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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN19878 | 20(R)-Ginsenoside Rh2 | 112246-15-8 | 20(R)-Ginsenoside Rh2 has anticancer effects and can increase inchoate apoptotic rate, reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells. It is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey.. |
CSN19682 | GSK2982772 | 1622848-92-3 | GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases. |
CSN19926 | Irigenin | 548-76-5 | Irigenin is a naturally occuring O-methylated isoflavone. |
CSN20178 | Mogroside III-E | 88901-37-5 | Mogroside IIIE a naturally occuring cucurbitane glycoside which can attenuate gestational diabetes mellitus through activating of AMPK signaling pathway in mice. |
CSN20186 | PRT-060318 | 1194961-19-7 | PRT-060318 is an inhibitor of Syk with IC50 of 4 nM. It is used to treat heparin-induced thrombocytopenia (HIT). |
CSN20354 | SC-560 | 188817-13-2 | SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo. |
CSN20447 | VUF10460 | 1028327-66-3 | VUF 10460 is a selective agonist of histamine H4 receptor with pKi of 8.22. |
CSN20518 | KIN1148 | 1428729-56-9 | KIN1148 is an IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response. |
CSN20371 | Docosahexaenoic Acid | 6217-54-5 | Docosahexaenoic acid, an endogenous omega-3 fatty acid, acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). |
CSN20408 | LY2955303 | 1433497-19-8 | LY2955303 is a selective antagonist of RAR-gamma with Ki of 1.09 nM that used to treatm osteoarthritis pain. |
CSN20384 | Mofezolac | 78967-07-4 | Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation. |
CSN19948 | Roburic acid | 6812-81-3 | Roburic acid, a natural product isolated and purified from the roots of Gentiana macrophylla, inhibits COX-1 and COX-2. |
CSN20259 | CU-CPT17e | 2109805-75-4 | CU-CPT17e is a multi-Toll-like receptor (TLR3/8/9) agonist with proinflammatory and anticancer activities. |
CSN19864 | C16-PAF | 74389-68-7 | PAF (C16) is an endogenous platelet-activating factor (PAF) and ligand for PAF receptors. |
CSN19826 | 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile | 906673-33-4 | AN-2898 is a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection. |
CSN20272 | 27-Hydroxycholesterol | 20380-11-4 | 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1. |
CSN20407 | TLR7 agonist 2 | 1642857-69-9 | TLR7 agonist C54 is a potent and selective TLR7 agonist which effectively induces a transient interferon stimulated gene (ISG) response in mice and cynomolgus monkeys, and demonstrates th potential for the immunotherapy of hepatitis B virus. |
CSN19767 | BMS-935177 | 1231889-53-4 | BMS-935177 is a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases. |
CSN19738 | Seletalisib | 1362850-20-1 | Seletalisib is a potent and selective PI3 kinase inhibitor, which may be useful for the treatment of immune-inflammatory diseases, such as psoriasis amd primary Sjogren's syndrome. |
CSN20270 | G2013 | 1986-15-8 | G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells. |
CSN20405 | IMM-H004 | 1456807-80-9 | IMM-H004 is a potent inhibitor of BV2 microglia activation, protecting PC12 cells and primary neurons against indirect toxicity mediated by exposure to conditioned medium (CM) from LPS-treated BV2 cells. |
CSN20435 | GPR4 antagonist 1 | 1197879-16-5 | GPR4 antagonist C39c shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain. |
CSN19750 | Telratolimod | 1359993-59-1 | MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors. |
CSN19735 | RP-001 HCl | 1781880-34-9 | RP001 is a sphingosine-1-phosphate receptor 1 agonist which inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung. |
