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Inflammation/Immunology

货号 产品名 CAS号 信息
CSN17334 BMS-202 1675203-84-5 PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction with IC50 of 18 nM.
CSN17758 LY 3000328 1373215-15-6 LY 3000328 is a highly selective and potent Cathepsin S inhibitor with IC50 of 7.7±5.85 nM and 1.67±1.17 nM for hCat S and mCat S respectively, can be used in treatment for abdominal aortic aneurysm.
CSN17359 AM095 free acid 1228690-36-5 AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
CSN17242 MS436 1395084-25-9 MS436, a diazobenzene-based small compound, is an inhibitor of BRD4 bromodomains with Ki values of 30-50 nM.
CSN17363 Tanzisertib 899805-25-5 CC-930 is a selective ATP-competitive JNK inhibitor with IC50 values of 61nM, 5nM and 5nM for JNK1, 2 and 3, respectively.
CSN17403 Fostamatinib Disodium 1025687-58-4 R788 disodium, the disodium form of R788, is a Syk inhibitor with IC50 of 41 nM.
CSN17535 Baricitinib phosphate 1187595-84-1 Baricitinib Phosphate can selectively inhibit JAK1/2 inhibitor with IC50 values of 5.9 nM and 5.7 nM.
CSN17716 E6446 2HCl 1345675-25-3 E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN17724 GSK583 1346547-00-9 GSK583 is a selective inhibitor of RIP2 Kinase and IC50 value is 5 nM.
CSN17806 JNK-IN-7 1408064-71-0 JNK-IN-7 is a potent inhibitor for JNK all isoforms with IC50 values of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.
CSN17808 JNK-IN-8 1410880-22-6 JNK-IN-8 is a potent, selective and irreversible JNK inhibitor with IC50 values of 4.7 nM, 18.7 nM and 1 nM for JNK1, 2 and 3, respectively.
CSN17723 JNJ-42165279 1346528-50-4 JNJ-42165279 inhibits hFAAH and rFAAH with IC50 of 70 ± 8 nM and 313 ± 28 nM respectively.
CSN17703 SR1001 1335106-03-0 SR1001 is a selective RORα and RORγ inverse agonist and inhibits TH17 cell differentiation and function.
CSN17809 TRAP-6 141136-83-6 TRAP-6 is protease-activated receptor 1 (PAR1) agonist.
CSN17567 JZL 195 1210004-12-8 JZL195 functions as a dual inhibitor of FAAH and MAGL with IC50 of 13 nM and 19 nM respectively in brain of mouse.
CSN17509 Mycophenolate mofetil hydrochloride 116680-01-4 Mycophenolate mofetil HCl, is an immunosuppressant drug used to prevent rejection in organ transplantation.
CSN17265 Setastine 64294-95-7 Setastine is an antihistamine used to treat allergies and rhinitis.
CSN17538 MRT67307 1190378-57-4 MRT67307 is a dual inhibitor of the IKKe and TBK-1.
CSN17712 N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide 1341224-83-6 PF-4136309 is a potent, Selective, and orally bioavailable CCR2 antagonist.
CSN17691 S1P1 agonist III 1324003-64-6 TC-G 1006 is a potent and orally active S1P1 agonist with EC50 of 18 nM, showing no activity on S1P3.
CSN17384 MK-2894 1006036-87-8 MK-2894 is a highly potent and selective second generation EP4 antagonist.
CSN17430 Sodium 2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoate 104931-56-8 Tranilast is an antiallergic agent.
CSN17456 Ruxolitinib sulfate 1092939-16-6 Ruxolitinib sulfate is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3.
CSN17534 AN3199 1187187-10-5 AN-3199 is a PDE4 inhibitor with IC50 of 94.5 nM.
CSN17392 IRAK inhibitor 3 1012343-93-9 IRAK inhibitor 3 is an interleukin-1 receptor associated kinase inhibitor.
CSN17640 INCB3344 1262238-11-8 INCB3344 is a potent and selective small molecule antagonist of the mouse CCR2 receptor and inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
CSN17598 CAY10650 1233706-88-1 CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM.
CSN17557 SRT3190 1204707-73-2 SRT3190 is CXCR2 ligand.
CSN17319 2-(((1R,2R,3aS,9aS)-2-Hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid, sodium salt 289480-64-4 Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
CSN17281 NIBR189 1599432-08-2 NIBR189 is a potent and selective EBI2 (GPR183) receptor antagonist with IC50 value of 11nM.
CSN17385 MK-2894 Sodium 1006036-88-9 MK-2894 sodium is a highly potent and selective second generation EP4 antagonist.
CSN17637 GSK 525768A 1260530-25-3 GSK525768A is the enantiomer compound of GSK 525762A, which is a potent small molecule inhibitor that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4) and has NO activity towards BET.
CSN17529 Zileuton sodium 118569-21-4 Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
CSN17435 Mizolastine 2HCl 1056596-82-7 Mizolastine 2HCl is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
CSN17489 GDC-0834 Racemate 1133432-46-8 GDC-0834 racemate is the racemate form of GDC-0834, which is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively.
CSN17618 GR79236 124555-18-6 GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.
CSN17541 JNJ-42041935 1193383-09-3 JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 ± 0.04, 7.29 ± 0.05, and 7.65 ± 0.09 for PHD1, PHD2, and PHD3, respectively.
CSN17233 TBA-7371 1494675-86-3 DprE1-IN-1, a potent DprE1 inhibitor, with ic50 of 10 nM, also inhibits PDE6, with IC50 of 6 μM.
CSN17391 IRAK inhibitor 4 1012104-68-5 IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor.
CSN17511 FK 3311 116686-15-8 FK 3311 is a selective inhibitor of COX-2 and an antiinflammatory agent.
CSN17715 AM095 1345614-59-6 AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
CSN17563 CaMKII-IN-1 1208123-85-6 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM, displaying significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.
CSN17276 Q-VD-OPh 1135695-98-5 Q-VD-OPh is a potent pan-caspase inhibitor of caspases 1, 3, 8, and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
CSN17418 IRAK inhibitor 1 1042224-63-4 IRAK inhibitor 1 is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor.
CSN17419 IRAK inhibitor 6 1042672-97-8 IRAK Inhibitor 6 is an improved IRAK-4 inhibitor with IC50 value of 160 nM.
CSN17490 GDC-0834 1133432-49-1 GDC-0834 is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively.
CSN17556 SRT3109 1204707-71-0 SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
CSN17565 N6022 1208315-24-5 N6022 reversibly inhibits s-nitrosoglutathione reductase (GSNOR) with IC50 and Ki of 8 nM, 2.5 nM, respectively.
CSN17582 E6446 1219925-73-1 E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
CSN17706 BMS-5 1338247-35-0 BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively.
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