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mGluR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN23198 | XAP 044 | 196928-50-4 | XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice. |
CSN26264 | 4,8-Dihydroxyquinoline-2-carboxylic acid | 59-00-7 | Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus, which activates mGlu2/3 metabotropic glutamate receptors (mGlu2 and mGlu3). |
CSN24066 | VU6005649 | 2137047-43-7 | VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. |
CSN26379 | Tcn238 | 125404-04-8 | TCN238 is a orally available and brain penetrant positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. |
CSN23124 | Spaglumic Acid | 3106-85-2 | Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain. |
CSN23070 | Ro 64-5229 | 246852-46-0 | Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM). |
CSN23007 | NPS 2390 | 226878-01-9 | NPS 2390 is a Group I mGlu antagonist. |
CSN26699 | NPEC-caged-LY379268 | 1315379-62-4 | NPEC-caged-LY379268 is a type II mGluR agonist[1]. |
CSN29465 | L-Cysteinesulfinic acid | 1115-65-7 | NMDA and mGlu agonist. |
CSN22913 | MMPEP | 823198-78-3 | MPEP HCl is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM, and a mGlu4 receptor positive allosteric modulator. |
CSN22977 | ML 289 | 1382481-79-9 | ML 289 is a selective negative allosteric modulator at mGlu3 receptors with IC50 of 660 nM. |
CSN22960 | MAP4 | 157381-42-5 | MAP4 is a potent group II mGlu agonist and also group III mGlu antagonist. |
CSN18024 | LY354740 | 176199-48-7 | LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, produces > 90% suppression of forskolin-stimulated cAMP formation with an EC50 of 5.1 ± 0.3 nM. |
CSN22065 | Lu AF21934 | 1445605-23-1 | Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with IC50 of 500 nM for human mGlu4. |
CSN27529 | L-Cysteinesulfinic acid monohydrate | 207121-48-0 | L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively. |
CSN22881 | L-CCG-l | 117857-93-9 | L-CCG-l is a potent group II metabotropic glutamate receptor agonist. |
CSN18792 | IEM 1754 Dihydrobromide | 162831-31-4 | IEM 1754 dihydrobromide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
CSN22849 | HexylHIBO | 334887-43-3 | HexylHIBO is a Group I mGlu receptor antagonist with Kis of 140 and 110 μM at mGlu1a and mGlu5a receptors respectively. |
CSN23016 | H-Ser(PO3H2)-OH | 407-41-0 | H-Ser(PO3H2)-OH is both a Group III metabotropic glutamate receptor (mGluR4, mGluR7, and mGluR8) agonist, and a competitive NMDA antagonist. |
CSN26363 | FITM | 932737-65-0 | FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM. |
CSN22789 | DL-AP3 | 5652-28-8 | DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. |
CSN27612 | CDPPB | 781652-57-1 | CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. |
CSN24484 | (S)-4CPG | 134052-73-6 | (S)-4CPG is a selective competitive group I mGlu antagonist. |