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mGluR

mGluR

货号 产品名 CAS号 信息
CSN23198 XAP 044 196928-50-4 XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.
CSN26264 4,8-Dihydroxyquinoline-2-carboxylic acid 59-00-7 Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus, which activates mGlu2/3 metabotropic glutamate receptors (mGlu2 and mGlu3).
CSN24066 VU6005649 2137047-43-7 VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
CSN26379 Tcn238 125404-04-8 TCN238 is a orally available and brain penetrant positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM.
CSN23124 Spaglumic Acid 3106-85-2 Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
CSN23070 Ro 64-5229 246852-46-0 Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
CSN18031 PHCCC 179068-02-1 PHCCC is a Group I metabotropic glutamate receptor antagonist with EC 50 of 6 μM and a positive allosteric modulator of mGluR4.
CSN23007 NPS 2390 226878-01-9 NPS 2390 is a Group I mGlu antagonist.
CSN26699 NPEC-caged-LY379268 1315379-62-4 NPEC-caged-LY379268 is a type II mGluR agonist[1].
CSN29465 L-Cysteinesulfinic acid 1115-65-7 NMDA and mGlu agonist.
CSN22913 MMPEP 823198-78-3 MPEP HCl is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM, and a mGlu4 receptor positive allosteric modulator.
CSN22977 ML 289 1382481-79-9 ML 289 is a selective negative allosteric modulator at mGlu3 receptors with IC50 of 660 nM.
CSN22960 MAP4 157381-42-5 MAP4 is a potent group II mGlu agonist and also group III mGlu antagonist.
CSN18024 LY354740 176199-48-7 LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, produces > 90% suppression of forskolin-stimulated cAMP formation with an EC50 of 5.1 ± 0.3 nM.
CSN22065 Lu AF21934 1445605-23-1 Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with IC50 of 500 nM for human mGlu4.
CSN27529 L-Cysteinesulfinic acid monohydrate 207121-48-0 L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
CSN22881 L-CCG-l 117857-93-9 L-CCG-l is a potent group II metabotropic glutamate receptor agonist.
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
CSN22849 HexylHIBO 334887-43-3 HexylHIBO is a Group I mGlu receptor antagonist with Kis of 140 and 110 μM at mGlu1a and mGlu5a receptors respectively.
CSN23016 H-Ser(PO3H2)-OH 407-41-0 H-Ser(PO3H2)-OH is both a Group III metabotropic glutamate receptor (mGluR4, mGluR7, and mGluR8) agonist, and a competitive NMDA antagonist.
CSN26363 FITM 932737-65-0 FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.
CSN27612 CDPPB 781652-57-1 CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5.
CSN24484 (S)-4CPG 134052-73-6 (S)-4CPG is a selective competitive group I mGlu antagonist.
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