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LPL Receptor
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN22133 | W146 | 909725-61-7 | W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. |
CSN32539 | VPC 23019 | 449173-19-7 | VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively). |
CSN18599 | TY-52156 | 934369-14-9 | TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor. |
CSN17691 | S1P1 agonist III | 1324003-64-6 | TC-G 1006 is a potent and orally active S1P1 agonist with EC50 of 18 nM, showing no activity on S1P3. |
CSN32570 | LX-2932 | 1055027-48-9 | Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Ligands |
CSN32572 | Phosphonic acid, [(3S)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, mono(trifluoroacetate) | 909725-64-0 | Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Antagonists |
CSN32564 | BMS-520 | 1236188-38-7 | Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Agonists |
CSN32553 | (S)-N-(3-(4-(5-(2-(Diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide | 1062670-13-6 | Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Agonists |
CSN23705 | Sphingosine-1-phosphate | 26993-30-6 | Sphingosine 1-phosphate is the product of phosphorylation of sphingosine by sphingosine kinase and ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12. |
CSN32517 | Siponimod hemifumarate | 1234627-85-0 | Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis (MS). It is intended for once-daily oral administration. |
CSN16315 | Siponimod | 1230487-00-9 | Siponimod is a selective S1P1 receptor modulator with EC50 of 0.4 nM, approved for treatment for secondary progressive multiple sclerosis. |
CSN10124 | SEW?2871 | 256414-75-2 | SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo. |
CSN19735 | RP-001 hydrochloride | 1781880-34-9 | RP001 is a sphingosine-1-phosphate receptor 1 agonist which inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung. |
CSN12827 | Ponesimod | 854107-55-4 | Ponesimod is a selective S1P1 receptor modulator with EC50 of 5.7 nM, used in the reserch of treatment of multiple sclerosis (MS) and psoriasis. |
CSN32516 | Ozanimod hydrochloride | 1618636-37-5 | Ozanimod, sold under the brand name Zeposia, is an immunomodulatory medication for the treatment of relapsing multiple sclerosis (RMS) and ulcerative colitis.It acts as a sphingosine-1-phosphate (S1P) receptor agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation. |
CSN16206 | Ozanimod | 1306760-87-1 | Ozanimod is an oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC). |
CSN18971 | ONO-7300243 | 638132-34-0 | ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. |
CSN13421 | Mocravimod hydrochloride | 509088-69-1 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. |
CSN23237 | JTE-013 | 383150-41-2 | JTE 013 is a potent, selective S1P2 receptor antagonist with IC50 value of 17.6 nM. |
CSN21216 | GSK2018682 | 1034688-30-6 | GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis. GSK-2018682 induced acute, transient and non-symptomatic decreases in heart rate and blood pressure. |
CSN28759 | GLPG2938 | 2130996-00-6 | GLPG2938 is a pontent antagonist of S1P2 receptor, with exquisite potency on a phenotypic IL8 release assay, good pharmacokinetics, and good activity in a bleomycin-induced model of pulmonary fibrosis. |
CSN32535 | 2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate | 402615-91-2 | FTY720 Phosphate is a derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine. |
CSN25873 | FTY720 (R)-Phosphate | 402616-23-3 | FTY720 (R)-Phosphate is the phosphate form of R-FTY720. Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. |
CSN12321 | Fingolimod | 162359-55-9 | Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. |
CSN16720 | Fingolimod hydrochloride | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
CSN16720 | Fingolimod hydrochloride | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
CSN32922 | Etrasimod arginine | 1206123-97-8 | Etrasimod arginine is Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) modulator. |
CSN32511 | 1,4-Dicaffeoylquinic acid | 1182-34-9 | Cynarin comes from the flowerbud of Lonicera japonica Thunb. It has antioxidant property and inhibites HIV-1 replication in MT-2 cell culture at non-toxic concentrations, a potent and highly selective class of HIV-1 integrase inhibitors. |
CSN43897 | CYM50358 | 1314212-39-9 | CYM50358 is a potent S1PR4 antagonist with an IC50 of 25 nM. |
CSN20558 | CYM5442 | 1094042-01-9 | CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. |
CSN32519 | Ceralifimod | 891859-12-4 | Ceralifimod (ONO-4641) is selective, high potent agonist for sphingosine 1-phosphate receptors 1 and 5, with EC50s of 27.3, 334 pM for human S1P receptor 1 and 5, respectively. |
CSN22067 | Cenerimod | 1262414-04-9 | Cenerimod is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist with an EC50 of 2.7 nM. |
CSN32513 | BMS-986104 | 1622180-31-7 | BMS-986104 is a potent and selective S1P1 receptor modulator, which demonstrates ligand-biased signaling and differentiates from 1 in terms of cardiovascular and pulmonary safety based on preclinical pharmacology while showing equivalent efficacy in a T-cell transfer colitis model. Mechanistically, BMS-986104 exhibited excellent remyelinating effects on lysophosphatidylcholine (LPC) induced demyelination in a three-dimensional brain cell culture assay. |
CSN18842 | BMS-986020 | 1257213-50-5 | BMS-986020 is an LPA1 antagonist. |
CSN32510 | Aurantiamide | 58115-31-4 | Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities. |
CSN18986 | Amiselimod hydrochloride | 942398-84-7 | Amiselimod HCl is a sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. |
CSN17715 | AM095 | 1345614-59-6 | AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
CSN17359 | AM095 free acid | 1228690-36-5 | AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
CSN32530 | FTY720 (S)-Phosphate | 402616-26-6 | Agonist for Sphingosine 1-Phosphate receptors 1; Immunosuppressants |
CSN32536 | (S)-2-Amino-4-(4-(heptyloxy)phenyl)-2-methylbutan-1-ol | 177258-60-5 | Agonist for Sphingosine 1-Phosphate receptors 1; Asthma Therapy; Immunosuppressants |
CSN26145 | A-971432 | 1240308-45-5 | A-971432 is a selective S1PR5 (Sphingosine-1-Phosphate Receptor 5) agonist with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively. |
CSC32572 | Phosphonic acid, [(3S)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, mono(trifluoroacetate) | 909725-64-0 | |
CSN106003 | (1-amino-3-(3-octylphenyl)cyclobutyl)methanol | 1392202-91-3 | |
CSN105314 | 4-(4-(5-(5-Chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid hydrochloride | 1034687-52-9 |