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Infection

货号 产品名 CAS号 信息
CSN20392 MDL-28170 88191-84-8 MDL28170 is a potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. MDL28170 rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
CSN20412 RN-18 431980-38-0 RN-18 is an HIV-1 viral infectivity factor (Vif) inhibitor with IC50 value ranging in 10-30 µM for inhibition of Vif-mediated degradation of the DNA editing enzyme APOBEC3G.
CSN20457 Bay 41-4109 racemate 298708-79-9 BAY-41-4109 racemate can inhibit human hepatitis B virus (HBV) with IC50 of 53 nM.
CSN20573 N-Benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide 22994-85-0 Benznidazole is an antiparasitic medication used in the treatment of Chagas disease.
CSN52409 N-Benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide 22994-85-0
CSN20580 Sulfaclozine sodium 23307-72-4 Sodium Sulfaclozine is a competitive antagonist of PABA (para-aminobenzoic acid).
CSN20305 Lanopepden 1152107-25-9 GSK-1322322 is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 has bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log (10) decrease in the number of CFU/mL at 4× MIC within 24 h in 29 of the 33 strains tested.
CSN20575 Cefteram 82547-58-8 Cefteram is a third-generation cephalosporin antibiotic.
CSN20414 Delpazolid 1219707-39-7 LCB01-0371 shows good activity against Gram-positive pathogens.
CSN20568 Vaborbactam 1360457-46-0 Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor showing broad-spectrum inhibitor, notably restoring the activity of carbapenems against KPC-producing strains.
CSN20407 TLR7 agonist 2 1642857-69-9 TLR7 agonist C54 is a potent and selective TLR7 agonist which effectively induces a transient interferon stimulated gene (ISG) response in mice and cynomolgus monkeys, and demonstrates th potential for the immunotherapy of hepatitis B virus.
CSN20343 (2R,5S,13aR)-8-Hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 1611493-60-7 Bictegravir is a potent, unboosted, once-Daily HIV-1 Integrase Strand Transfer inhibitor (INSTI) (IC50 - 1.6 nM) with improved pharmacokinetics and in vitro resistance profile.
CSN20438 GSK8175 1423007-82-2 GSK2878175 is a pan-genotypic non-nucleoside NS5B polymerase inhibitor potentially for the treatment of HCV infection.
CSN20241 Censavudine 634907-30-5 Censavudine is a nucleoside reverse transcriptase inhibitor that is active against HIV resistant to both abacavir and tenofovir, making the drug a candidate for people with multi-drug resistant (MDR) strains of the virus.
CSN20572 Zidebactam 1436861-97-0 Zidebactam is an inhibitor of PBP2 showing potent "β-lactam enhancer" activity against Pseudomonas aeruginosa, including multidrug-resistant metallo-β-lactamase-producing high-risk clones.
CSN20472 Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) 8064-90-2 Co-trimoxazole is an antibiotic used to treat a variety of bacterial infections including urinary tract infections, MRSA skin infections, travelers' diarrhea, respiratory tract infections, and cholera.
CSN20564 Temocillin 66148-78-5 Temocillin, a 6-α-methoxy derivative of ticarcillin, is a β-lactamase-resistant penicillin used primarily for the treatment of multiple drug-resistant, Gram-negative bacteria.
CSN20551 MDL-73811 123642-27-3 MDL 73811 is an inhibitor of S-adenosylmethionine decarboxylase for treating human african trypanosomiasis (HAT) caused by eukaryotic parasite Trypanosoma brucei.
CSN20499 (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6,20-bis((R)-1-hydroxyethyl)-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexaone 79411-15-7 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B is an analogue of antifungal lipopeptide echinocandin B.
CSN20471 Arcyriaflavin A 118458-54-1 Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM) and CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). It can also inhibit human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM).
CSN20463 Laninamivir octanoate hydrate 1233643-88-3 Laninamivir octanoate is a neuraminidase inhibitor that exhibits clinical efficacy for both treatment and prophylaxis of influenza virus infection, resulting from hydrolytic bioactivation into its pharmacologically active metabolite laninamivir in the pulmonary tissue.
