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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN16708 | (R,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol | 19356-17-3 | Calcifediol is an active metabolite of vitamin D. It can inhibit the secretion of parathyroid hormone with 2 nM and commonly used as an indicator of body vitamin D status. |
CSN16093 | Dalcetrapib | 211513-37-0 | Dalcetrapib is a rhCETP inhibitor with IC50 of 0.2 μM. |
CSN16153 | (E)-2-(2,6-Dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid | 923978-27-2 | Elafibranor is an agonist of PPARα and PPARδ with EC50 values of 45 nM and 175 nM, respectively. Elafibranor also attenuates nonalcoholic steatohepatitis without fibrosis worsening. |
CSN16203 | Trelagliptin succinate | 1029877-94-8 | Trelagliptin succinate is an highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) that is used for the treatment of type 2 diabetes. |
CSN16237 | (2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate | 928672-86-0 | Canagliflozin selectively inhibits SGLT2 with IC50 of 2.2 nM. |
CSN16291 | 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one | 315-30-0 | Allopurinol is xanthine oxidase inhibitor with IC50 of 7.82 ± 0.12 μM. It is used to treat kidney stones and gout. |
CSN16305 | Lesinurad sodium | 1151516-14-1 | Lesinurad sodium is an inhibitor of URAT1 and OAT and it is also a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively. |
CSN16363 | 1,3,6,7-Tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-9H-xanthen-9-one | 4773-96-0 | Mangiferin is the predominant constituent of extracts of the mango plant Mangifera Indica L. with potential antidiabetic activity. |
CSN16374 | Clorgyline HCl | 17780-75-5 | Clorgiline HCl is an irreversible and selective MAO-A inhibitor. |
CSN16403 | L-Glutamine | 56-85-9 | L-Glutamine is an essential amino acid which serves as a substrate for biosynthesis of neurotransmitters glutamate and GABA in neurons. |
CSN16455 | (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol | 19130-96-2 | 1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. It's a natural product isolated and purified from the root barks of Morus alba L.. |
CSN16534 | GSK137647A | 349085-82-1 | GSK137647A is an agonist of FFA4 with pEC50 of 6.3. |
CSN16736 | Cetilistat | 282526-98-1 | Cetilistat is a novel pancreatic lipase used to treat obesity. |
CSN16739 | Calcitriol | 32222-06-3 | Calcitriol is a vitamin D receptor agonist with IC50 of 0.4 nM. |
CSN16781 | Omeprazole | 73590-58-6 | Omeprazole is an inhibitor of proton pump with IC50 of 1.1 μM which can be used to treat dyspepsia. |
CSN16882 | 2-((5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid | 878672-00-5 | Lesinurad is a URAT1 inhibitor with IC50 of 3.5 µM. It acts as a transporter that regulates uric acid excretion in kidney. |
CSN16794 | Glimepiride | 93479-97-1 | Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus. |
CSN16260 | Gemfibrozil | 25812-30-0 | Gemfibrozil is an agonist of PPARα. It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides. |
CSN17234 | PF-06291874 | 1393124-08-7 | Glucagon receptor antagonists-4 is an selective antagonist of glucagon receptor. |
CSN16861 | Calcifediol monohydrate | 63283-36-3 | Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). |
CSN16661 | LXR-623 | 875787-07-8 | LXR-623 is a novel and brain-penetrant LXR agonist with IC50 values of 179 and 24 nM for LXRα and LXRβ, respectively. |
CSN17240 | 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | 738606-46-7 | ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation. |
CSN17002 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one | 486460-32-6 | Sitagliptin is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. |
CSN16982 | Tiplaxtinin | 393105-53-8 | Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM. |
CSN16574 | trans-ACPD | 67684-64-4 | trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons. |
CSN16950 | Imeglimin | 775351-65-0 | Imeglimin is the first in a tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic β-cells to uniquely target the key defects of type 2 diabetes. |
CSN16773 | Terazosin | 63590-64-7 | Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). |
CSN16413 | PSN632408 | 857652-30-3 | PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 μM, respectively. |
CSN16270 | DGAT1-IN-1 | 1449779-49-0 | DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM (cell lysate from Hep3B cells overexpressing human DGAT1). |
CSN16902 | Saroglitazar | 495399-09-2 | Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively. |
CSN16256 | GPR40 Activator 2 | 1312787-30-6 | GPR40 activator 2 is a potent GPR40 activator. |
CSN16084 | MBX-2982 | 1037792-44-1 | MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes. |
CSN16233 | MF498 | 915191-42-3 | MF498 is a selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM. |
CSN16959 | Pradigastat | 956136-95-1 | LCQ-908 is a potent and oral active diacylglycerol acyltransferase 1 (DGAT1) inhibitor, used as anti-obesity and anti-diabetic agents. |
CSN16613 | Otenabant HCl | 686347-12-6 | Otenabant HCl is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM. |
CSN17177 | (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide | 928774-43-0 | PF 03716556 is a selective H+,K+ ATPase inhibitor with pIC50 value of 6.009. |
CSN16862 | Eliglustat hemitartrate | 928659-70-5 | Eliglustat tartrate, a specific inhibitor of glucosylceramide synthase, is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1). |
CSN16209 | Trelagliptin | 865759-25-7 | Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). |
CSN16928 | Balicatib | 354813-19-7 | Balicatib is a potent and selective inhibitor of cathepsin K ,with 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. |
CSN16981 | Palosuran | 540769-28-6 | Palosuran is a potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM. |
CSN16313 | (3,5-Dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone | 3562-84-3 | Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM. |
CSN16487 | DGAT-1 inhibitor 2 | 942999-61-3 | DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1 and an antiobesity agent. |
CSN16133 | MK-8245 | 1030612-90-8 | MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. |
CSN16158 | Anagliptin | 739366-20-2 | Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM) and > 10 fold less potent for DPP-8 and DPP-9. |
CSN16830 | Globalagliatin | 1234703-40-2 | LY2608204 is an activator of glucokinase (GK) with EC50 of 42 nM. |
CSN16507 | Orlistat | 96829-58-2 | Orlistat is an approved reversible general lipase inhibitor with IC50 of 122 ng/mL, used to treat obesity. |
CSN50075 | RTC13 | 1359825-94-7 |