MK2 is a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo.
|CSN15896||PF-3644022||1276121-88-0||PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.|
|CSN17686||MK2-IN-1||1314118-92-7||MK2-IN-1 is a potent and selecitve MAPKAPK2 (MK2) inhibitor (IC50=0.11 μM) with a non-ATP competitive binding mode.|
|CSN17687||MK2-IN-1 hydrochloride||1314118-94-9||MK2-IN-1 HCl is a non-ATP competitive inhibitor of MAPKAPK2 (MK2) with IC50 of 0.11 μM.|
|CSN28422||MK2-IN-3||724711-21-1||MK2 Inhibitor III is a potent and selective MK-2 inhibitor with IC50 value of 8.5nM.|
|CSN15865||BMS-754807||1001350-96-4||BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc.|