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mGluR

mGluR

货号 产品名 CAS号 信息
CSN20205 Auglurant 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN16002 VU0364770 61350-00-3 VU 0364770 is a brain-penetrant and positive allosteric modulator of mGlu4 receptors with EC50 values of 290 nM. It also exhibits affinity for MAO-B and MAO-A with Ki values of 0.72 μM and 8.5 μM, respectively.
CSN17179 VU 0364439 1246086-78-1 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
CSN16570 VU 0357121 433967-28-3 VU 0357121 is a positive allosteric mGlu5 receptors modulator with EC50 value of 33 nM.
CSN22529 UBP1112 339526-74-8 UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM, 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor.
CSN18975 Ro 67-7476 298690-60-5 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.
CSN15957 Ro 67-4853 302841-89-0 Ro 67-4853 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.
CSN20553 PF-06462894 1622291-66-0 PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator.
CSN22469 MSOP 66515-29-5 MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
CSN18318 Methoxy-PEPy 524924-76-3 Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.
CSN18984 Mavoglurant racemate 1636881-61-2 Mavoglurant racemate is the racemate of mavoglurant.
CSN16643 LY2979165 1311385-32-6 LY2979165 is a mGlu2 agonist, a drug candidate drug used to treat bipolar disorder.
CSN19844 LY456236 338736-46-2 LY 456236 HCl is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively).
CSN19861 LSN2463359 1401031-52-4 LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM).
CSN16403 L-Glutamine 56-85-9 L-Glutamine is an essential amino acid which serves as a substrate for biosynthesis of neurotransmitters glutamate and GABA in neurons.
CSN22881 L-CCG-I 117857-93-9 L-CCG-l is a potent group II metabotropic glutamate receptor agonist.
CSN22445 L-AP4 23052-81-5 L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13±0.02, 0.29±0.07, 1.0±0.3, 249±107 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
CSN18977 JNJ16259685 409345-29-5 JNJ16259685 is a selective antagonist at the mGlu1 receptors, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
CSN22437 JNJ-46778212 1363281-27-9 JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
CSN17481 JNJ-40411813 1127498-03-6 JNJ-40411813 is a positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
CSN22849 HexylHIBO 334887-43-3 HexylHIBO is a Group I mGlu receptor antagonist with Kis of 140 and 110 μM at mGlu1a and mGlu5a receptors respectively.
CSN20520 GET73 202402-01-5 GET-73 is a mGlu5 receptor allosteric modulator potentially for the treatment of alcoholism.
CSN22825 FTIDC 873551-53-2 FTIDC is a potent and selective mGlu1 receptor negative allosteric modulator with IC50 of 5.8 nM.
CSN18973 FPTQ 864863-72-9 FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.
CSN22789 2-Amino-3-phosphonopropanoic acid 5652-28-8 DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
CSN18512 Dipraglurant 872363-17-2 Dipraglurant is a mGluR5 antagonists with IC50 of 0.021 μM.
CSN18976 DFMTI 864864-86-8 DFMTI can completely block the rmGlu1 L757V glutamate response.
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN22778 CPPG 183364-82-1 CPPG is a potent group II/III mGlu receptor antagonist, with IC50s of 46.2 and 2.2 nM respectively.
CSN22777 CPCCOEt 179067-99-3 CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist with IC50 of 6.5 μM.
CSN22762 Cinnabarinic acid 606-59-7 Cinnabarinic Acid is a elective mGlu4 agonist.
CSN22756 CHPG sodium salt 1303993-73-8 CHPG Sodium Salt is a selective mGlu5 agonist.
CSN22755 CHPG 170846-74-9 CHPG is a selective mGlu5 metabotropic glutamate receptor agonist.
CSN18974 CFMTI 864864-17-5 CFMTI is a potent and selective metabotropic glutamate receptor (mGluR)1 allosteric antagonist with IC50 of 2.6 nM.
CSN22354 AZD-8529 1092453-15-0 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
CSN22705 AZD 9272 327056-26-8 AZD 9272 is a potent and selective mGlu5 antagonist with IC50s of 2.6 and 7.6 nM for rat and human receptors, respectively.
CSN22702 AZD 2066 934282-55-0 AZD 2066 is an orally bioavailable and brain penetrant mGlu5 antagonist.
CSN19841 UPF-523 168560-79-0 AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells.
CSN16339 ADX-47273 851881-60-2 ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 0.23 μM in primary astrocyte culture.
CSN22668 rel-ACPT-I 194918-76-8 ACPT-I is an agonist for group III mGlu receptors with EC50 of 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively.
CSN22662 3-((6-Methylpyridin-2-yl)ethynyl)cyclohex-2-en-1-one O-methyl oxime 924298-51-1 ABP 688 is a high affinity human mGlu5 receptor antagonist with Ki of 1.7 nM.
CSN22650 3-MATIDA 518357-51-2 3-MATIDA is a potent metabotropic glutamate mGlu1 receptor antagonist with IC50 of 6.3 μM at rat mGlu1a.
CSN17040 (S)-MCPG 150145-89-4 (S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.
CSN22637 (S)-HexylHIBO 334887-48-8 (S)-HexylHIBO is a Group I mGlu receptor antagonist with Kb of 30 and 61 μM at mGlu1a and mGlu5a receptors respectively.
CSN22634 (R)-2-Amino-2-(3,5-dihydroxyphenyl)acetic acid 117468-89-0 (S)-3,5-DHPG is a selective group I mGlu receptor agonist.
CSN22633 (S)-3,4-DCPG 201730-11-2 (S)-3,4-DCPG is a potent, selective mGlu8a agonist with EC50 of 31 nM.
CSN22632 (RS)-PPG 120667-15-4 (RS)-PPG is a potent and selective mGlu8 agonist.
CSN17028 (RS)-MCPG 146669-29-6 (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
CSN22630 (Rac)-3-Hydroxyphenylglycine 31932-87-3 (RS)-3-Hydroxyphenylglycine is a selective group I metabotropic glutamate receptor agonist.
CSN22629 DHPG 146255-66-5 (RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5.
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