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NK Receptor

NK Receptor

货号 产品名 CAS号 信息
CSN21667 [bAla8]-Neurokinin A(4-10) 122063-01-8 [bAla8]-Neurokinin A(4-10) is an agonist of NK2 receptor agonist (pD2 = 6.91) that can produce bladder contraction and bronchospasm in guinea pigs.
CSN26517 Vofopitant 168266-90-8 Vofopitant (also known as GR-205,171) is an NK1 receptor antagonist. It has antiemetic effects as with other NK1 antagonists, and also shows anxiolytic actions in animals. It was trialled for applications such as the treatment of social phobia and post-traumatic stress disorder, but did not prove sufficiently effective to be marketed.
CSN12188 Vapreotide 103222-11-3 Vapreotide, a synthetic analog of somatostatin, has NK1R antagonist activity.
CSN19815 Tradipitant 622370-35-8 Tradipitant is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models.
CSN13678 Talnetant 174636-32-9 Talnetant is a potent and selective NK3 receptor antagonist (ki=1.4 nM, hNK-3-CHO), and is 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 μM.
CSN18094 Talnetant HCl 204519-66-4 Talnetant HCl is a potent and selective NK3 receptor antagonist (ki=1.4 nM, hNK-3-CHO), 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 μM.
CSN26711 Substance P TFA 148470-19-3 Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].
CSN22504 Serlopitant 860642-69-9 Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
CSN26343 Senktide 106128-89-6 Senktide is a tachykinin NK3 receptor agonist.
CSN17283 SB-222200 174635-69-9 SB-222200 is a selective, reversible and competitive antagonist of human NK-3 receptor (Ki=4.4 nM) that effectively crosses the blood-brain barrier.
CSN22503 Saredutant 142001-63-6 Saredutant is a selective NK2 receptor antagonist.
CSN19715 Rolapitant 552292-08-7 Rolapitant inhibits CYP2D6, breast cancer resistance protein (BCRP), and Neurokinin (NK)1 Receptor.
CSN16098 (5S,8S)-8-(((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride hydrate 914462-92-3 Rolapitant HCl H2O is a long-acting, selective and competitive NK-1 receptor antagonist.
CSN18026 NKP608 177707-12-9 NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro (IC50=2.6 nM) and in vivo.
CSN26342 Neurokinin A 86933-74-6 Neurokinin A is a peptide agonist of the neurokinin-2 (NK2) receptor.
CSN16120 Netupitant 290297-26-6 Netupitant a potent and highly selective NK1 receptor antagonist with Ki of 0.95 nM.
CSN19286 Pavinetant 941690-55-7 MLE4901 is an antagonist of Neurokinin 3 Receptor and a potential drug for Polycystic ovary syndrome and menopausal hot flushes.
CSN22464 Ibodutant 522664-63-7 MEN 15596 is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1.
CSN21668 Men 10376 135306-85-3 Men 10376 is a selective antagonist of tachykinin NK-2 receptor with Ki of 4.4 μM (rat).
CSN17887 Maropitant 147116-67-4 Maropitant is a neurokinin (NK1) receptor antagonist.
CSN25315 L-732138 148451-96-1 L-732138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist with IC50 of 2.3 nM.
CSN26367 GR-73632 133156-06-6 GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].
CSN18008 Fosaprepitant 172673-20-0 Fosaprepitant is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
CSN12336 Fosaprepitant Dimeglumine 265121-04-8 Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.
CSN32902 Fezolinetant 1629229-37-3 Fezolinetant is Neurokinin-3 (NK-3) receptor antagonist.
CSN26553 Casopitant mesylate 414910-30-8 Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.
CSN10324 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 170729-80-3 Aprepitant is a selective and high-affinity neurokinin-1 receptor antagonist with IC50 of 0.1 nM.
CSN40787 Substance P(1-7) 68060-49-1
CSN40145 Substance P 33507-63-0
CSN33661 Substance P Receptor Antagonist 1 225526-17-0
CSN106765 (S)-N-((S)-6-Amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-1-oxohexan-2-yl)-1-((S)-2-amino-5-guanidinopentanoyl)pyrrolidine-2-carboxamide 69355-89-1
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