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Neurological Disease

货号 产品名 CAS号 信息
CSN22437 JNJ-46778212 1363281-27-9 JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
CSN22497 RO 4938581 883093-10-5 RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
CSN22348 AP521 151227-08-6 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
CSN22241 NBQX 118876-58-7 NBQX is a potent, selective and competitive AMPAR antagonist, which shows activity of neuroprotective and anticonvulsant.
CSN22445 L-AP4 23052-81-5 L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13±0.02, 0.29±0.07, 1.0±0.3, 249±107 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
CSN22913 MMPEP 823198-78-3 MPEP HCl is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM, and a mGlu4 receptor positive allosteric modulator.
CSN22504 Serlopitant 860642-69-9 Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
CSN22458 MARK-IN-1 1109283-93-3 MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM.
CSN22503 Saredutant 142001-63-6 Saredutant is a selective NK2 receptor antagonist.
CSN22144 PF 04531083 1079400-07-9 PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain
CSN22530 Ubrogepant 1374248-77-7 Ubrogepant is an oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine.
CSN22190 5-HT4 antagonist 1 261766-73-8 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
CSN22173 CE-224535 724424-43-5 CE-224535 is a selective P2X7 receptor antagonist.
CSN22192 AR-A 2 220051-79-6 AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki=5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.
CSN22199 GNE 5729 2026635-66-3 GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
CSN22177 Sodium Channel inhibitor 2 653573-60-5 Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c.
CSN22166 Emicerfont 786701-13-1 Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.
CSN22197 CX-157 205187-53-7 CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.
CSN22242 Antihistamine-1 1186430-60-3 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
CSN22216 NS1652 1566-81-0 NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.
CSN22229 BACE1-IN-1 1310347-50-2 BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
CSN22325 Buntanetap 116839-68-0 Posiphen is a selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.
CSN22349 Apimostinel 1421866-48-9 Apimostinel is an oral NMDA receptor partial agonist.
CSN22373 CGRP antagonist 1 1123757-49-2 CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.
CSN22331 5-HT7 agonist 1 334974-31-1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders.
CSN22354 AZD-8529 1092453-15-0 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
CSN22355 Balovaptan 1228088-30-9 Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
CSN22401 Fluxametamide 928783-29-3 Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95  nM and 225  nM for M. domestica GABACls and GluCls.
CSN22345 AMG 579 1227067-61-9 AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
CSN22323 (+)-Dihydrexidine hydrochloride 158704-02-0 (+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy.
CSN22346 AMPD2 inhibitor 1 2139356-35-5 AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.
CSN22416 Glutaminyl Cyclase Inhibitor 2 1884546-29-5 Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC50 of 1.23 μM.
CSN22417 GNE-0723 1883518-31-7 GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.
CSN22440 JYL 1421 401907-26-4 JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM.
CSN22487 PF-4778574 1219633-99-4 PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
CSN22452 LY 344864 hydrochloride 1217756-94-9 LY 344864 HCl is a selective 5-HT1F agonist with a Ki of 6 nM.
CSN22464 Ibodutant 522664-63-7 MEN 15596 is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1.
CSN22459 MARK-IN-2 1314893-26-9 MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM.
CSN22465 MIV-247 1352817-76-5 MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
CSN22469 MSOP 66515-29-5 MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
CSN22529 UBP 1112 339526-74-8 UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM, 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor.
CSN22520 TMP778 1422171-08-1 TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.
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