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JAK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN26377 | WHI-P258 | 21561-09-1 | WHI-P258 is a quinazoline compound that binds to the active site of JAK3 with an estimated Ki of 72 µM, but does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2]. |
| CSN20642 | SD1029 | 118372-34-2 | SD1029 is a cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. |
| CSN23211 | ZM 449829 | 4452-06-6 | Potent, selective JAK3 inhibitor |
| CSN23010 | NSC 33994 | 82058-16-0 | NSC 33994 is a selective inhibitor of JAK2 with IC50 of 60 nM. |
| CSN23158 | TCS 21311 | 1260181-14-3 | NIBR3049, also known as TCS-21311, is a potent and selective JAK3 inhibitor IC50 values of 8 nM.. |
| CSN26689 | FM-479 | 2226521-64-6 | FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. |
| CSN18801 | FLLL32 | 1226895-15-3 | FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of < 5 μM. |
| CSN19970 | Curculigoside | 85643-19-2 | Curculigoside, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn., can prevent bone loss, improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders.Curculigoside can also promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character, and possesses potent antioxidant properties against oxidative stress insults. |
| CSN22692 | Atiprimod 2HCl | 130065-61-1 | Atiprimod 2HCl is an inhibitor JAK2 with IC50 of 397 nM. |
| CSN13724 | AG-490 | 133550-30-8 | AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 = 2 μM), ErbB2 (IC50 = 13.5 μM), STAT3 and JAK2. |
