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LPL Receptor

LPL Receptor

货号 产品名 CAS号 信息
CSN22133 W146 909725-61-7 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
CSN32539 VPC 23019 449173-19-7 VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
CSN18599 TY-52156 934369-14-9 TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor.
CSN17691 S1P1 agonist III 1324003-64-6 TC-G 1006 is a potent and orally active S1P1 agonist with EC50 of 18 nM, showing no activity on S1P3.
CSN32570 LX-2932 1055027-48-9 Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Ligands
CSN32572 Phosphonic acid, [(3S)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, mono(trifluoroacetate) 909725-64-0 Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Antagonists
CSN32564 BMS-520 1236188-38-7 Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Agonists
CSN32553 (S)-N-(3-(4-(5-(2-(Diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 1062670-13-6 Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Agonists
CSN23705 Sphingosine-1-phosphate 26993-30-6 Sphingosine 1-phosphate is the product of phosphorylation of sphingosine by sphingosine kinase and ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
CSN32517 Siponimod hemifumarate 1234627-85-0 Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis (MS). It is intended for once-daily oral administration.
CSN16315 Siponimod 1230487-00-9 Siponimod is a selective S1P1 receptor modulator with EC50 of 0.4 nM, approved for treatment for secondary progressive multiple sclerosis.
CSN10124 SEW?2871 256414-75-2 SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.
CSN19735 RP-001 hydrochloride 1781880-34-9 RP001 is a sphingosine-1-phosphate receptor 1 agonist which inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung.
CSN12827 Ponesimod 854107-55-4 Ponesimod is a selective S1P1 receptor modulator with EC50 of 5.7 nM, used in the reserch of treatment of multiple sclerosis (MS) and psoriasis.
CSN32516 Ozanimod hydrochloride 1618636-37-5 Ozanimod, sold under the brand name Zeposia, is an immunomodulatory medication for the treatment of relapsing multiple sclerosis (RMS) and ulcerative colitis.It acts as a sphingosine-1-phosphate (S1P) receptor agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation.
CSN16206 Ozanimod 1306760-87-1 Ozanimod is an oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC).
CSN18971 ONO-7300243 638132-34-0 ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM.
CSN13421 Mocravimod hydrochloride 509088-69-1 KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models.
CSN23237 JTE-013 383150-41-2 JTE 013 is a potent, selective S1P2 receptor antagonist with IC50 value of 17.6 nM.
CSN21216 GSK2018682 1034688-30-6 GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis. GSK-2018682 induced acute, transient and non-symptomatic decreases in heart rate and blood pressure.
CSN28759 GLPG2938 2130996-00-6 GLPG2938 is a pontent antagonist of S1P2 receptor, with exquisite potency on a phenotypic IL8 release assay, good pharmacokinetics, and good activity in a bleomycin-induced model of pulmonary fibrosis.
CSN32535 2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate 402615-91-2 FTY720 Phosphate is a derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine.
CSN25873 FTY720 (R)-Phosphate 402616-23-3 FTY720 (R)-Phosphate is the phosphate form of R-FTY720. Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells.
CSN12321 Fingolimod 162359-55-9 Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells.
CSN16720 Fingolimod hydrochloride   162359-56-0 Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM.
CSN16720 Fingolimod hydrochloride   162359-56-0 Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM.
CSN32922 Etrasimod arginine 1206123-97-8 Etrasimod arginine is Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) modulator.
CSN32511 1,4-Dicaffeoylquinic acid 1182-34-9 Cynarin comes from the flowerbud of Lonicera japonica Thunb. It has antioxidant property and inhibites HIV-1 replication in MT-2 cell culture at non-toxic concentrations, a potent and highly selective class of HIV-1 integrase inhibitors.
CSN43897 CYM50358 1314212-39-9 CYM50358 is a potent S1PR4 antagonist with an IC50 of 25 nM.
CSN20558 CYM5442 1094042-01-9 CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment.
CSN32519 Ceralifimod 891859-12-4 Ceralifimod (ONO-4641) is selective, high potent agonist for sphingosine 1-phosphate receptors 1 and 5, with EC50s of 27.3, 334 pM for human S1P receptor 1 and 5, respectively.
CSN22067 Cenerimod 1262414-04-9 Cenerimod is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist with an EC50 of 2.7 nM.
CSN32513 BMS-986104 1622180-31-7 BMS-986104 is a potent and selective S1P1 receptor modulator, which demonstrates ligand-biased signaling and differentiates from 1 in terms of cardiovascular and pulmonary safety based on preclinical pharmacology while showing equivalent efficacy in a T-cell transfer colitis model. Mechanistically, BMS-986104 exhibited excellent remyelinating effects on lysophosphatidylcholine (LPC) induced demyelination in a three-dimensional brain cell culture assay.
CSN18842 BMS-986020 1257213-50-5 BMS-986020 is an LPA1 antagonist.
CSN32510 Aurantiamide 58115-31-4 Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities.
CSN18986 Amiselimod hydrochloride 942398-84-7 Amiselimod HCl is a sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.
CSN17715 AM095 1345614-59-6 AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
CSN17359 AM095 free acid 1228690-36-5 AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
CSN32530 FTY720 (S)-Phosphate 402616-26-6 Agonist for Sphingosine 1-Phosphate receptors 1; Immunosuppressants
CSN32536 (S)-2-Amino-4-(4-(heptyloxy)phenyl)-2-methylbutan-1-ol 177258-60-5 Agonist for Sphingosine 1-Phosphate receptors 1; Asthma Therapy; Immunosuppressants
CSN26145 A-971432 1240308-45-5 A-971432 is a selective S1PR5 (Sphingosine-1-Phosphate Receptor 5) agonist with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively.
CSC32572 Phosphonic acid, [(3S)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, mono(trifluoroacetate) 909725-64-0
CSN106003 (1-amino-3-(3-octylphenyl)cyclobutyl)methanol 1392202-91-3
CSN105314 4-(4-(5-(5-Chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid hydrochloride 1034687-52-9
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