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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18721 | Upadacitinib | 1310726-60-3 | Upadacitinib is a selective JAK1 inhibitor with an IC50 of 43 nM. |
| CSN19018 | YM-58483 | 223499-30-7 | YM-58483 is a selective and potent blocker of store-operated Ca2+ entry (SOCE), which can regulate the activation of non-excitable cells such as lymphocytes. |
| CSN19077 | Leukadherin-1 | 344897-95-6 | Leukadherin-1 is allosteric activator of CD11b/CD18 with EC50 value of 4 μM for increasing CD11b/CD18-dependent cell adhesion to fibrinogen. |
| CSN19204 | Cerdulatinib HCl | 1369761-01-2 | Cerdulatinib HCl is a dual JAK/SYK inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. It also inhibits other kinases with IC50 less than 200 nM. |
| CSN19396 | (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid | 24280-93-1 | Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species. |
| CSN19403 | Ketotifen fumarate salt | 34580-14-8 | Ketotifen fumarate is a noncompetitive H1 receptor antagonist and mast cell stabilizer that is used to treat asthma. |
| CSN19464 | 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one | 489-32-7 | Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold selective for PDE5 than PDE4 and exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. It is a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum.. |
| CSN19472 | LY320135 | 176977-56-3 | LY-320135 is a potent and selective Canniboid CB1 receptor antagonist/inverse agonist. LY-320135 is selective (~70 fold) over Canniboid CB2 receptors. This compound shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM). |
| CSN19067 | 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea | 1414963-82-8 | NK-252 is a Nrf2 activator, exhibits a greater Nrf2-activating potential than OPZ. |
| CSN19298 | Fenspiride HCl | 5053-08-7 | Fenspiride HCl is an antagonist of α-adrenergic receptors and H1 histamine receptors and also inhibits phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively. |
| CSN18737 | BMS-582949 | 623152-17-0 | BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM,inhibiting both p38 kinase activity and activation of p38. |
| CSN19400 | (R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN19171 | 5-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione | 648449-76-7 | AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, showing over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and being 18-fold selective for PI3Kγ than PI3Kα. |
| CSN19459 | 7,4'-Di-O-methylapigenin | 5128-44-9 | 7,4'-Di-O-methylapigenin, a flavonoid purified from aquilaria sinensis, can inhibit α-glucosidase, α-amylase enzymes and enhance 2-NBDG uptake in L6 cells. It has hypolipidemic effect. |
| CSN19048 | Talarozole (R enantiomer) | 870093-23-5 | Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN18968 | Latrepirdine 2HCl | 97657-92-6 | Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
| CSN19134 | Chebulagic acid | 23094-71-5 | Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. |
| CSN18895 | C 87 | 1609281-56-2 | C 87 is a small-moleculeTNFα inhibitor and potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. |
| CSN19006 | ADU-S100 ammonium salt | 1638750-96-5 | ML RR-S2 CDA ammonium is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles. |
| CSN18646 | Imiquimod HCl | 99011-78-6 | Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN18849 | Acebilustat | 943764-99-6 | Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug. |
| CSN19027 | AZD9056 HCl | 345303-91-5 | AZD9056 HCl is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. |
| CSN18893 | Tosufloxacin tosylate hydrate | 1400591-39-0 | Tosufloxacin Tosylate Hydrate works as an antimicrobial agent, an antiinfective agent, a DNA synthesis inhibitor, a hepatotoxic agent and a topoisomerase IV inhibitor. |
| CSN18981 | Etrasimod | 1206123-37-6 | Etrasimod is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. |
| CSN19014 | Acumapimod | 836683-15-9 | Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |
| CSN18641 | BI605906 | 960293-88-3 | BI-605906, an inhibitor of IKKβ, inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP. |
| CSN19351 | SCH 563705 | 473728-58-4 | SCH-563705 is a potent dual CXCR2 (IC50= 1.3 nM)/CXCR1 (IC50= 7.3 nM) antagonist. |
| CSN19386 | Epinastine | 80012-43-7 | Epinastine is mast cell stabilizer and antihistamine that is used to treat allergic conjunctivitis. |
| CSN18630 | Danirixin | 954126-98-8 | Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist. |
| CSN18850 | NOD-IN-1 | 132819-92-2 | NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively. |
| CSN18980 | Piperoxan HCl | 135-87-5 | Piperoxan HCl is an α2 adrenoceptor antagonist. |
| CSN18620 | Lck inhibitor 2 | 944795-06-6 | Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively. |
| CSN18604 | Fiboflapon | 936350-00-4 | GSK2190915 is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM. |
| CSN18657 | Zimlovisertib | 1817626-54-2 | PF-06650833 is an inhibitor ofInterleukin-1 receptor associated kinase 4 (IRAK4), and used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas. |
| CSN19454 | Asiatic acid | 464-92-6 | Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, commonly used in wound healing by increasing collagen production. |
| CSN19446 | Penfluridol | 26864-56-2 | Penfluridol, a T-type calcium channel blocker, is a highly potent, first generation diphenylbutylpiperidine antipsychotic. |
| CSN18593 | IRAK inhibitor 2 | 928333-30-6 | IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor . |
| CSN18612 | Ruxolitinib (S enantiomer) | 941685-37-6 | S-Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3. |
| CSN19387 | 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione | 28822-58-4 | IBMX is a competitive nonselective PDEs inhibitor and a nonselective adenosine receptor antagonist, with IC50 of 2-50 μM but does not inhibit PDE8 or PDE9. |
| CSN19150 | RO9021 | 1446790-62-0 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. |
| CSN19224 | MRT67307 HCl | 2095432-39-4 | MRT67307 HCl is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. |
| CSN19226 | Ochromycinone | 111540-00-2 | STA-21 is a selective STAT3 inhibitor. |
| CSN19212 | Pexmetinib | 945614-12-0 | Pexmetinib is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. |
| CSN19181 | GSK-J4 HCl | 1797983-09-5 | GSK-J4 HCl is selective inhibitor of jumonji H3K27 demethylase. It can attenuate lipopolysaccharide (LPS)-induced proinflammatory cytokine production. |
| CSN19005 | IFN alpha-IFNAR-IN-1 HCl | 2070014-98-9 | IFN alpha-IFNAR-IN-1 HCl is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR and inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 μM). |
| CSN19007 | IRAK inhibitor 4 (trans) | 2070014-89-8 | IRAK inhibitor 4 trans is the trans form of IRAK inhibitor 4,which is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. |
| CSN19047 | PF-8380 HCl | 2070015-01-7 | PF-8380 HCl is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. |
| CSN19239 | trans-N-methyl-1-(4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide maleate | 1640292-55-2 | Oclacitinib Fumarate is a potent JAK inhibitor with IC50 value ranging in 10-99 nM for JAK family members, most potent against JAK1 with IC50 value of 10 nM. |
