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mTOR

mTOR

货号 产品名 CAS号 信息
CSN17119 XL388 1251156-08-7 XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 9.9 nM.
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K (T389) and mTORC2/P-AKT (S473) not P-AKT (T308), selective for mTOR than PI3Kα (> 100-fold) and PI3Kγ (> 500-fold).
CSN15687 Torin 2 1223001-51-1 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM, showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
CSN17146 Torin 1   1222998-36-8 Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM exhibiting 1000-fold selectivity for mTOR than PI3K.
CSN12047 Temsirolimus 162635-04-3 Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM.
CSN15684 Tacrolimus 104987-11-3 Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12).
CSN12789 Tacrolimus Monohydrate 109581-93-3 Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12).
CSN16385 Rapamycin 53123-88-9 Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM.
CSN11574 Nordihydroguaiaretic Acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor.
CSN27361 Niclosamide olamine 1420-04-8 Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
CSN16980 MHY1485 326914-06-1 MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.
CSN17919 LY303511 154447-38-8 LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.
CSN19147 LY303511 HCl 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K, but not PI3K-dependent phosphorylation of Akt. It also blocks voltage-gated potassium (Kv) channels with IC50 value of 64.6 μM.
CSN16716 Everolimus 159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN18074 AP20187 195514-80-8 AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.
CSN18073 AP1903 195514-63-7 AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM.
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
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