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mTOR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17119 | XL388 | 1251156-08-7 | XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 9.9 nM. |
| CSN16829 | WYE-354 | 1062169-56-5 | WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K (T389) and mTORC2/P-AKT (S473) not P-AKT (T308), selective for mTOR than PI3Kα (> 100-fold) and PI3Kγ (> 500-fold). |
| CSN15687 | Torin 2 | 1223001-51-1 | Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM, showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively. |
| CSN17146 | Torin 1 | 1222998-36-8 | Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM exhibiting 1000-fold selectivity for mTOR than PI3K. |
| CSN12047 | Temsirolimus | 162635-04-3 | Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM. |
| CSN15684 | Tacrolimus | 104987-11-3 | Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). |
| CSN12789 | Tacrolimus Monohydrate | 109581-93-3 | Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). |
| CSN16385 | Rapamycin | 53123-88-9 | Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM. |
| CSN11574 | Nordihydroguaiaretic Acid | 500-38-9 | Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor. |
| CSN27361 | Niclosamide olamine | 1420-04-8 | Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling. |
| CSN16980 | MHY1485 | 326914-06-1 | MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. |
| CSN17919 | LY303511 | 154447-38-8 | LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. |
| CSN19147 | LY303511 HCl | 2070014-90-1 | LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K, but not PI3K-dependent phosphorylation of Akt. It also blocks voltage-gated potassium (Kv) channels with IC50 value of 64.6 μM. |
| CSN16716 | Everolimus | 159351-69-6 | Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
| CSN16716 | Everolimus | 159351-69-6 | Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
| CSN18074 | AP20187 | 195514-80-8 | AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain. |
| CSN18073 | AP1903 | 195514-63-7 | AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM. |
| CSN23318 | 3BDO | 890405-51-3 | 3BDO is a new mTOR activator which can also inhibit autophagy. |