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K-Ras (G12C)/PROTAC refers to the PROTAC target K-Ras (G12C).

K-Ras (G12C)/PROTAC

货号 产品名 CAS号 信息
CSN28451 K-Ras PROTAC 2378258-52-5 PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC targeting on K-Ras and exhibits ≥70% degradation efficacy in SW1573 cells.
CSN27182 LC-2 2502156-03-6 LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.
CSN62987 MRTX1133 2621928-55-8
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