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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN18277 | Vipadenant | 442908-10-3 | Vipadenant is an adenosine antagonist with Ki of 1.3 nM and 68 nM for A2A and A1, respectively. Vipadenant is a selective A2A receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, used in development for for Parkinson's disease. |
CSN18285 | Idalopirdine HCl | 467458-02-2 | Lu AE58054 HCl is an anti-Alzheimer's agent with serotonin 5-HT6 receptor antagonist effect Ki value of 0.83 nM. |
CSN18338 | Etifoxine HCl | 56776-32-0 | Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects. |
CSN18546 | A 438079 HCl | 899431-18-6 | A 438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). |
CSN18554 | Pitolisant HCl | 903576-44-3 | Pitolisant HCl is an inverse agonist of human H3 receptor with Ki of 0.16 nM. |
CSN18575 | Lorediplon | 917393-39-6 | Lorediplon, non-benzodiazepine hypnotic drug, acts as a modulator of GABAA receptor with the effect of promoting sleep. |
CSN18640 | A-836339 | 959746-77-1 | A-836339 is a cannabinoid CB2 receptor-selective agonist and exhibits high potencies at CB(2) and selectivity over CB(1) receptors. |
CSN18662 | N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride | 2508-72-7 | Antazoline HCl is a antihistamine with anticholinergic properties. It is used to relieve nasal congestion. |
CSN18291 | A-317491 | 475205-49-3 | A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors. |
CSN18381 | LDN-57444 | 668467-91-2 | LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM). |
CSN18582 | Opicapone | 923287-50-7 | Opicapone is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase. |
CSN18592 | Milnacipran | 92623-85-3 | Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. |
CSN18415 | SKF-82958 hydrobromide | 74115-01-8 | SKF-82958 hydrobromide is a D1/D5 receptor full agonist. |
CSN18418 | PRE-084 HCl | 75136-54-8 | PRE-084 HCl is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay. |
CSN18619 | SMER18 | 944153-47-3 | SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer. |
CSN18386 | K 01-162 | 677746-25-7 | K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. |
CSN18594 | Bavisant | 929622-08-2 | Bavisant is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. |
CSN18420 | Moxonidine HCl | 75536-04-8 | Moxonidine HCl is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. |
CSN18441 | 4-Amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride | 81342-13-4 | Amisulpride HCl is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor). |
CSN18395 | BoNT-IN-1 | 694443-03-3 | BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A light chain (BoNTA LC) with IC50 of 0.9 μM. |
CSN18595 | Bavisant dihydrochloride | 929622-09-3 | Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. |
CSN18457 | GSK163090 | 844903-58-8 | GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for dopamine D2/D3, respectively. |
CSN18296 | CIQ | 486427-17-2 | CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. |
CSN18318 | Methoxy-PEPy | 524924-76-3 | Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. |
CSN18653 | Telotristat | 1033805-28-5 | Telotristat is an active metabolite of LX1606, which is an inhibitor of tryptophan hydroxylase. |
CSN18262 | Amitifadine hydrochloride | 410074-74-7 | Amitifadine HCl is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
CSN18378 | 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride | 666179-74-4 | Risperidone HCl is a serotonin 5-HT2 receptor blocker (Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist (Ki= 1.4 nM). |
CSN18667 | GSK-2881078 | 1539314-06-1 | GSK 2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia. |
CSN18390 | Zonisamide sodium | 68291-98-5 | Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. |
CSN18631 | N-[(4-Aminophenyl)methyl]adenosine | 95523-13-0 | N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor, with Ki of 29 nM for rat ecto-5′-nucleotidase. |
CSN18512 | Dipraglurant | 872363-17-2 | Dipraglurant is a mGluR5 antagonists with IC50 of 0.021 μM. |
CSN18450 | Agomelatine (L(+)-Tartaric acid) | 824393-18-2 | Agomelatine L(+)-tartaric acid is an antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
CSN18624 | RN-1734 | 946387-07-1 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). |
CSN18286 | Idalopirdine | 467459-31-0 | Lu AE58054 is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM. |
CSN18379 | Risperidone mesylate | 666179-96-0 | Risperidone mesylate is a serotonin 5-HT2 receptor blocker (Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist (Ki= 1.4 nM). |
CSN18541 | APNEA | 89705-21-5 | N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, non-selective A3 adenosine receptor agonist. |
CSN18478 | Setiptiline maleate | 85650-57-3 | Setiptiline is a serotonin receptor antagonist. |
CSN18439 | Notoginsenoside R2 | 80418-25-3 | Notoginsenoside R2 is a notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis. |
CSN18659 | Lanabecestat | 1383982-64-6 | AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
CSN18672 | CGS-9896 | 77779-36-3 | CGS-9896 is an anxiolytic drug used in scientific research. |
CSN18253 | Tarafenacin | 385367-47-5 | Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. |
CSN18368 | Azaphen 2HCl | 63302-99-8 | Pipofezine is a potent inhibitor of the reuptake of serotonin. |
CSN18435 | JDTic 2HCl | 785835-79-2 | JDTic 2HCl is a highly selective antagonist for the κ-opioid receptor without affecting the μ- or δ-opioid receptors. |
CSN18547 | A 438079 | 899507-36-9 | A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). |
CSN18509 | A 839977 | 870061-27-1 | A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). |
CSN18536 | LDN-212320 | 894002-50-7 | LDN-212320 is a glutamate transporter EAAT2 activator and enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h. |
CSN18608 | gamma-Secretase Modulators | 937812-80-1 | gamma-Secretase modulators is an Amyloid-β production inhibitor, useful for Alzheimer's disease. |
CSN18369 | N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide xmaleate | 634908-75-1 | WAY-100635 Maleate is both a potent and silent antagonist of 5-HT1A receptors with IC50 value of 2.2 nM and an agonist of dopamine D4 receptors. |