CSN20464 Laninamivir octanoate 203120-46-1 Laninamivir octanoate is a neuraminidase inhibitor that exhibits clinical efficacy for both treatment and prophylaxis of influenza virus infection, resulting from hydrolytic bioactivation into its pharmacologically active metabolite laninamivir in the pulmonary tissue.
CSN20468 TAM-16 2030241-59-7 TAM16 is a benzofuran class inhibitor of polyketide synthase 13 (Pks13) with highly potent in vitro bactericidal activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis.
CSN20359 UMB-32 1635437-39-6 UMB-32 is an inhibitor of the BET bromodomain BRD4 (Kd = 550 nM; IC50 = 637 nM) and the bromodomain-containing transcription factor TAF1 (Kd = 560 nM) and TAF1L (Kd = 1.3 µM).
CSN20360 UMB-136 2109805-83-4 UMB-136 is a bromodomain, and extra-terminal domain inhibitor (BETi) that enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.
CSN20349 Antimalarial C46 2025371-99-5 Antimalarial C46 is an amide pyrazinyloxy benzoxaborole and a preclinical candidate for treating malaria.
CSN20406 Brd4592 2119598-24-0 BRD4592, a synthetic azetidine derivative, kills Mycobacterium tuberculosis (Mtb) through allosteric inhibition of tryptophan synthase (TrpAB), a previously untargeted, highly allosterically regulated enzyme.
CSN20364 PEP Inhibitor C1 2109805-71-0 PEP inhibitor C1 inhibits a wide variety of the peptidase domains of bacterial ComA-like ABC transporters, including those of Streptococcus commensal species, some of which may function in the maintenance of the commensal flora. Thus, it should be noted that this inhibitor might disturb the beneficial effect of the nasopharyngeal commensals when used as a drug.
CSN20409 VT-1598 2089320-99-8 VT1598 is a highly-selective, broad spectrum fungal CYP51 inhibitor, exhibiting excellent potency against yeast, dermatophyte, and mold fungal pathogens.
CSN20487 MK-8876 1426960-33-9 MK-8876 is a HCV NS5B Site D Inhibitor.
CSN20390 ETX2514 1467157-21-6 ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
CSN20377 PC786 1902114-15-1 PC786 is a potent anti-RSV agent via inhibition of RdRp activity, making topical treatment with this compound a potential therapy for the treatment of human RSV infections.
CSN20308 TXA6101 1459695-66-9 TXA6101, an inhibitor of essential bacterial protein FtsZ, retains activity against MRSA isolates that express either G196S or G193D mutant FtsZ, which confer resistance to TXA707.
CSN61348 Echinocandin B Nucleus Hydrochloride 1029890-89-8
CSN20260 (R)-5-((3-((6,8-Dibromochroman-4-yl)amino)propyl)amino)thieno[3,2-b]pyridin-7(4H)-one 1013915-71-3 CRS-3123 is a methionyl-tRNA synthetase inhibitor potentially for the treatment of enteric infections.
CSN20249 GSK2236805 1256390-53-0 GSK-2336805 is a HCV NS5A inhibitor potentially for the treatment of HCV infection.
CSN20288 Antimalarial C86(+) N/A Antimalarial C86(+) is an antimalarial inhibitor targeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy.
CSN20333 M4284 1373346-85-0 M4284, a high-affinity inhibitory mannoside targeting FimH, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota.
CSN20280 LBM-415 478913-91-6 LBM-415 is a peptide deformylase (PDF) inhibitor.
CSN20289 MDL-860 78940-62-2 MDL-860 is a broad-spectrum anti-picornavirus compound and one of the few promising candidates effective in in vivo virus infection.
CSN20342 Syk Inhibitor II dihydrochloride 227449-73-2 SYK inhibitor II is an inhibitor of SYK.
CSN20335 MBX2329 1438272-42-4 MBX2329 is a small molecule inhibitor of influenza virus H1N1 hemagglutinin.
CSN20307 TXA707 1609670-89-4 TXA707, an inhibitor of essential bacterial protein FtsZ, is associated with potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to current standard-of-care antibiotics.
CSN20294 HRV Inhibitor C6g 2104030-01-3 HRV inhibitor C6g is a high potent small molecular inhibitor of human rhinoviruses (hRVs).
CSN20538 Voxvoganan 1166254-80-3 LTX-109 is a synthetic antimicrobial peptide, showing activity against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus.
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