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Neurological Disease

货号 产品名 CAS号 信息
CSN17026 (R)-4-Amino-3-(4-chlorophenyl)butanoic acid 69308-37-8 (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity.
CSN17031 (S)-2-(4-Isobutylphenyl)propanoic acid 51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN17059 Pralidoxime chloride 51-15-0 Pralidoxime chloride is an AChE reactivator, used as an antidote to organophosphate pesticides and chemicals.
CSN17080 Betahistine 2HCl 5579-84-0 Betahistine 2HCl is histamine H3 receptor inhibitor with IC50 of 1.9 μM. It is an antivertigo drug.
CSN17089 Bemegride 64-65-3 Bemegride can stimulate central nervous system and release barbiturate poisoning.
CSN17129 JH-II-127 1700693-08-8 JH-II-127 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively.
CSN17132 LY-411575 209984-57-6 LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM).
CSN17194 N-Benzyl-4-chloro-N-cyclohexylbenzamide 945714-67-0 FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells.
CSN17228 Milnacipran ((1S-cis) HCl) 175131-60-9 (1S-cis)-Milnacipran HCl inhibits serotonin-norepinephrine reuptake and is used for the treatment of fibromyalgia.
CSN17246 Azeliragon 603148-36-3 Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE) with Kd of 12.7 nM for human recombinant sRAGE. While RAGE transports amyloid-β (Aβ) from plasma into the CNS, Azeliragon is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD).
CSN17267 Atipamezole HCl 104075-48-1 Atipamezole HCl is a competitive α2-adrenergic receptor antagonist, mainly used in veterinary medicine.
CSN17271 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine HCl 23007-85-4 MPTP HCl is a neurotoxin that causes symptoms similar to parkinson's disease by destroying dopamine-producing nerve cells in the substantia nigra. It is widely used in the study of various animal models of Parkinson's disease.
CSN17302 SMER28 307538-42-7 SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of the mTOR pathway.
CSN17328 ACY-738 1375465-91-0 ACY-738 inhibits HDAC6 with IC50 value of 1.7 nM.
CSN17333 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride 969-33-5 Cycloheptadine HCl is a 5-HT2A receptor antagonist which can inhibit serotonin-enhanced platelet function.
CSN17367 N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide 1215493-56-3 RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
CSN17058 Tetrahydropapaverine HCl 6429-04-5 Tetrahydropapaverine HCl is a papaverine-derived inhibitor of TPH with the IC50 value of 5.7 μM.
CSN17033 (S)-Rasagiline 185517-74-2 TVP1022 is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.
CSN17054 GBR 12935 2HCl 67469-81-2 GBR 12935 2HCl is a potent and selective dopamine reuptake inhibitor with KD of 5.5 nM in rat striatal membranes.
CSN17284 L-685458 292632-98-5 L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM.
CSN17134 LY2886721 1262036-50-9 LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
CSN17052 (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide 130929-57-6 Entacapone is a specific, potent and peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.
CSN17060 RU 24969 66611-26-5 RU 24969 is a selective agonist of the 5-HT1A and 5-HT1B receptors.
CSN17247 TG6-10-1 1415716-58-3 TG6-10-1 is an antagonist of prostaglandin E2 receptor subtype EP2.
CSN17015 E 2012 870843-42-8 E 2012 is a potent γ-secretase modulator.
CSN17108 2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione hydrobromide 115338-32-4 NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist.
CSN103350 2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione hydrobromide 115338-32-4
CSN16971 Cariprazine HCl 1083076-69-0 Cariprazine HCl is an antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3 (Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors.
CSN17029 (S)-(-)-5-Fluorowillardiine 140187-23-1 (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.
CSN17061 SKF89976A HCl 85375-15-1 SKF-89976A HCl is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.
CSN17275 Naspm 3HCl 1049731-36-3 Naspm 3HCl is a potent and selective Ca2+ permeable AMPA receptor (Ca-perm AMPAR) blocker.
CSN17128 L-701324 142326-59-8 L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
CSN17277 CZC-25146 1191911-26-8 CZC-25146 is a potent LRRK2 inhibitor with IC50 values of 4.76 and 6.87 nM for for wild-type and G2019S mutant LRRK2, respectively. It also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2.
CSN17353 Ro 25-6981 169274-78-6 Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
CSN16970 Mibampator 375345-95-2 LY451395 is a potent and highly selective potentiator of the AMPA receptors.
CSN17354 Eptapirone 179756-58-2 F 11440 is a potent, selective and high efficacy 5-HT1A receptor agonist with pKi value of 8.33.
CSN17279 HG-10-102-01 1351758-81-0 HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 (IC50=23.3 nM) and the G2019S mutant (IC50=3.2 nM)
CSN17179 VU 0364439 1246086-78-1 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
CSN17346 PEAQX 459836-30-7 PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM).
CSN17301 SYM2206 173952-44-8 SYM2206 is a potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM).
CSN17352 Pitolisant 362665-56-3 Pitolisant is a potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).
CSN17035 Lumateperone tosylate 1187020-80-9 Lumateperone tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM).
CSN17362 Firategrast 402567-16-2 Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).
CSN17181 GNE-7915 1351761-44-8 GNE-7915 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 value of 9 nM.
CSN17283 SB-222200 174635-69-9 SB-222200 is a selective, reversible and competitive antagonist of human NK-3 receptor (Ki=4.4 nM) that effectively crosses the blood-brain barrier.
CSN17023 Almorexant 871224-64-5 Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
CSN17315 XEN907 912656-34-9 XEN907 is a spirooxindole NaV1.7 blocker, inhibits hNaV1.7 with IC50 of 3 nM.
CSN17062 CFM-2 178616-26-7 CFM-2 is a selective non-competitive AMPAR antagonist.
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