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mTOR

mTOR

货号 产品名 CAS号 信息
CSN15943 Zotarolimus 221877-54-9 Zotarolimus is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.
CSN17119 XL388 1251156-08-7 XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 9.9 nM.
CSN16762 WYE-687 1062161-90-3 WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM showing > 100 fold selectivity for mTOR than PI3Kα/γ.
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K (T389) and mTORC2/P-AKT (S473) not P-AKT (T308), selective for mTOR than PI3Kα (> 100-fold) and PI3Kγ (> 500-fold).
CSN15879 WYE-132 1144068-46-1 WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM, highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
CSN16670 WAY-600 1062159-35-6 WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM and blocks mTORC1/P-S6K (T389) and mTORC2/P-AKT (S473) but not P-AKT (T308). It is selective for mTOR than PI3Kα (> 100-fold) and PI3Kγ (> 500-fold).
CSN13765 Ridaforolimus 572924-54-0 Treatment of HT-1080 cells with Deforolimus induces a dose-dependent inhibition of phosphorylation of both S6 and 4E-BP1, with IC50 of 0.2 nM and 5.6 nM, respectively, and leads to a decrease in cell size, an increase in the proportion of cells in the G1 phase of the cell cycle, and inhibition of glucose uptake.
CSN15687 Torin 2 1223001-51-1 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM, showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
CSN17146 Torin 1   1222998-36-8 Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM exhibiting 1000-fold selectivity for mTOR than PI3K.
CSN12047 Temsirolimus 162635-04-3 Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM.
CSN26152 SAFit2 1643125-33-0 SAFit2 is a novel selective antagonist of the FK506-binding protein 51 with Ki value of 6nM.
CSN16385 Rapamycin 53123-88-9 Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM.
CSN21086 RapaLink-1 1887095-82-0 RapaLink-1 is the third-generation mTOR inhibitor exploiting the unique juxtaposition of two drug (first- and second-generation mTOR kinase inhibitors) –binding pockets to create a bivalent interaction that allows inhibition of the mutants which has resistance to the previous TORKi (mTOR kinase inhibitors).
CSN17584 QL-IX-55 1223002-54-7 QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.
CSN23791 PWT33597 mesylate 1246203-36-0 PWT33597 is a dual inhibitor of PI3K alpha and mTOR with selectivity for PI3K alpha (IC50 = 26 nM) over PI3K delta (IC50 = 291 nM) but also displaying activity against mTOR in biochemical assays (IC50 = 21 nM). It had good pharmacokinetic properties in multiple preclinical species.
CSN19143 PQR620 1927857-56-4 PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo.
CSN12732 Torkinib 1092351-67-1 PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM.
CSN13796 Palomid 529 914913-88-5 Palomid 529 is a novel dual mTORC1/2 inhibitor.
CSN16065 OSI-027 936890-98-1 OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
CSN11574 Nordihydroguaiaretic acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor.
CSN27361 Niclosamide olamine 1420-04-8 Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
CSN17562 mTOR inhibitor-3 1207358-59-5 mTOR-IN-1 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 1.5 nM.
CSN27773 mTOR inhibitor-1   468747-17-3 mTOR inhibitor-1 is an ATP-competitive inhibitor of mTOR. It suppressed A549 cell proliferation and induced autophagy.
CSN16980 MHY1485 326914-06-1 MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.
CSN17919 LY 303511 154447-38-8 LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.
CSN19147 LY 303511 hydrochloride 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K, but not PI3K-dependent phosphorylation of Akt. It also blocks voltage-gated potassium (Kv) channels with IC50 value of 64.6 μM.
CSN25185 L-Leucine 61-90-5 Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels growth and repair of muscle and bone tissue growth hormone production and wound healing.
CSN12392 KU-0063794 938440-64-3 KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively) with no effect on PI3Ks.
CSN15888 Sapanisertib 1224844-38-5 INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM and is > 200-fold less potent to class I PI3K isoforms.
CSN17116 GDC-0349 1207360-89-1 GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, showing > 700-fold selectivity over PI3Kα and other 266 kinases.
CSN22228 FT-1518 1313026-58-2 FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.
CSN16716 Everolimus 159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN15905 ETP-46464 1345675-02-6 ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).
CSN19142 CZ415 1429639-50-8 CZ415 is a potent and highly selective ATP-competitive mTOR inhibitor with pKdapp value of 8.2.
CSN17593 Onatasertib 1228013-30-6 CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with > 150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM).
CSN26528 BGT226 915020-55-2 BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.
CSN12949 AZD-8055 1009298-09-2 AZD8055 is an ATP-competitive mTOR inhibitor with IC50 of 0.8 nM with excellent selectivity (～1,000-fold) against PI3K isoforms and ATM/DNA-PK.
CSN13850 Vistusertib 1009298-59-2 AZD2014 is an mTOR inhibitor with IC50 of 2.8 nM and is highly selective against multiple PI3K isoforms (α/β/γ/δ).
CSN22703 AZD3147 1101810-02-9 AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor with IC50 of 1.5 nM.
CSN18074 AP20187 195514-80-8 AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.
CSN18073 Rimiducid 195514-63-7 AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM.
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
CSN51382 MTI-31 1567915-38-1
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