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Myosin light-chain kinase also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates a specific myosin light chain, namely, the regulatory light chain of myosin II.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22980 | MLCK Inhibitor Peptide 18 | 224579-74-2 | MLCK Inhibitor Peptide 18 is a selective competitive inhibitor of myosin light chain kinase with IC50 of 50 nM. |
| CSN12294 | ML-7 HCl | 110448-33-4 | ML-7 HCl is a multiple-target inhibitor of MLCK with Ki value of 300 nM, PKA with 21μM, and PKC of 42 μM. |
| CSN23710 | ML-9 | 105637-50-1 | ML 9 a is myosin light chain kinase (MLCK) inhibitor. ML-9 enhances the anticancer activity of docetaxel, suggesting its potential application as an adjuvant to existing anticancer chemotherapy. The complex effect of ML-9 on autophagy and indentified ML-9 as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy. |
| CSN26207 | 5-(Piperazin-1-ylsulfonyl)isoquinoline | 84468-24-6 | HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase (IC50 values are 4, 8, 12 and 240 μM, respectively). |
| CSN10984 | Fasudil HCl | 105628-07-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN33153 | W-7 HCl | 61714-27-0 | Calmodulin antagonist. Inhibits myosin light chain kinase |
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