benzo[h]pyrrolo[3,4-b][1,5]oxazonin-9-yl)-3-(4-(trifluoromethyl)phenyl)urea 2174006-13-2 BRD70326 potentiates IL-10 production by suppressing microtubule polmerization.
CSN20540 BRD6989 642008-81-9 BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity.
<< PREV 1 2 3 4 5 6 7 8 9 NEXT >>
联系
我们