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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17995 | Adelmidrol | 1675-66-7 | Adelmidrol is an ethanolamide derivative of azelaic acid with anti-inflammatory properties partly dependent on PPARγ, it also markedly reduce pro-inflammatory NF-κB pathway. |
CSN18163 | MCC950 sodium | 256373-96-3 | MCC950 Sodium is a potent and highly specific small molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 nM in BMDMs. |
CSN18270 | PS-1145 | 431898-65-6 | PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM. |
CSN18346 | Losmapimod | 585543-15-3 | Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
CSN18402 | Vidofludimus | 717824-30-1 | Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug. |
CSN18340 | 3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol | 575474-82-7 | R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM. |
CSN18307 | IRAK-1-4 Inhibitor I | 509093-47-4 | IRAK-1-4 Inhibitor I is a IRAK-4 inhibitor with IC50 of 200 nM. |
CSN18467 | cGAMP | 849214-04-6 | cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity. |
CSN18234 | NS6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
CSN17947 | AZD3264 | 1609281-86-8 | AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
CSN18465 | Bentamapimod | 848344-36-5 | AS-602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively. |
CSN18051 | AMD 3465 | 185991-24-6 | AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
CSN18219 | PCI 29732 | 330786-25-9 | PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. |
CSN17882 | HG-9-91-01 | 1456858-58-4 | HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. |
CSN18566 | BMS-582949 HCl | 912806-16-7 | BMS-582949 HCl is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM. |
CSN18528 | INCB 3284 | 887401-92-5 | INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM (inhibition of monocyte chemoattractant protein-1 binding to hCCR2). |
CSN18411 | BAY 61-3606 | 732983-37-8 | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
CSN17816 | GSK256066 Trifluoroacetate | 1415560-64-3 | GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7. |
CSN18104 | MCC950 | 210826-40-7 | MCC950 is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs. |
CSN17833 | GSK805 | 1426802-50-7 | RORγt-IN-1 is a potent, orally bioavailable RORγt inhibitor with pIC50 of 8.4 and > 8.2 for RORγ FRET assay and Th17 assay. |
CSN18539 | Imiquimod maleate | 896106-16-4 | Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
CSN18171 | Reparixin L-lysine salt | 266359-93-7 | Reparixin L-lysine is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models. |
CSN17912 | ML355 | 1532593-30-8 | ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 µM, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM). |
CSN18560 | Adapalene sodium salt | 911110-93-5 | Adapalene sodium is a synthetic retinoid which is a Retinoic acid receptor agonist (RAR). |
CSN18456 | IFN alpha-IFNAR-IN-1 | 844882-93-5 | IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR and inhibits MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 μM). |
CSN18135 | Lansoprazole sodium | 226904-00-3 | Lansoprazole sodium is a proton pump inhibitor which prevents the stomach from producing acid. |
CSN17892 | GSK2981278 | 1474110-21-8 | GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator. |
CSN18487 | GSK319347A | 862812-98-4 | IKK-3 inhibitor is a potent and selective inhibitor of IKK-epsilon kinase with IC50 of 40 nM and is inactive at IKK-α and IKK-β. |
CSN18182 | BX471 HCl | 288262-96-4 | BX471 HCl is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
CSN18114 | BX471 | 217645-70-0 | BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
CSN18352 | Bay 65-1942 | 600734-02-9 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase. |
CSN18083 | Givinostat HCl | 199657-29-9 | Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
CSN18477 | NBI-74330 | 855527-92-3 | NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of [(125)I]CXCL10 and [(125)I]CXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively. |
CSN18192 | RS102895 | 300815-41-2 | RS102895 is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1 (IC50 > 17 μM). |
CSN18399 | STING agonist-1 | 702662-50-8 | STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. |
CSN18274 | GW627368 | 439288-66-1 | GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor (Ki= 100 nM) with additional human TP receptor affinity (Ki= 150 nM). |
CSN18329 | PNRI-299 | 550368-41-7 | PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 μM without affecting NF-kappaB transcription (up to 200 μM) or thioredoxin (up to 200 μM). |
CSN18503 | TG 100572 HCl | 867331-64-4 | TG 100572 HCl is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. |
CSN18113 | BCX 1470 methanesulfonate | 217099-44-0 | BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
CSN18287 | AMG 487 | 473719-41-4 | AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3. |
CSN18058 | PI4KIIIbeta-IN-10 | 1881233-39-1 | PI4KIIIbeta-IN-10 is the most potent PI4KIIIβ inhibitor currently reported, with very minor off-target inhibition of PI4KIIIβ related lipid kinases (IC50 = 3.6 nM). |
CSN18112 | BCX 1470 | 217099-43-9 | BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
CSN18339 | Laropiprant | 571170-77-9 | Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM). |
CSN18397 | Vercirnon | 698394-73-9 | Vercirnon is a highly potent antagonist of CCR9, which has been implicated in the aetiology of inflammatory bowel diseases such as Crohn's disease. |
CSN18176 | SD 0006 | 271576-80-8 | SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po). |
CSN18224 | Inulicin | 33627-41-7 | 1-O-Acetylbritannilactone is a sesquiterpene isolated from the medicinal plant Inula britannica with anticancer and anti-inflammation acitvity. |
CSN18301 | Givinostat | 497833-27-9 | Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively. |
CSN18590 | Acitretin sodium | 925701-88-8 | Acitretin sodium is a second-generation, systemic retinoid and an agonist for retinoic acid receptors that has been used in the treatment of psoriasis. |