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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22437 | JNJ-46778212 | 1363281-27-9 | JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. |
| CSN22348 | AP521 | 151227-08-6 | AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. |
| CSN22241 | NBQX | 118876-58-7 | NBQX is a potent, selective and competitive AMPAR antagonist, which shows activity of neuroprotective and anticonvulsant. |
| CSN22445 | L-AP4 | 23052-81-5 | L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13±0.02, 0.29±0.07, 1.0±0.3, 249±107 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. |
| CSN22913 | MMPEP | 823198-78-3 | MPEP HCl is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM, and a mGlu4 receptor positive allosteric modulator. |
| CSN22504 | Serlopitant | 860642-69-9 | Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist. |
| CSN22458 | MARK-IN-1 | 1109283-93-3 | MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM. |
| CSN22503 | Saredutant | 142001-63-6 | Saredutant is a selective NK2 receptor antagonist. |
| CSN22144 | PF 04531083 | 1079400-07-9 | PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain |
| CSN22530 | Ubrogepant | 1374248-77-7 | Ubrogepant is an oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine. |
| CSN22190 | 5-HT4 antagonist 1 | 261766-73-8 | 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. |
| CSN22173 | CE-224535 | 724424-43-5 | CE-224535 is a selective P2X7 receptor antagonist. |
| CSN22192 | AR-A 2 | 220051-79-6 | AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki=5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety. |
| CSN22199 | GNE 5729 | 2026635-66-3 | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
| CSN22177 | Sodium Channel inhibitor 2 | 653573-60-5 | Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c. |
| CSN22166 | Emicerfont | 786701-13-1 | Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM. |
| CSN22197 | CX-157 | 205187-53-7 | CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. |
| CSN22242 | Antihistamine-1 | 1186430-60-3 | Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. |
| CSN22216 | NS1652 | 1566-81-0 | NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. |
| CSN22229 | BACE1-IN-1 | 1310347-50-2 | BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. |
| CSN22325 | Buntanetap | 116839-68-0 | Posiphen is a selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM. |
| CSN22349 | Apimostinel | 1421866-48-9 | Apimostinel is an oral NMDA receptor partial agonist. |
| CSN22373 | CGRP antagonist 1 | 1123757-49-2 | CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively. |
| CSN22331 | 5-HT7 agonist 1 | 334974-31-1 | 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders. |
| CSN22354 | AZD-8529 | 1092453-15-0 | AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
| CSN22355 | Balovaptan | 1228088-30-9 | Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism. |
| CSN22401 | Fluxametamide | 928783-29-3 | Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls. |
| CSN22345 | AMG 579 | 1227067-61-9 | AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. |
| CSN22323 | (+)-Dihydrexidine hydrochloride | 158704-02-0 | (+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM. |
| CSN22403 | Fonadelpar | 515138-06-4 | Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. |
| CSN22346 | AMPD2 inhibitor 1 | 2139356-35-5 | AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions. |
| CSN22416 | Glutaminyl Cyclase Inhibitor 2 | 1884546-29-5 | Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC50 of 1.23 μM. |
| CSN22417 | GNE-0723 | 1883518-31-7 | GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. |
| CSN22440 | JYL 1421 | 401907-26-4 | JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM. |
| CSN22487 | PF-4778574 | 1219633-99-4 | PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. |
| CSN22452 | LY 344864 hydrochloride | 1217756-94-9 | LY 344864 HCl is a selective 5-HT1F agonist with a Ki of 6 nM. |
| CSN22464 | Ibodutant | 522664-63-7 | MEN 15596 is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1. |
| CSN22459 | MARK-IN-2 | 1314893-26-9 | MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM. |
| CSN22465 | MIV-247 | 1352817-76-5 | MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively. |
| CSN22469 | MSOP | 66515-29-5 | MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR. |
| CSN22529 | 2-Amino-2-(3-methyl-4-phosphonophenyl)propanoic acid | 339526-74-8 | UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM, 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor. |
| CSN22520 | TMP778 | 1422171-08-1 | TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. |
