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mTOR

mTOR

货号 产品名 CAS号 信息
CSN15943 Zotarolimus 221877-54-9 Zotarolimus is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.
CSN17119 XL388 1251156-08-7 XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 9.9 nM.
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K (T389) and mTORC2/P-AKT (S473) not P-AKT (T308), selective for mTOR than PI3Kα (> 100-fold) and PI3Kγ (> 500-fold).
CSN12047 Temsirolimus 162635-04-3 Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM.
CSN16385 Rapamycin 53123-88-9 Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM.
CSN11574 Nordihydroguaiaretic Acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor.
CSN27361 Niclosamide olamine 1420-04-8 Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
CSN27773 mTOR inhibitor-1   468747-17-3 mTOR inhibitor-1 is an ATP-competitive inhibitor of mTOR. It suppressed A549 cell proliferation and induced autophagy.
CSN16980 MHY1485 326914-06-1 MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.
CSN17919 LY303511 154447-38-8 LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.
CSN19147 LY303511 HCl 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K, but not PI3K-dependent phosphorylation of Akt. It also blocks voltage-gated potassium (Kv) channels with IC50 value of 64.6 μM.
CSN25185 L-Leucine 61-90-5 Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels growth and repair of muscle and bone tissue growth hormone production and wound healing.
CSN16716 Everolimus 159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN15905 ETP-46464 1345675-02-6 ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).
CSN18074 AP20187 195514-80-8 AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.
CSN18073 AP1903 195514-63-7 AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM.
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
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