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NLR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN33194 | Dapansutrile | 54863-37-5 | OLT1177, a β-sulfonyl nitrile molecule, is a selective inhibitor of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases. |
| CSN18850 | NOD-IN-1 | 132819-92-2 | NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively. |
| CSN16516 | Nodinitib-1 | 799264-47-4 | ML130 is a selective and potent NOD1 inhibitor with IC50 of 560 nM. It inhibits NOD1-induced NF-κB activation. |
| CSN18163 | MCC950 sodium | 256373-96-3 | MCC950 Sodium is a potent and highly specific small molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 nM in BMDMs. |
| CSN18104 | MCC950 | 210826-40-7 | MCC950 is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs. |
| CSN22257 | INF39 | 866028-26-4 | INF39 is an irreversible NLRP3 inhibitor with IC50 value of ~100 μM for inhibiton of NLRP3 ATPase, which can inhibit IL-1β release, caspase activation and pyroptosis in THP-1 cells. |
| CSN27580 | GSK717 | 1595278-21-9 | GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells . |
| CSN21903 | NLRP3-IN-2 | 16673-34-0 | Glibenclamide impurity A is an inhibitor of the formation of the NLRP3 inflammasome in cardiomyocytes. |
| CSN21218 | CY-09 | 1073612-91-5 | CY-09 can inhibit NLRP3 with Kd value of 500 nM through directly bounding to the ATP-binding site of the NLRP3 NACHT domain. |
| CSN25202 | Cardamonin | 18956-16-6 | Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway . |
| CSN33192 | 1-Ethyl-5-methyl-2-phenyl-1H-benzo[d]imidazole | 960119-75-9 | |
| CSN33191 | JC124 | 1638611-48-9 |
