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Microtubule/Tubulin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18754 | Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate | 2068-78-2 | Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM. |
| CSN16499 | Vinblastine | 865-21-4 | Vinblastine can inhibit the formation of microtubule, it also inhibit nAChR (IC50=8.9 μM). |
| CSN17793 | Vc-MMAD | 1401963-17-4 | Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate. |
| CSN20035 | Tubulysin B | 205304-87-6 | Tubulysin B is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. |
| CSN16451 | Triclabendazole | 68786-66-3 | Triclabendazole is a benzimidazole carbamate anthelmintic which can bind to beta-tublin and inhibits protein synthesis. |
| CSN18138 | Taltobulin trifluoroacetate | 228266-41-9 | Taltobulin trifluoroacetat is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin. |
| CSN18137 | Taltobulin | 228266-40-8 | Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin. |
| CSN18881 | Taltobulin hydrochloride | N/A | Taltobulin HCl is an cytotoxin, an analogue of hemiasterlin, and a potent tubulin inhibitor. |
| CSN19199 | TAI-1 | 1334921-03-7 | TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
| CSN16748 | (5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one | 518-28-5 | Podophyllotoxin is a competitive microtubule assembly inhibitor. |
| CSN13791 | Plinabulin | 714272-27-2 | Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. |
| CSN17857 | PF-0638101 | 1436391-86-4 | PF-06380101 is a cytotoxic Dolastatin 10 analogue and with excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs. |
| CSN17814 | MMAF Hydrochloride | 1415246-68-2 | MMAF HCl is an antitubulin agent that inhibit cell division. It inhibits H3397 cell growth with an IC50 of 105 nM. |
| CSN13727 | Monomethyl Auristatin F | 745017-94-1 | MMAF can inhibit tubulin polymerization used in ADCs, with lower cytotoxic activity than MMAE. |
| CSN18091 | Monomethyl Auristatin D | 203849-91-6 | MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| CSN18492 | Mc-MMAE | 863971-24-8 | Mc-MMAE is a protective group (maleimidocaproyl)-conjugated MMAE. |
| CSN17792 | Mc-MMAD | 1401963-15-2 | Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. |
| CSN19821 | Maytansine | 35846-53-8 | Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. |
| CSN17189 | (S)-1-Ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea | 917111-44-5 | Lexibulin can potently inhibit microtubule polymerization with vascular-disrupting, and potential antineoplastic activities. |
| CSN18573 | Lexibulin 2HCl | 917111-49-0 | Lexibulin 2HCl is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines and with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
| CSN17257 | Leucomethylene blue mesylate | 1236208-20-0 | Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
| CSN18117 | Ixabepilone | 219989-84-1 | Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization. |
| CSN19198 | INH6 | 1001753-24-7 | INH6 can bind to Hec1 and inhibit its association with Nek2 and kinetochores. |
| CSN16575 | INH1 | 313553-47-8 | INH1 is a Hec1 inhibitor which can cause arrest of mitosis. |
| CSN16859 | Estramustine phosphate sodium | 52205-73-9 | Estramustine phosphate sodium is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle. |
| CSN18160 | Eribulin | 253128-41-5 | Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules. |
| CSN18275 | Eribulin Mesylate | 441045-17-6 | Eribulin mesylate, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules. |
| CSN15734 | Epothilone D | 189453-10-9 | Epothilone D is a potent microtubule stabilizer. |
| CSN18805 | Epothilone A | 152044-53-6 | Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM. |
| CSN16317 | ELR510444 | 1233948-35-0 | ELR510444 is an inhibitor of tubulin polymerization with IC50 value of 10 μM. |
| CSN17468 | Dolastatin 10 | 110417-88-4 | Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE) |
| CSN16704 | Docetaxel Trihydrate | 148408-66-6 | Docetaxel Trihydrate can promote the assembly of microtublules. |
| CSN14353 | Deoxypodophyllotoxin | 19186-35-7 | Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction. |
| CSN18416 | D-64131 | 74588-78-6 | D-64131 is a novel tubulin polymerization inhibitor working by competitively binding with colchicine to αβ-tubulin. |
| CSN18882 | Cys-mcMMAD | N/A | Cys-mcMMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| CSN18469 | Cevipabulin | 849550-05-6 | Cevipabulin is a potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer. |
| CSN18622 | BNC105 | 945771-74-4 | BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. |
| CSN18933 | Soblidotin | 149606-27-9 | Auristatin PE is a synthetic Dolastatin 10 derivative and inhibitor oftubulinpolymerization. |
| CSN17976 | Auristatin F | 163768-50-1 | Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates. |
| CSN17946 | Auristatin E | 160800-57-7 | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity and it is an MMAE analog and cytotoxin in Antibody-drug conjugates. |
| CSN18377 | Ansamitocin P-3 | 66584-72-3 | Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. |
| CSN16395 | Methyl (5-(propylthio)-1H-benzo[d]imidazol-2-yl)carbamate | 54965-21-8 | Albendazole is a microtubule depolymerizing agent which can affect tubulin dynamics. |
| CSN16987 | ABT-751 | 141430-65-1 | ABT-751 can inhibit microtubule polymerization through binding to β-tubulin on the colchine site. |
| CSN16777 | 4'-Demethylepipodophyllotoxin | 6559-91-7 | 4'-Demethylepipodophyllotoxin is a potent microtubule assembly inhibitor, acting as an antimitotic agent. |
| CSN50115 | 15-Oxospiramilactone | 1053172-87-4 |
