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Inflammation/Immunology

货号 产品名 CAS号 信息
CSN16124 Ki20227 623142-96-1 Ki-20227 is a highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50 value of 2 nM, displaying 6 fold and > 100 fold selectivity over VEGFR2 (IC50=12 nM) and c-Kit/PDGFRβ (IC50=451/217 nM), respectively.
CSN16577 Givinostat HCl monohydrate 732302-99-7 ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.
CSN15955 (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one 29838-67-3 Astilbin is a flavonoid compound that can enhance NRF2 activition with anti-inflammatory properties. It could be extracted from chinese astilbe. Astilbin has been found to have significant immunosuppressive effects in recent years.
CSN15996 WZ811 55778-02-4 WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM.
CSN16059 Fostamatinib disodium hexahydrate 914295-16-2 R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity.
CSN16151 Plerixafor octaHCl 155148-31-5 Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
CSN16160 (2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-Carboxy-2-(((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid 1405-86-3 Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.
CSN16174 Diclofenac Sodium Salt 15307-79-6 Diclofenac sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.
CSN16206 Ozanimod 1306760-87-1 Ozanimod is an oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC).
CSN16212 BMS-1 1675201-83-8 PD-1/PD-L1 inhibitor 1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.
CSN16343 2,4,5-Trimethoxybenzaldehyde 4460-86-0 Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott.
CSN16440 Wogonin 632-85-9 Wogonin acts as an inhibitor of COX2 with IC50 of 46 μM without affecting COX-1 and inhibits the NF-κB pathway-mediated iNOs induction. Wogonin can be isolated from the root of scutellaria baicalensis georgi.
CSN16458 Trimethoprim 738-70-5 Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections.
CSN16462 Leflunomide 75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN16605 Kirenol 52659-56-0 Kirenol is a naturall occuring diterpenoid found in S. orientalis, which possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.
CSN16392 Sodium 2-hydroxybenzoate 54-21-7 Sodium Salicylate is anti-inflammatory drugs which can inhibit the activation of NF-kappa B.
CSN15881 CZC24832 1159824-67-5 CZC-24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and > 100-fold selectivity over PI3Kα and PI3Kδ.
CSN16072 Levocetirizine 2HCl 130018-87-0 Levocetirizine 2HCl is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine.
CSN15958 TAK-715 303162-79-0 TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
CSN15918 WS3 1421227-52-2 WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM.
CSN16503 7-Hydroxy-6-methoxy-2H-chromen-2-one 92-61-5 Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK.
CSN15948 Morroniside 25406-64-8 Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway.
CSN16227 BIO-acetoxime 667463-85-6 BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM.
CSN16348 GSK-J4 1373423-53-0 GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor and attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release).
CSN16524 SC-514 354812-17-2 SC514 is a potent, reversible, ATP-competitive and highly selective IKK-β(IKK-2) inhibitor with IC50 value ranging in 3-12 µM.
CSN16571 Go6976 136194-77-9 Gö6976 is a pan inhibitor of Ca2+-dependent PKC isozymes, PKCα and PKCβ1, with IC50 values of 2.3nM and 6.2nM, respectively, but has no effect on Ca2+-independent PKC isozymes PKCδ, ε and ζ.
CSN16435 Mebhydrolin napadisylate 6153-33-9 Mebhydrolin Napadisylate is an antihistamine that used for symptomatic relief of allergic symptoms.
CSN16026 GSK256066 801312-28-7 GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, showing > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7.
CSN16529 AMD 3465 6HBr 185991-07-5 AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).
CSN16345 TBK1/IKKε-IN-2 1292310-49-6 IKKε-IN-1 is a potent IKKε inhibitor. It inhibits the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
CSN16168 Diphenhydramine HCl 147-24-0 Diphenhydramine HCl is a histamine H1 antagonist that is used as an antiemetic and antitussive.
CSN15857 Otenaproxesul 1226895-20-0 ATB-346 is a hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
CSN16563 Lck Inhibitor 847950-09-8 Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.
CSN15947 Resatorvid 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN16221 K-7174 2HCl 191089-60-8 K-7174 2HCl is a cell adhesion inhibitor and inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
CSN16012 trans-Tranilast 70806-55-2 trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
CSN16337 6-OAU 83797-69-7 6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.
CSN15950 Reparixin 266359-83-5 Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models.
CSN16192 Hydroxyzine 2HCl 2192-20-3 Hydroxyzine 2HCl is an antagonist of histamine H1-receptor that inhibits the binding of [3H]pyrilamine and [3H]desloratadine to histamine H1 receptor with IC50s of 10 nM and 19 nM.
CSN16453 2-Hydroxybenzoic acid 69-72-7 Salicylic acid, a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity.
CSN16316 APY0201 1232221-74-7 APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. It is a unique small molecular IL-12/23 production inhibitor.
CSN16482 AZD1981 802904-66-1 AZD1981 is a potent and selective CRTh2 antagonist and displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).
CSN16492 ITK inhibitor 439574-61-5 ITK inhibitor is a potent ITK inhibitor of interleukin-2-inducible T-cell kinase.
CSN16532 BAY 61-3606 2HCl 648903-57-5 BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
CSN16322 BMS-509744 439575-02-7 BMS-509744 is a potent and selective Itk kinase inhibitor with an IC50 value of 19 nM.
CSN15892 RN486 1242156-23-5 RN486 is a selective Btk inhibitor with an IC50 Value of 4.0 nM.
CSN15928 Licofelone 156897-06-2 Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
CSN15987 Cenicriviroc 497223-25-3 Cenicriviroc is an oral, dual CCR2/CCR5 antagonist, and displays potent anti-inflammatory and aninfective activity.
CSN16018 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide 745833-23-2 VX-702 is a highly selective inhibitor of p38α MAPK with IC50 of 4 -20 nM.
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