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Melanocortin Receptor

货号 产品名 CAS号 信息
CSN21474 α-MSH 581-05-5 α-MSH is endogenous agonist of melanocortin receptor with Ki values of 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively.
CSN27581 THIQ 312637-48-2 THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
CSN26192 Shu 9119 168482-23-3 SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively. It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.
CSN21460 ACTH (1-39), Human 12279-41-3 ACTH (1-39) is agonist of melanocortin receptor 2 (MC2R) with an EC50 of 57 pM in HeLa cells expressing the mouse receptor.
CSN24141 ACTH (1-39) (mouse, rat) 77465-10-2 ACTH (1-39) (mouse, rat) is a potent melanocortin 2 (MC2) receptor agonist.
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