K-Ras (G12C)/PROTAC

K-Ras (G12C)/PROTAC refers to the PROTAC target K-Ras (G12C).

K-Ras (G12C)/PROTAC
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货号	产品名	CAS号	信息
CSN27182	LC-2	2502156-03-6	LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.