CSN19685 | PF-00956980 | 1262832-74-5 | PF-956980 is a FGF1 receptor antagonist, a PDGF receptor modulator, an Flt3 tyrosine kinase modulator, and a VEGF antagonist used as immunosuppressive agent. |
CSN19687 | PF-06263276 | 1421502-62-6 | PF-06263276 is a potent and selective pan-JAK inhibitor which is suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. |
CSN20369 | PHD-1 Inhibitor C53 | 2009345-20-2 | PHD-1 inhibitor C53 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and B/P 0.21). |
CSN20370 | PHD-1 Inhibitor C54 | 2009344-53-8 | PHD-1 inhibitor C54 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and B/P 0.03). |
CSN20170 | Mitochonic acid 35 | 1611470-23-5 | MA-35 is an indole compound attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways. |
CSN20419 | GSK-2245035 maleate | 1325212-97-2 | GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity. |
CSN20511 | Vitacoxib | 1374128-90-1 | Vitacoxib is an imidazole derivative and a COX-2 selective inhibitor to be marketed for veterinary use as nonsteroidal anti-inflammatory drugs. |
CSN20367 | PHD-1-IN-1 | 2009343-14-8 | PHD-1 inhibitor C17 is an early lead compound of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro. |
CSN20267 | JAK Inhibitor C35 | 1400687-19-5 | JAK inhibitor C6 is a potent dual JAK1/3 inhibitor providing exceptional biochemical potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2. |
CSN20368 | PHD-1 Inhibitor C39 | 2009343-19-3 | PHD-1 inhibitor C39 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability. |
CSN20526 | U-74389G | 153190-29-5 | U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models. |
CSN20258 | PI3Kδ-IN-1 | 1911564-39-0 | PI3Kδ inhibitor C52 is a potent, selective, and efficacious PI3Kδ inhibitor with improved Caco-2 permeability, reduced Caco-2 efflux, reduced hERG PC activity, and increased selectivity profile while maintaining potency in the CD69 hWB assay, and is very potent in PK/PD assays and highly efficacious in a mouse collagen-induced arthritis model. |
CSN20296 | Poseltinib | 1353552-97-2 | Poseltinib is a tyrosine kinase inhibitor of Bruton's tyrosine kinase (BTK). |
CSN20297 | BMS-986142 | 1643368-58-4 | BMS-986142 is a potent, selective, reversible BTK inhibitor. BMS-986142 shows BTK IC50 = 0.5nM and human WB IC50 = 90 nM. |
CSN20329 | Imrecoxib | 395683-14-4 | Imrecoxib is a selective COX-2 inhibitor. |
CSN20320 | Hjp272 | 1072467-37-8 | HJP272, an endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury. |
CSN20299 | Cbs-3595 | 452056-93-8 | CBS-3595 is a dual p38α MAPK/PDE-4 inhibitor with activity against TNFα -related diseases. |
CSN20312 | Rimacalib | 215174-50-8 | SMP-114 is a CaMKII inhibitor with oral bioavailability and mediates the reduction SR Ca(2+) leak and arrhythmogenic cellular correlates. |
CSN20279 | Tanimilast | 1239278-59-1 | CHF-6001 is a PDE4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration. |
CSN20301 | ADAMTS Inhibitor C7 | 1607004-34-1 | ADAMTS inhibitor C7 is an inhibitor of aggrecanase 1 and 2 (ADAMTS-4 and ADAMTS-5) had good oral pharmacokinetics in rats and showed efficacy in a rat chemical model of os-teoarthritis. |
CSN20290 | Roflupram | 1093412-18-0 | Roflupram is a phosphodiesterase 4 inhibitior which suppresses inflammasome activation through autophagy in microglial cells. |
CSN20542 | 1-((3aR,12aR)-2-((4-Chlorophenyl)sulfonyl)-5-((R)-1-hydroxypropan-2-yl)-6-oxo-2,3,3a,4,5,6,7,12a-octahydro-1H-benzo[h]pyrrolo[3,4-b][1,5]oxazonin-9-yl)-3-(4-(trifluoromethyl)phenyl)urea | 2174006-13-2 | BRD70326 potentiates IL-10 production by suppressing microtubule polmerization. |
CSN20540 | BRD6989 | 642008-81-9 | BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity. |