LOX

LOXL is essential for the elastic fibres homeostasis and for their maintenance at adult age.

LOX
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货号	产品名	CAS号	信息
CSN23780	PXS-5153A	2125956-82-1	PXS-5153A is a selective inhibitor of LOXL2 and LOXL3 with IC50 of <40 nM and 63 nM, respectively.
CSN22481	rel-(3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone	2007885-39-2	PAT-1251 is a potent, selective and oral Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 has entered clinical development with the potential to treat a number of fibrotic diseases.