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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19930 | 8-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 76135-82-5 | Vitexin-4″-O-Glucoside can inhibit TPO activity. It is a natural product isolated and purified from the fruit of Crataegus pinnatifida Bge. |
| CSN18446 | JNJ-17203212 | 821768-06-3 | JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
| CSN18618 | BMS-303141 | 943962-47-8 | BMS-303141 is a potent ATPcitrate lyase (ACL) inhibitor with IC50 of 0.13 μM (human recombinant ACL). |
| CSN19073 | AS1842856 | 836620-48-5 | AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (Foxo1) with IC50 of 33 nM in HepG2 cells which directly bind to the active Foxo1. |
| CSN19427 | Rimonabant | 168273-06-1 | Rimonabant is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.8 nM. |
| CSN19437 | Topiroxostat | 577778-58-6 | Topiroxostat is an inhibitor of xanthine oxidoreductase (XOR) with IC50 of 5.3 nM. |
| CSN18543 | APD597 | 897732-93-3 | APD597 is an agonist of GPR119 with EC50 of 46 nM and is used for the treatment of type 2 diabetes. |
| CSN19742 | Idazoxan HCl | 79944-56-2 | Idazoxan is an alpha2-adrenoceptor antagonist potentially for the treatment of schizophrenia. |
| CSN19378 | Prostaglandin E1 | 745-65-3 | Alprostadil is an analog of prostaglandin which is prostaglandin E1 agonist with vasodilatory properties and can be used to treat erectile dysfunction. |
| CSN20010 | 2-Hydroxy-4-isopropylcyclohepta-2,4,6-trien-1-one | 499-44-5 | Hinokitiol, an iron chelator originally extracted from woods of Thuja plicata and Chamaecyparis obtuse, has been found to inhibit ultraviolet B-induced apoptosis in keratinocytes of murine ear skin via antioxidant activity of metallothionein. It can partially mimic the function of missing protein transporters of iron, and possibly other ions, may have potential in treating human diseases. |
| CSN19726 | 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride | 102676-31-3 | Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively. |
| CSN19255 | SR-18292 | 2095432-55-4 | SR-18292 is a potential molecule with inhibition of PGC-1α gluconeogenic activity for treating diabetes by reducing blood glucose, strongly increases hepatic insulin sensitivity and improving glucose homeostasis in dietary and genetic mouse models of T2D. |
| CSN19442 | Alverine citrate | 5560-59-8 | Alverine Citrate is a 5-HT1A receptor antagonist with IC50 value of 101 nM. |
| CSN18725 | Rbin-1 | 328023-11-6 | Rbin-1 inhibits ATPase with GI50 of 136±7 nM, it is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. |
| CSN20033 | CL 316243 | 138908-40-4 | CL-316243 is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM) and > 10000-fold selective over β1 and β2 receptors. CL-316243 restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice. |
| CSN19257 | LMPTP inhibitor 1 | 1908414-82-3 | LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
| CSN19904 | Neomangiferin | 64809-67-2 | Neomangiferin, a natural product isolated and purified from the herbs of Mangifera indica L. with beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats, and inhibits tartrate-resistant acid phosphatase, a biochemical marker of osteoclast function and bone resorption. |
| CSN19379 | 3-Hydroxy-3-methylpentanedioic acid | 503-49-1 | Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol. |
| CSN19126 | Emixustat | 1141777-14-1 | Emixustat, a visual cycle modulator, is an inhibitor of thevisual cycle isomerasewith an IC50 value of 4.4 nMin vitro. |
| CSN18945 | pemafibrate | 848259-27-8 | Pemafibrateis a selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity. |
| CSN18596 | (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5R)-5-Hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate | 93129-94-3 | Tacalcitol promotes normal bone development by regulating calcium. |
| CSN18429 | Imeglimin HCl | 775351-61-6 | Imeglimin HCl is the first in a tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. |
| CSN18972 | Taranabant ((1R,2R)stereoisomer) | 701977-08-4 | Taranabant(1R,2R)stereoisomer is the R-Enantiomer of taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist. |
| CSN18992 | Taspoglutide | 275371-94-3 | Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC50 value of 0.06 nM. |
| CSN19100 | TCS 401 | 243966-09-8 | TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). |
| CSN18404 | Calcitetrol | 72203-93-1 | Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups. |
| CSN18568 | Exendin-4 acetate | 914454-01-6 | Exendin-4 acetate is a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. |
| CSN19866 | Exendin-4 | 141758-74-9 | Exendin-4 is a high affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM) and originally isolated from Heloderma suspectum venom. |
| CSN19044 | CDD3505 | 173865-33-3 | CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
| CSN18617 | Genz-123346 | 943344-58-9 | Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1 and its IC50 for GM1 inhibition is 14 nM. |
| CSN19045 | CDD3506 | 197913-15-8 | CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
| CSN19036 | SR12813 | 126411-39-0 | SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM. |
| CSN18790 | Calcium (S)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoate dihydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
| CSN18480 | PF-915275 | 857290-04-1 | PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1(11βHSD1) (Ki < 1 nM) with good preclinical pharmacokinetic properties. |
| CSN18497 | AMG 837 sodium salt | 865231-45-4 | AMG-837 sodium is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
| CSN18946 | Pemafibrate racemate | 848258-31-1 | Pemafibrate racemate is a selective PPARα modulator (SPPARMα). |
| CSN19699 | AC-55649 | 59662-49-6 | AC55649 is an agonist of the retinoic acid receptor β (RAR-β). |
| CSN18755 | 24, 25-Dihydroxy VD3 | 40013-87-4 | 24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo. |
| CSN18405 | ZLN024 | 723249-01-2 | ZLN024 is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM. |
| CSN18969 | ZLN024 HCl | 1883548-91-1 | ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM. |
| CSN18988 | GRA Ex-25 | 307983-31-9 | GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. |
| CSN19038 | AM-2394 | 1442684-77-6 | AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM. |
| CSN19739 | LX2761 | 1610954-97-6 | LX2761 is a locally acting SGLT1 inhibitor that is highly potent in vitro and delays intestinal glucose absorption in vivo to improve glycemic control. LX2761 was designed to remain in the intestine after oral delivery to inhibit SGLT1 locally without affecting the SGLT1/2 mechanism in the kidney. |
| CSN19747 | BI-135585 | 1114561-85-1 | BI-135585 is a potent and selective 11β-HSD1 inhibitor for treating Type 2 diabetes. |
| CSN19749 | Zy15557 | 1601480-12-9 | ZY15557 is a potent, competitive and long acting DPP-4 inhibitor showing similar DPP-4 inhibition across different species. |
