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LOXL is essential for the elastic fibres homeostasis and for their maintenance at adult age.
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN23780 | PXS-5153A | 2125956-82-1 | PXS-5153A is a selective inhibitor of LOXL2 and LOXL3 with IC50 of <40 nM and 63 nM, respectively. |
CSN22481 | PAT-1251 | 2007885-39-2 | PAT-1251 is a potent, selective and oral Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 has entered clinical development with the potential to treat a number of fibrotic diseases. |
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