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Lipoxygenase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17529 | Zileuton sodium | 118569-21-4 | Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. |
| CSN12237 | Zileuton | 111406-87-2 | Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 µM in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 µM in purified human peripheral blood polymorphonuclear leukocytes (PMNL). |
| CSN21861 | Timegadine | 71079-19-1 | Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase. |
| CSN23549 | 1-Phenyl-3-pyrazolidinone | 92-43-3 | Phenidone inhibited both the lipoxygenase and Cox pathways |
| CSN23023 | PD146176 | 4079-26-9 | PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor with Ki of 197 nM. |
| CSN17912 | ML355 | 1532593-30-8 | ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 µM, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM). |
| CSN23745 | ML351 | 847163-28-4 | ML351 is a novel chemotype and the first reported selective inhibitor of 15-LOX-1 with IC50 value of 200 nM. |
| CSN11356 | Malotilate | 59937-28-9 | Malotilate is hepatotrophic drug which can selectively inhibit the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways were stimulated, with antifibrotic and hepatoprotective properties. |
| CSN25325 | FPL 62064 | 103141-09-9 | FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity. |
| CSN12630 | 6,7-Dihydroxy-2H-chromen-2-one | 305-01-1 | Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 2.5 µM, respectively. |
| CSN21626 | Enazadrem | 107361-33-1 | Enazadrem is a 5-lipoxygenase inhibitor with anti-inflammatory activity. |
| CSN20248 | CarbORev-5901 | 104325-75-9 | CarbORev-5901 is a carborane-based inhibitor of the 5-lipoxygenase pathway. |
| CSN21974 | Bunaprolast | 99107-52-5 | Bunaprolast is a potent inhibitor of LTB4 production in human whole blood and also exhibits significant inhibition of lipoxygenase and TXB2 release. |
| CSN26550 | COX/5-LO-IN-1 | 154355-75-6 | Atreleuton racemic is a racemic mixture of Atreleuton, is a 5-lipozygenase inhibitor used to treat asthma. Atreleuton, also known as ABT-761, VIA-2291, A-85761; Abbott-85761, is a reversible 5-lipoxygenase inhibitor. Atreleuton exhibits potent and selective inhibition of leukotriene formation. |
| CSN22333 | A-69412 | 123606-23-5 | A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO). |
| CSN13042 | 7,3',4'-Tri-O-methylluteolin | 29080-58-8 | 5-Hydroxy-3',4',7-trimethoxyflavone, a natural product isolated and purified fromt Lippia nodiflora L., shows prominent inhibitory activity against soybean lipoxygenase. |
| CSN22648 | (E)-2-(Thiophen-2-yl)ethyl 2-cyano-3-(3,4-dihydroxyphenyl)acrylate | 132465-10-2 | 2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC50s of 0.09, 0.013 and 0.5 μM respectively. |
| CSN17071 | 2-(3,4-Dihydroxyphenyl)ethanol | 10597-60-1 | 2-(3,4-Dihydroxyphenyl)ethanol is a potent and specific inhibitor of lipoxygenase activities, inhibits platelet 12-LO activity with IC50 of 4.2 mM and PMNL 5-LO activity with IC50 of 13 mM. It's a natural product isolated and purified from the herbs of Canarium album with antioxidant property. |
