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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN16124 | Ki20227 | 623142-96-1 | Ki-20227 is a highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50 value of 2 nM, displaying 6 fold and > 100 fold selectivity over VEGFR2 (IC50=12 nM) and c-Kit/PDGFRβ (IC50=451/217 nM), respectively. |
CSN16577 | Givinostat HCl monohydrate | 732302-99-7 | ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
CSN15955 | (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one | 29838-67-3 | Astilbin is a flavonoid compound that can enhance NRF2 activition with anti-inflammatory properties. It could be extracted from chinese astilbe. Astilbin has been found to have significant immunosuppressive effects in recent years. |
CSN15996 | WZ811 | 55778-02-4 | WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM. |
CSN16059 | Fostamatinib disodium hexahydrate | 914295-16-2 | R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity. |
CSN16151 | Plerixafor octaHCl | 155148-31-5 | Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
CSN16160 | (2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-Carboxy-2-(((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid | 1405-86-3 | Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1. |
CSN16174 | Diclofenac Sodium Salt | 15307-79-6 | Diclofenac sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. |
CSN16206 | Ozanimod | 1306760-87-1 | Ozanimod is an oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC). |
CSN16212 | BMS-1 | 1675201-83-8 | PD-1/PD-L1 inhibitor 1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM. |
CSN16343 | 2,4,5-Trimethoxybenzaldehyde | 4460-86-0 | Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott. |
CSN16440 | Wogonin | 632-85-9 | Wogonin acts as an inhibitor of COX2 with IC50 of 46 μM without affecting COX-1 and inhibits the NF-κB pathway-mediated iNOs induction. Wogonin can be isolated from the root of scutellaria baicalensis georgi. |
CSN16458 | Trimethoprim | 738-70-5 | Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections. |
CSN16462 | Leflunomide | 75706-12-6 | Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis. |
CSN16605 | Kirenol | 52659-56-0 | Kirenol is a naturall occuring diterpenoid found in S. orientalis, which possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities. |
CSN16392 | Sodium 2-hydroxybenzoate | 54-21-7 | Sodium Salicylate is anti-inflammatory drugs which can inhibit the activation of NF-kappa B. |
CSN15881 | CZC24832 | 1159824-67-5 | CZC-24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and > 100-fold selectivity over PI3Kα and PI3Kδ. |
CSN16072 | Levocetirizine 2HCl | 130018-87-0 | Levocetirizine 2HCl is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. |
CSN15958 | TAK-715 | 303162-79-0 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
CSN15918 | WS3 | 1421227-52-2 | WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM. |
CSN16503 | 7-Hydroxy-6-methoxy-2H-chromen-2-one | 92-61-5 | Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK. |
CSN15948 | Morroniside | 25406-64-8 | Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway. |
CSN16227 | BIO-acetoxime | 667463-85-6 | BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM. |
CSN16348 | GSK-J4 | 1373423-53-0 | GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor and attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). |
CSN16524 | SC-514 | 354812-17-2 | SC514 is a potent, reversible, ATP-competitive and highly selective IKK-β(IKK-2) inhibitor with IC50 value ranging in 3-12 µM. |
CSN16571 | Go6976 | 136194-77-9 | Gö6976 is a pan inhibitor of Ca2+-dependent PKC isozymes, PKCα and PKCβ1, with IC50 values of 2.3nM and 6.2nM, respectively, but has no effect on Ca2+-independent PKC isozymes PKCδ, ε and ζ. |
CSN16435 | Mebhydrolin napadisylate | 6153-33-9 | Mebhydrolin Napadisylate is an antihistamine that used for symptomatic relief of allergic symptoms. |
CSN16026 | GSK256066 | 801312-28-7 | GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, showing > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7. |
CSN16529 | AMD 3465 6HBr | 185991-07-5 | AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
CSN16345 | TBK1/IKKε-IN-2 | 1292310-49-6 | IKKε-IN-1 is a potent IKKε inhibitor. It inhibits the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. |
CSN16168 | Diphenhydramine HCl | 147-24-0 | Diphenhydramine HCl is a histamine H1 antagonist that is used as an antiemetic and antitussive. |
CSN15857 | Otenaproxesul | 1226895-20-0 | ATB-346 is a hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. |
CSN16563 | Lck Inhibitor | 847950-09-8 | Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. |
CSN15947 | Resatorvid | 243984-11-4 | TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
CSN16221 | K-7174 2HCl | 191089-60-8 | K-7174 2HCl is a cell adhesion inhibitor and inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α. |
CSN16012 | trans-Tranilast | 70806-55-2 | trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. |
CSN16337 | 6-OAU | 83797-69-7 | 6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
CSN15950 | Reparixin | 266359-83-5 | Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models. |
CSN16192 | Hydroxyzine 2HCl | 2192-20-3 | Hydroxyzine 2HCl is an antagonist of histamine H1-receptor that inhibits the binding of [3H]pyrilamine and [3H]desloratadine to histamine H1 receptor with IC50s of 10 nM and 19 nM. |
CSN16453 | 2-Hydroxybenzoic acid | 69-72-7 | Salicylic acid, a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. |
CSN16316 | APY0201 | 1232221-74-7 | APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. It is a unique small molecular IL-12/23 production inhibitor. |
CSN16482 | AZD1981 | 802904-66-1 | AZD1981 is a potent and selective CRTh2 antagonist and displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4). |
CSN16492 | ITK inhibitor | 439574-61-5 | ITK inhibitor is a potent ITK inhibitor of interleukin-2-inducible T-cell kinase. |
CSN16532 | BAY 61-3606 2HCl | 648903-57-5 | BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). |
CSN16322 | BMS-509744 | 439575-02-7 | BMS-509744 is a potent and selective Itk kinase inhibitor with an IC50 value of 19 nM. |
CSN15892 | RN486 | 1242156-23-5 | RN486 is a selective Btk inhibitor with an IC50 Value of 4.0 nM. |
CSN15928 | Licofelone | 156897-06-2 | Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis. |
CSN15987 | Cenicriviroc | 497223-25-3 | Cenicriviroc is an oral, dual CCR2/CCR5 antagonist, and displays potent anti-inflammatory and aninfective activity. |
CSN16018 | 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide | 745833-23-2 | VX-702 is a highly selective inhibitor of p38α MAPK with IC50 of 4 -20 nM. |