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Metabolic Disease

货号 产品名 CAS号 信息
CSN16708 (R,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol 19356-17-3 Calcifediol is an active metabolite of vitamin D. It can inhibit the secretion of parathyroid hormone with 2 nM and commonly used as an indicator of body vitamin D status.
CSN16093 Dalcetrapib 211513-37-0 Dalcetrapib is a rhCETP inhibitor with IC50 of 0.2 μM.
CSN16153 (E)-2-(2,6-Dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid 923978-27-2 Elafibranor is an agonist of PPARα and PPARδ with EC50 values of 45 nM and 175 nM, respectively. Elafibranor also attenuates nonalcoholic steatohepatitis without fibrosis worsening.
CSN16203 Trelagliptin succinate 1029877-94-8 Trelagliptin succinate is an highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) that is used for the treatment of type 2 diabetes.
CSN16237 (2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate 928672-86-0 Canagliflozin selectively inhibits SGLT2 with IC50 of 2.2 nM.
CSN16291 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one 315-30-0 Allopurinol is xanthine oxidase inhibitor with IC50 of 7.82 ± 0.12 μM. It is used to treat kidney stones and gout.
CSN16305 Lesinurad sodium 1151516-14-1 Lesinurad sodium is an inhibitor of URAT1 and OAT and it is also a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
CSN16363 1,3,6,7-Tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-9H-xanthen-9-one 4773-96-0 Mangiferin is the predominant constituent of extracts of the mango plant Mangifera Indica L. with potential antidiabetic activity.
CSN16374 Clorgyline HCl 17780-75-5 Clorgiline HCl is an irreversible and selective MAO-A inhibitor.
CSN16403 L-Glutamine 56-85-9 L-Glutamine is an essential amino acid which serves as a substrate for biosynthesis of neurotransmitters glutamate and GABA in neurons.
CSN16455 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol 19130-96-2 1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. It's a natural product isolated and purified from the root barks of Morus alba L..
CSN16534 GSK137647A 349085-82-1 GSK137647A is an agonist of FFA4 with pEC50 of 6.3.
CSN16736 Cetilistat 282526-98-1 Cetilistat is a novel pancreatic lipase used to treat obesity.
CSN16739 Calcitriol 32222-06-3 Calcitriol is a vitamin D receptor agonist with IC50 of 0.4 nM.
CSN16781 Omeprazole 73590-58-6 Omeprazole is an inhibitor of proton pump with IC50 of 1.1 μM which can be used to treat dyspepsia.
CSN16882 2-((5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid 878672-00-5 Lesinurad is a URAT1 inhibitor with IC50 of 3.5 µM. It acts as a transporter that regulates uric acid excretion in kidney.
CSN16794 Glimepiride 93479-97-1 Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus.
CSN16260 Gemfibrozil 25812-30-0 Gemfibrozil is an agonist of PPARα. It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides.
CSN17234 PF-06291874 1393124-08-7 Glucagon receptor antagonists-4 is an selective antagonist of glucagon receptor.
CSN16861 Calcifediol monohydrate 63283-36-3 Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).
CSN16661 LXR-623 875787-07-8 LXR-623 is a novel and brain-penetrant LXR agonist with IC50 values of 179 and 24 nM for LXRα and LXRβ, respectively.
CSN17240 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid 738606-46-7 ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation.
CSN17002 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 486460-32-6 Sitagliptin is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts.
CSN16982 Tiplaxtinin 393105-53-8 Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.
CSN16574 trans-ACPD 67684-64-4 trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
CSN16950 Imeglimin 775351-65-0 Imeglimin is the first in a tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic β-cells to uniquely target the key defects of type 2 diabetes.
CSN16773 Terazosin 63590-64-7 Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH).
CSN16413 PSN632408 857652-30-3 PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 μM, respectively.
CSN16270 DGAT1-IN-1 1449779-49-0 DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM (cell lysate from Hep3B cells overexpressing human DGAT1).
CSN16902 Saroglitazar 495399-09-2 Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively.
CSN16256 GPR40 Activator 2 1312787-30-6 GPR40 activator 2 is a potent GPR40 activator.
CSN16084 MBX-2982 1037792-44-1 MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.
CSN16233 MF498 915191-42-3 MF498 is a selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM.
CSN16959 Pradigastat 956136-95-1 LCQ-908 is a potent and oral active diacylglycerol acyltransferase 1 (DGAT1) inhibitor, used as anti-obesity and anti-diabetic agents.
CSN16613 Otenabant HCl 686347-12-6 Otenabant HCl is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM.
CSN17177 (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide 928774-43-0 PF 03716556 is a selective H+,K+ ATPase inhibitor with pIC50 value of 6.009.
CSN16862 Eliglustat hemitartrate 928659-70-5 Eliglustat tartrate, a specific inhibitor of glucosylceramide synthase, is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1).
CSN16209 Trelagliptin 865759-25-7 Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
CSN16928 Balicatib 354813-19-7 Balicatib is a potent and selective inhibitor of cathepsin K ,with 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.
CSN16981 Palosuran 540769-28-6 Palosuran is a potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.
CSN16313 (3,5-Dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone 3562-84-3 Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM.
CSN16487 DGAT-1 inhibitor 2 942999-61-3 DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1 and an antiobesity agent.
CSN16133 MK-8245 1030612-90-8 MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
CSN16158 Anagliptin 739366-20-2 Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM) and > 10 fold less potent for DPP-8 and DPP-9.
CSN16830 Globalagliatin 1234703-40-2 LY2608204 is an activator of glucokinase (GK) with EC50 of 42 nM.
CSN16507 Orlistat 96829-58-2 Orlistat is an approved reversible general lipase inhibitor with IC50 of 122 ng/mL, used to treat obesity.
CSN50075 RTC13 1359825-94-7
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