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mGluR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN24066 | VU6005649 | 2137047-43-7 | VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. |
| CSN23124 | Spaglumic Acid | 3106-85-2 | Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain. |
| CSN23116 | SIB 1757 | 31993-01-8 | SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8. |
| CSN23070 | Ro 64-5229 | 246852-46-0 | Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM). |
| CSN23187 | VU 29 | 890764-36-0 | Potent positive allosteric modulator of mGlu5 receptors |
| CSN23007 | NPS 2390 | 226878-01-9 | NPS 2390 is a Group I mGlu antagonist. |
| CSN22913 | MMPEP | 823198-78-3 | MPEP HCl is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM, and a mGlu4 receptor positive allosteric modulator. |
| CSN22978 | ML 337 | 1443118-44-2 | ML 337 is a selective negative allosteric modulator of mGlu3 with IC50 of 593 nM. |
| CSN22977 | ML 289 | 1382481-79-9 | ML 289 is a selective negative allosteric modulator at mGlu3 receptors with IC50 of 660 nM. |
| CSN13469 | Mavoglurant | 543906-09-8 | Mavoglurant is a structurally non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. |
| CSN22960 | MAP4 | 157381-42-5 | MAP4 is a potent group II mGlu agonist and also group III mGlu antagonist. |
| CSN18024 | LY354740 | 176199-48-7 | LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, produces > 90% suppression of forskolin-stimulated cAMP formation with an EC50 of 5.1 ± 0.3 nM. |
| CSN27529 | L-Cysteinesulfinic acid monohydrate | 207121-48-0 | L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively. |
| CSN22881 | L-CCG-l | 117857-93-9 | L-CCG-l is a potent group II metabotropic glutamate receptor agonist. |
| CSN18792 | IEM 1754 Dihydrobromide | 162831-31-4 | IEM 1754 dihydrobromide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
| CSN22849 | HexylHIBO | 334887-43-3 | HexylHIBO is a Group I mGlu receptor antagonist with Kis of 140 and 110 μM at mGlu1a and mGlu5a receptors respectively. |
| CSN23016 | H-Ser(PO3H2)-OH | 407-41-0 | H-Ser(PO3H2)-OH is both a Group III metabotropic glutamate receptor (mGluR4, mGluR7, and mGluR8) agonist, and a competitive NMDA antagonist. |
| CSN22789 | DL-AP3 | 5652-28-8 | DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. |
| CSN22778 | CPPG | 183364-82-1 | CPPG is a potent group II/III mGlu receptor antagonist, with IC50s of 46.2 and 2.2 nM respectively. |
| CSN22777 | CPCCOEt | 179067-99-3 | CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist with IC50 of 6.5 μM. |
| CSN22762 | Cinnabarinic Acid | 606-59-7 | Cinnabarinic Acid is a elective mGlu4 agonist. |
| CSN22756 | CHPG Sodium Salt | 1303993-73-8 | CHPG Sodium Salt is a selective mGlu5 agonist. |
| CSN22755 | CHPG | 170846-74-9 | CHPG is a selective mGlu5 metabotropic glutamate receptor agonist. |
