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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22437 | JNJ-46778212 | 1363281-27-9 | JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. |
| CSN22348 | AP521 | 151227-08-6 | AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. |
| CSN22241 | NBQX | 118876-58-7 | NBQX is a potent, selective and competitive AMPAR antagonist, which shows activity of neuroprotective and anticonvulsant. |
| CSN22445 | L-APB | 23052-81-5 | L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13±0.02, 0.29±0.07, 1.0±0.3, 249±107 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. |
| CSN22913 | MMPEP | 823198-78-3 | MPEP HCl is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM, and a mGlu4 receptor positive allosteric modulator. |
| CSN22190 | 5-HT4 Antagonist 1 | 261766-73-8 | 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. |
| CSN22192 | AR-A 2 | 220051-79-6 | AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki=5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety. |
| CSN22197 | CX157 | 205187-53-7 | CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. |
| CSN22242 | Antihistamine-1 | 1186430-60-3 | Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. |
| CSN22216 | NS1652 | 1566-81-0 | NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. |
| CSN22325 | (+)-Phenserine | 116839-68-0 | Posiphen is a selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM. |
| CSN22373 | CGRP Antagonist 1 | 1123757-49-2 | CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively. |
| CSN22331 | 5-HT7 Agonist 1 | 334974-31-1 | 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders. |
| CSN22323 | (+)-Dihydrexidine HCl | 158704-02-0 | (+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM. |
| CSN22403 | Fonadelpar | 515138-06-4 | Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. |
| CSN22469 | MSOP | 66515-29-5 | MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR. |
