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LPA Receptor

LPA Receptor

货号 产品名 CAS号 信息
CSN26691 TAK-615 1664335-55-0 TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].
CSN23706 Sodium (R,Z)-2-hydroxy-3-(oleoyloxy)propyl hydrogenphosphate 325465-93-8 Lysophosphatidic Acid is a water-soluble endogenous phospholipid in serum acting as ligand activator for EDG-2 and EDG-4 (LPA) receptors.
CSN16828 LPA2 antagonist 1 1017606-66-4 LPA2 antagonist 1 is an LPA2 antagonist with an IC50 of 17 nM.
CSN12695 Ki16425 355025-24-0 Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6.
CSN18649 Ki16198 355025-13-7 Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.
CSN33164 AS2717638 2148339-28-8 AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.
CSN13766 AM966 1228690-19-4 AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors.
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