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JAK

JAK

货号 产品名 CAS号 信息
CSN26377 WHI-P258 21561-09-1 WHI-P258 is a quinazoline compound that binds to the active site of JAK3 with an estimated Ki of 72 µM, but does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].
CSN20642 SD1029 118372-34-2 SD1029 is a cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor.
CSN23211 ZM 449829 4452-06-6 Potent, selective JAK3 inhibitor
CSN23010 NSC 33994 82058-16-0 NSC 33994 is a selective inhibitor of JAK2 with IC50 of 60 nM.
CSN23158 TCS 21311 1260181-14-3 NIBR3049, also known as TCS-21311, is a potent and selective JAK3 inhibitor IC50 values of 8 nM..
CSN26689 FM-479 2226521-64-6 FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
CSN18801 FLLL32 1226895-15-3 FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of < 5 μM.
CSN19970 Curculigoside 85643-19-2 Curculigoside, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn., can prevent bone loss, improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders.Curculigoside can also promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character, and possesses potent antioxidant properties against oxidative stress insults.
CSN22692 Atiprimod 2HCl 130065-61-1 Atiprimod 2HCl is an inhibitor JAK2 with IC50 of 397 nM.
CSN13724 AG-490 133550-30-8 AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 = 2 μM), ErbB2 (IC50 = 13.5 μM), STAT3 and JAK2.
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