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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12803 | Etomoxir sodium salt | 828934-41-4 | (R)-(+)-etomoxir sodium salt is inhibitor of carnitine palmitoyltransferase I (CPT1) and can reduce β-oxidation in mitochondria. It shows inhibition of cardiolipin biosynthesis. |
| CSN12855 | Terazosin HCl | 63074-08-8 | Terazosin HCl is a selective antagonist for alpha-adrenergic receptor, used for treatment for hypertension and prostate enlargement (BPH) through lowering the blood pressure with elimination half-life of 12 hours. |
| CSN12976 | 2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | 82159-09-9 | Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy. |
| CSN13091 | Fluvastatin Sodium Salt | 93957-55-2 | Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM. |
| CSN13484 | Odanacatib | 603139-19-1 | Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. |
| CSN13492 | D-Glutamine | 5959-95-5 | D-Glutamine is a non-essential amino acid involved in many metabolic processes such as forming the central metabolite in amino acid transamination. |
| CSN13558 | GSK1292263 | 1032823-75-8 | GSK1292263 is an agonist of GPR119 receptor that is used to treat type 2 diabetes. |
| CSN13656 | AZD7545 | 252017-04-2 | AZD7545 is a selective inhibitor of PDHK2 (PDH kinase2) with IC50s of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively. |
| CSN13745 | IOWH-032 | 1191252-49-9 | IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays. |
| CSN13774 | Tiopronin | 1953-02-2 | Tiopronin, derivative of glycine, is used to control the rate of cystine precipitation and excretion. It can be used as an antioxidant agent and radical scavenger. |
| CSN13801 | (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 864070-44-0 | Empagliflozin is a selective inhibitor of SGLT-2 with IC50 of 3.1 nM. |
| CSN13871 | Dapagliflozin ((2S)-1,2-propanediol, hydrate) | 960404-48-2 | Dapagliflozin propanediol is an inhibitor of SGLT2 that is used for the treatment of of type 2 diabetes mellitus. |
| CSN15574 | (2S,3R,4S,5S,6R)-2-(4-((1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)-3-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 487-41-2 | Phillyrin is a naturally occuring AMPK activity enhancer, isolated and purified from the fruits of Forsythia suspensa. |
| CSN15683 | Sotagliflozin | 1018899-04-1 | LX4211 is an inhibitor of SGLT2 and SGLT1 with antidiabetic activity. |
| CSN15715 | Evacetrapib | 1186486-62-3 | Evacetrapib is a potent and selective inhibitor of CETP with IC50 of 5.5 nM. |
| CSN15831 | (1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol | 1210344-57-2 | PF-04971729 is a selective sodium-dependent glucose cotransporter (SGLT) inhibitor which selectively targets SGLT2. |
| CSN15923 | Atglistatin | 1469924-27-3 | Atglistatin is a potent, selective and competitive ATGL with IC50 value of 0.7 μM. |
| CSN15985 | ZLN005 | 49671-76-3 | ZLN005 is a transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). |
| CSN16022 | Ipragliflozin | 761423-87-4 | Ipragliflozin is a selective inhibitor of SGLT2 with IC50 of 14 nM for hSGLT2. |
| CSN16061 | 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide | 924416-43-3 | AdipoRon is a selective agonist of AdipoR1 and AdipoR2 with Kd value of 1.8 μM and 3.1 μM, respectively, which can activate AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in a model of type II diabetes and obesity. |
| CSN13142 | GW0742 | 317318-84-6 | GW0742 is an agonist of PPARδ with EC50 of 1.1 nM. It can protect right heart from hypertrophy and enhance lipid metabolism in heart. It also works as an antagonist of vitamin D receptor. |
| CSN52399 | Isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate | 629664-81-9 | |
| CSN13122 | YO-01027 | 209984-56-5 | Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. |
| CSN13559 | PF-04620110 | 1109276-89-2 | PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
| CSN12914 | Vitamin D4 | 511-28-4 | Vitamin D4 is the active analogue of Vitamin D. |
| CSN13845 | (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine | 1226781-44-7 | Omarigliptin, also called MA-3102, is an selective inhibitor of DPP-4 with IC50 of 1.6 nM and Ki of 0.8 nM. Its selectivity is higher than other 168 proteasomes. |
| CSN15825 | TAK-875 Hemihydrate | 1374598-80-7 | TAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid. |
| CSN12991 | Ruboxistaurin HCl | 169939-93-9 | LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. |
| CSN13800 | Saxagliptin hydrate | 945667-22-1 | Saxagliptin, the monohydrate form of anhydrous saxagliptin, is a reversible and selective DPP4 inhibitor with IC50 of 26 nM. It is used for the treatment of type 2 diabetes. |
| CSN13516 | N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride | 66357-59-3 | Ranitidine HCl is an antagonist of histamine H2-receptor that can inhibit stomach acid production. |
| CSN12933 | (3R,5R)-3,5-Dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-(((S)-2-methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid | 81093-37-0 | Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| CSN13565 | MK 0893 | 870823-12-4 | MK 0893 is a potent, selective glucagon receptor antagonist with IC50 of 6.6 nM, showing > 200 fold selectivity for GIPR, PAC1, GLP-1R, VPAC1 and VPAC2. |
| CSN13509 | Talabostat mesylate | 150080-09-4 | Talabostat mesilate is an orally active, specific inhibitor of dipeptidyl peptidases with IC50 of 1 nM for DPP4, including tumor-associated fibroblast activation protein. |
| CSN13564 | AR 231453 | 733750-99-7 | AR 231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release, used as an antidiabetic agent. |
| CSN12947 | Fluvastatin | 93957-54-1 | Fluvastatin inhibits HMG-CoA reductase activity with IC50 of 8 nM. |
| CSN16029 | APD668 | 832714-46-2 | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.. |
| CSN13717 | TGR5 Receptor Agonist | 1197300-24-5 | TGR5 receptor agonist, a potent TGR5 (GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). |
| CSN13586 | (S)-2-(6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid | 1000413-72-8 | TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM. |
| CSN13687 | ABT-046 | 1031336-60-3 | ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM). |
| CSN12823 | N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide | 925434-55-5 | SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM). |
| CSN74265 | N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide | 925434-55-5 | |
| CSN13936 | TUG-891 | 1374516-07-0 | TUG-891 is a selective agonist of long chain free fatty acid (LCFA) receptor 4 (GPR120). |
| CSN13764 | Maxacalcitol | 103909-75-7 | Maxacalcitol is non-calcemic vitamin D3 analog and ligand of VDR-like receptors. |
| CSN15849 | Genz-123346 free base | 491833-30-8 | Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1 and IC50 for GM1 inhibition is 14 nM. |
| CSN16054 | Tofogliflozin | 903565-83-3 | Tofogliflozin is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. |
| CSN13154 | Sodium 2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonate | 35807-85-3 | Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells. |
| CSN13813 | Teneligliptin | 760937-92-6 | Teneligliptin is a potent and long-lasting dipeptidyl peptidase-4 inhibitor, and competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. |
