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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17915 | rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride hydrate (2:2:1) | 153504-70-2 | Cevimeline HCl, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. |
| CSN17942 | N,N'-(trans-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) | 1597403-47-8 | ISRIB is a potent inhibitor of PERK signaling showing inhibition of the ATF4 luciferase reporter in HEK293T cells with IC50 of 5 nM. |
| CSN18041 | JNJ-63533054 | 1802326-66-4 | JNJ-63533054 is a selective hGPR139 agonist with EC50 of 16 nM. |
| CSN18143 | IQ-1S free acid | 23146-22-7 | IQ-1S Free Acid is a selective JNK3 inhibitor with IC50 value of 87 nM, with less potency against JNK 1/2 with IC50 values of 390/360nM. |
| CSN18166 | Minaprine | 25905-77-5 | Minaprine is a reversible inhibitor of MAO-A, a weak inhibitor acetylcholinesterase, and an antidepressant for treatment of depression. |
| CSN17916 | GNE-9605 | 1536200-31-3 | GNE-9605 is a selective and potent LRRK2 with IC50 value of 18.7 nM. |
| CSN18136 | Emapunil | 226954-04-7 | Emapunil is a ligand of translocator protein TSPO (18 kDa) with Ki of 0.297 nM. It can enhance GABA-mediated neurotransmission via induction of neurosteroidogenesis and has antidepressant effect. |
| CSN18036 | Orexin 2 Receptor Agonist | 1796565-52-0 | Orexin 2 receptor agonist is a potent and selective OX2R agonist with EC50 of 23 nM. |
| CSN17988 | 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine | 165377-43-5 | SA4503 is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM. |
| CSN18220 | Chembridge-5861528 | 332117-28-9 | Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). |
| CSN18197 | GW791343 3HCl | 309712-55-8 | GW791343 3HCl is a P2X7 allosteric modulator and exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). |
| CSN18007 | Trans (2,3)-Dihydrotetrabenazine | 171598-74-6 | NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication. |
| CSN18101 | LY-411575 isomer 1 | 209984-58-7 | LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM. |
| CSN18174 | Pardoprunox | 269718-84-5 | Pardoprunox is a partial dopamine D2 (pKi = 8.1) and D3 (pKi = 8.6) receptor agonist (IA = 50% and 67%, respectively) and full serotonin 5-HT1A (pKi = 8.5) receptor agonist (IA = 100%), and also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity. |
| CSN18056 | Ginsenoside Rg5 | 186763-78-0 | Ginsenoside Rg5 is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. showing anti-inflammatory effect. |
| CSN17953 | Fanapanel | 161605-73-8 | ZK200775 is a highly selective AMPA/kainate antagonist with little activity against NMDA with Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| CSN17819 | ST-836 hydrochloride | 1415564-68-9 | ST-836 HCl is a dopamine receptor ligand which act as an antiparkinsonian agent. |
| CSN18008 | Fosaprepitant | 172673-20-0 | Fosaprepitant is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. |
| CSN17887 | Maropitant | 147116-67-4 | Maropitant is a neurokinin (NK1) receptor antagonist. |
| CSN18229 | AS601245 | 345987-15-7 | AS-601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK) (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM), has neuroprotective properties. |
| CSN18085 | (S)-Rasagiline mesylate | 202464-88-8 | TVP1022 mesylate is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. |
| CSN18033 | SDZ 220-581 HCl | 179411-93-9 | SDZ 220-581 HCl is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| CSN17912 | ML355 | 1532593-30-8 | ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 µM, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM). |
| CSN18110 | SB269652 | 215802-15-6 | SB-269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R) and a chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology. |
| CSN17909 | Ab-meca | 152918-26-8 | AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors. |
| CSN17982 | (6AR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one phosphate | 1642303-38-5 | ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). |
| CSN17813 | PEPA | 141286-78-4 | PEPA is an allosteric modulator of AMPA receptors and binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. |
| CSN18034 | SDZ 220-581 Ammonium salt | 179411-94-0 | SDZ 220-581 ammonium is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| CSN18042 | Solifenacin HCl | 180468-39-7 | Solifenacin HCl is a muscarinic receptor antagonist. |
| CSN17880 | Suramin | 145-63-1 | Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM). |
| CSN17843 | gamma-secretase modulator 3 | 1431697-84-5 | gamma-Secretase modulator 3 is a gamma-secretase modulator. |
| CSN17884 | UPF-648 sodium salt | 1465017-87-1 | UPF-648 sodium is a potent kynurenine 3-monooxygenase (KMO) inhibitor, exhibits highly active at 1 μM(81 ± 10% KMO inhibition), and is ineffective at blocking KAT activity. |
| CSN18094 | Talnetant HCl | 204519-66-4 | Talnetant HCl is a potent and selective NK3 receptor antagonist (ki=1.4 nM, hNK-3-CHO), 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 μM. |
| CSN17812 | Asenapine HCl | 1412458-61-7 | Asenapine HCl inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM. |
| CSN18004 | Imidafenacin | 170105-16-5 | Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM and less potent for M2 receptors (IC50=4.13 nM). |
| CSN18100 | SB 271046 HCl | 209481-24-3 | SB-271046 HCl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. |
| CSN18242 | Pitolisant oxalate | 362665-57-4 | Pitolisant oxalate is a potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM). |
| CSN17847 | SB-408124 HCl | 1431697-90-3 | SB-408124 HCl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively and exhibits 50-fold selectivity over OX2 receptor. |
| CSN17874 | ML314 | 1448895-09-7 | ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM) and shows good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. |
| CSN17905 | 4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one hydrochloride | 1511-16-6 | Haloperidol HCl blocks dopamine receptors in in the treatment of schizophrenia, acute psychosis, and delirium. |
| CSN17930 | Rivanicline | 15585-43-0 | RJR-2403 is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM) showing > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM). |
| CSN18026 | NKP608 | 177707-12-9 | NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro (IC50=2.6 nM) and in vivo. |
| CSN18000 | Reserpine HCl | 16994-56-2 | Reserpine HCl is a naturally occuring brain-penetrant and irreversible VMAT (vesicular monoamine transporter 1 and 2) antagonist. |
| CSN18049 | Ciproxifan | 184025-18-1 | Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
| CSN18122 | Rivanicline oxalate | 220662-95-3 | RJR-2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM), showing > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM). |
| CSN18125 | Adoprazine | 222551-17-9 | Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. |
